Clustering Outlier Detection Algorithm

Huangtao,Tan Yanna 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.5

Outlier detection and clustering technologies are an important branch of data mining, such as combining the two technologies can improve the mining significance. In this paper, both clustering and outlier detection can be the starting point, proposed a DBSCAN-LOF algorithm is the core idea is to use k_ neighbors thought, DBSCAN redefine the core of the object, making the only non-core objects LOF The operation, thereby reducing the original LOF algorithm is computing the number of global objects, and makes no DBSCAN algorithm input parameters Eps. Real and simulated data sets by experimental results confirm that the algorithm to improve the operating efficiency and the LOF algorithm DBSCAN clustering effect, and while producing clustering and outlier detection results.

Research on Job-shop Scheduling Algorithm of Single Piece and Small Batch MES

Huangtao,Tan yanna 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.6

MES job shop scheduling problem is the core module, and its essence is a kind of resource constraints, time constraints and process constraints such as combinatorial optimization problems, research and application of job shop scheduling problem for China's manufacturing sector improve management, productivity, and the implementation of advanced manufacturing strategies are important, therefore, job shop scheduling research has theoretical and practical significance. In this paper, the slow evolution of GA algorithm will occur, or premature, and the SA algorithm is introduced to the crossover and mutation, genetic simulated annealing algorithm is proposed - GASA algorithm, mathematical model is given algorithm, the algorithm model, the algorithm process. GA parallel sampling of the time optimization algorithm performance can be improved, and the control of SA binding guidelines to control the convergence of the algorithm to avoid prematurity. The classical scheduling problem FT06, GASA correctness of the algorithm is verified and compared with the traditional GA algorithm is verified GASA efficiency of the algorithm.

Induction of Apoptosis by a Combination of Paclitaxel and Carboplatin in the Presence of Hyperthermia

Huang, Tao,Gong, Wei-Hua,Li, Xiu-Cheng,Zou, Chun-Ping,Jiang, Guang-Jian,Li, Xu-Hui,Feng, Dian-Peng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Purpose: To study enhancing effects of paclitaxel in the thermochemotherapy of osteosarcoma cell lines and related mechanisms. Materials and Methods: Paclitaxel and carboplatin were used alone or jointly on OS732 cell lines in the presence of hyperthermia. Inhibition of proliferation was measured by MTT assay and cellular changes were assessed with inverted phase contrast and fluorescence microscopy. Apoptosis was analyzed with flow cytometry (FCM) and Fas expression by immunocytochemistry. Results: At $43^{\circ}C$, one hour after the application of 10ug/ml paclitaxel and $5{\mu}g/ml$ carboplatin on OS732 cells jointly, the survival rate was 15.8% which was significantly lower than with $10{\mu}g/ml$ paclitaxel (45.8%) and $5{\mu}g/ml$ carboplatin (47.7%) respectively (P<0.01). Moreover, changes of morphology and apoptotic rates indicated that the apoptosis-inducing effect of combined application was also much enhanced, as evident also regarding Fas expression. Conclusion: Paclitaxel is conducive to thermochemotherapy of osteosarcoma cell lines, possibly accomplished by up-regulation of Fas expression with induction of apoptosis.

Efficient Killing Effect of Osteosarcoma Cells by Cinobufacini and Cisplatin in Combination

Huang, Tao,Gong, Wei-Hua,Li, Xiu-Cheng,Zou, Chun-Ping,Jiang, Guang-Jian,Li, Xu-Hui,Qian, Hao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Purpose: To study the killing effects on osteosarcoma cells of cinobufacini and cisplatin in combination and the related mechanisms so as to explore the chemotherapeutic method with integrated traditional Chinese and Western medicines. Methods: Cinobufacini and cisplatin were applied to OS732 cells singly or jointly and survival rates were measured by MTT assay. Changes in cellular shape were observed with inverted phase contrast and fluorescence microscopy and apoptosis rates were analyzed with flow cytometry (FCM). Immunocytochemistry were used to examine the Fas expression of OS732 cells. Results: The combination of cinobufacini and cisplatin had the effect of up-regulating Fas expression and inducing apoptosis. The survival rate of combined application of 100 ${\mu}g/ml$ cinobufacini and 1 ${\mu}g/ml$ cisplatin on OS-732 cells was significantly lower than with either of the agents alone (p<0.01). Changes in cellular shape and apoptotic rates also indicated the apoptosis-inducing effects of combined application were much enhanced. Conclusion: The combination of cinobufacini and cisplatin demonstrated strong killing effects on OS-732 cells which might be related to up-regulation of Fas expression.

Knowledge Map Analysis of Smart Tourism Research: Comparison of Chinese and English Papers

Huang, Tao,Li, Yunpeng Smart Tourism Research Center 2021 Journal of smart tourism Vol.1 No.4

Smart tourism and associated topics have been extensively discussed by scholars around the world. The goal of this study is to make available an all-inclusive database-based analysis of the longitude status of research on smart tourism. Three databases, Web of Science (WoS), Science Direct and China Knowledge Network (CNKI), were utilized to gather papers published from 2011 to 2020. The data results were analyzed and results were generated using CiteSpace. The results of Chinese and English papers were evaluated to form the conclusion of this study. The implication formed the prediction of future research trends and development suggestions.

Oxaliplatin Sensitizes OS Cells to TRAIL-induced Apoptosis Via Down-regulation of Mcl1

Huang, Tao,Gong, Wei-Hua,Li, Xiu-Cheng,Zou, Chun-Ping,Jiang, Guang-Jian,Li, Xu-Hui,Qian, Hao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Purpose: To investigate the killing effect on OS cells of a combination of oxaliplatin and TRAIL and related molecular mechanisms. Methods: TRAIL and oxaliplatin were applied to OS732 cells singly or jointly and survival inhibition rates were measured by MTT assay, changes of cellular shape being assessed with inverted phase contrast and fluorescence microscopy. Apoptotic rates were analyzed by flow cytometry (FCM) and immunocytochemistry was used to examine Mcl1 expression of OS732 cells. Results: The survival inhibition rate of combined application of $100{\mu}g/ml$ TRAIL and $1{\mu}g/ml$ oxaliplatin on OS-732 cells was significantly higher than that of either agent singly (p<0.01). Changes of cellular shape and apoptotic rates also indicated apoptosis-inducing effects of combined application to be much stronger than those of individual application. Oxaliplatin had the effect of down-regulating Mcl1 expression and sensitizing OS cells to TRAIL-induced apoptosis. Conclusion: A combination of TRAIL and oxaliplatin exerts strong killing effects on OS-732 cells which might be related to down-regulation of Mcl1 expression.

Impact test of a centrifugal pump used in nuclear power plant under aircraft crash scenario

Huang, Tao,Chen, Mengmeng,Li, Zhongcheng,Dong, Zhanfa,Zhang, Tiejian,Zhou, Zhiguang Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.6

Resisting an accidental impact of large commercial aircrafts is an important aspect of advanced nuclear power plant (NPP) design. Especially after the 9·11 event, some regulations were enacted, which required the design of NPPs should consider the accidental impact of large commercial aircrafts. Normal working of equipment is important for stopping reactor under an impact when an NPP is in operation. However, there is a lack of reliable analysis and research on the impact test of nuclear prototype equipment. Therefore, in order to study the response of the equipment under high acceleration impact, a centrifugal pump is selected as the research object to perform the impact test. A horizontal half-sinusoidal pulse wave was applied to the working pump. The test results show that the horizontal response of the motor and flange is greater compared to other parts, as well as the vertical response of the coupling. The stress response of the pump body support and motor support is high, hence these parts should be considered in the design of the pump. Finally, combined with the damage and stress evaluation results of the pump under different amplitudes, the ultimate impact acceleration that the pump can withstand is given.