The Meaning of Diversity : American Culture in New Perspective

Horton, Lois E. 한국아메리카학회 1994 美國學論集 Vol.25 No.-

영국의 성별 임금격차 보고

Rachel Horton 한국노동연구원 2019 국제노동브리프 Vol.17 No.1

The Church and Its Mission: Evaluating ‘Faith and Order Paper 198’

Micheal Horton 한국개혁신학회 2011 한국개혁신학 Vol.31 No.-

In Santiago de Compostela, Spain, the WCC’s Fifth World Conference on Faith and Order (1993) strongly urged the drafting of a statement on the nature and mission of the church. The resulting document, Faith and Order Paper 198, is titled, “The Nature and Mission of the Church: A Stage on the Way to a Common Statement.”Of course, the unity of the church lies at the heart of the mission of the Faith and Order Commission—indeed, of the World Council of Churches itself. My paper offers a summary and evaluation of this important document from a confessional Reformed perspective. After summarizing Paper 198, including areas of agreement as well as critique, this paper also engages with approaches to these questions often found in current evangelical discussions of mission. Drawing on distinctively Reformed approaches, the principal argument is that the mission of the church is to execute the marks of the church, which are the same as the keys of the kingdom. There can be no antithesis, therefore, between the church-as-place (defined by its marks of public worship) and the church-as-people (defined by mission). In fact, even the attributes of the church are manifested publicly by these marks. Where the gospel is being preached, the sacraments are being administered, and the officers are caring for the flock, we may be confident that the mission is being executed, the keys are being exercised, and the attributes of “one holy, catholic, and apostolic church” are being exhibited. Preaching, sacrament, and discipline are singled out in the Great Commission and, as we have seen, in Acts 2:42. If these are missing, marginalized, or obscured, there is no office, no charismatic ministry, and no innovative program that can build and expand Christ’s kingdom. God may use many means, but he has ordained these and has promised to work the greatest signs and wonders through them. In this way, the New Jerusalem is seen as an eschatological event—a people united to the Son as his Bride, coming down from heaven. It is not a kingdom that we are building, but one that we are receiving (Heb 12:28). And yet, it is also an enduring city in this passing evil age, a historical institution that, for all of its failures, remains the embassy of grace that Christ is building among the ruins of the City of Man.

Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring

( Anthony Horton ),( Brian Sullivan ),( Katie Charles ),( Thasha Mcintosh ),( Andrea Davis ),( Ziad Gellad ),( Rahul Shimpi ),( C Prakash Gyawali ),( Amit Patel ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.4

Background/Aims Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar between acquisition methods across HRIM manufacturers. We aim to assess correlations between MNBI and BI from HRIM (BI-HRIM) from 2 HRIM manufacturers in the setting of physiologic acid exposure time (AET). Methods HRIM and pH-impedance monitoring demonstrating physiologic AET (< 4%) off proton pump inhibitors were required. BI-HRIM was extracted as the average from 5 cm and 10 cm above the lower esophageal sphincter. Distal BI-HRIM (DBI-HRIM) was also extracted from the most distal channel (Medtronic studies). MNBI was extracted from 6 channels. Concordance between BI-HRIM across manufacturers with MNBI was analyzed. Results Thirty-six patients met the inclusion criteria (59.6 ± 1.7 years; 22% female; body mass index 30.5 ± 0.7; AET 1.6 ± 0.2%). Although MNBI was similar at all channels (P ≥ 0.18), Diversatek BI-HRIM was lower than Medtronic BI-HRIM (P = 0.003). Overall, BI-HRIM correlated with MNBI at corresponding recording sites, 7 cm and 9 cm (P < 0.05), but not at other sites (P ≥ 0.19). Pearson’s correlations > 0.5 were seen at MNBI at 7 cm for both systems, and at 9 cm for Medtronic. DBI-HRIM correlated with MNBI at 3 cm and 5 cm (P < 0.03), but not at other locations (P > 0.1). Conclusions While numeric differences exist between manufacturers, BI-HRIM correlates with MNBI from corresponding channels in patients with physiologic AET. Comparison with AET elevation is needed to determine correlations between pathologic MNBI with BI-HRIM across manufacturers. The optimal HRIM channels from which BI values should be extracted also warrants further study. (J Neurogastroenterol Motil 2020;26:455-462)

The Church and Its Mission: Evaluating "Faith and Order Paper 198"

( Michael S. Horton ) 한국개혁신학회 2011 한국개혁신학 Vol.31 No.-

In Santiago de Compostela, Spain, the WCC`s Fifth World Conference on Faith and Order (1993) strongly urged the drafting of a statement on the nature and mission of the church. The resulting document, Faith and Order Paper 198, is titled, "The Nature and Mission of the Church: A Stage on the Way to a Common Statement." Of course, the unity of the church lies at the heart of the mission of the Faith and Order Commission-indeed, of the World Council of Churches itself. My paper offers a summary and evaluation of this important document from a confessional Reformed perspective. After summarizing Paper 198, including areas of agreement as well as critique, this paper also engages with approaches to these questions often found in current evangelical discussions of mission. Drawing on distinctively Reformed approaches, the principal argument is that the mission of the church is to execute the marks of the church, which are the same as the keys of the kingdom. There can be no antithesis, therefore, between the church-as-place (defined by its marks of public worship) and the church-as-people (defined by mission). In fact, even the attributes of the church are manifested publicly by these marks. Where the gospel is being preached, the sacraments are being administered, and the officers are caring for the flock, we may be confident that the mission is being executed, the keys are being exercised, and the attributes of "one holy, catholic, and apostolic church" are being exhibited. Preaching, sacrament, and discipline are singled out in the Great Commission and, as we have seen, in Acts 2:42. If these are missing, marginalized, or obscured, there is no office, no charismatic ministry, and no innovative program that can build and expand Christ`s kingdom. God may use many means, but he has ordained these and has promised to work the greatest signs and wonders through them. In this way, the New Jerusalem is seen as an eschatological event-a people united to the Son as his Bride, coming down from heaven. It is not a kingdom that we are building, but one that we are receiving (Heb 12:28). And yet, it is also an enduring city in this passing evil age, a historical institution that, for all of its failures, remains the embassy of grace that Christ is building among the ruins of the City of Man.

Value of Ultrasound in Rheumatologic Diseases

강태영,Laura Horton,Paul Emery,Richard J. Wakefield 대한의학회 2013 Journal of Korean medical science Vol.28 No.4

The use of musculoskeletal ultrasound in rheumatology clinical practice has rapidly increased over the past decade. Ultrasound has enabled rheumatologists to diagnose,prognosticate and monitor disease outcome. Although international standardization remains a concern still, the use of ultrasound in rheumatology is expected to grow further as costs fall and the opportunity to train in the technique improves. We present a review of value of ultrasound, focusing on major applications of ultrasound in rheumatologic diseases.

Effects of Method and Time of Castration on Growth and Carcass Characteristics of Omani Sheep

Mahgoub, O.,Horton, G.M.J.,Olvey, F.H. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.2

Thirty two Omani sheep with eight animals each of; intact males (INT), males castrated with rubber rings immediately after birth (RR), males castrated with a burdizzo at 8 weeks of age (BC) and intact females (IF) were fed ad libitum a concentrate diet (CP 16%) plus chopped Rhodesgrass hay (8% CP) from weaning until slaughter at 28 kg. INT lambs grew faster from 9 to 20 weeks of age (p < 0.05) thus they were significantly heavier at 20 weeks of age than BC and IF, but not RR lambs. INT consumed more total feed than other sex groups over the period from 9 to 20 weeks of age. There were no significant differences between lambs of all experimental groups in feed per gain ratio. INT lambs had lower (p < 0.01) dressing percentage (DP) than RR, BC and IF. As a percentage in the empty body weight (EBW), INT had higher proportions of head, feet, empty gut (p < 0.001), liver (p < 0.05) and genitals (p < 0.05) but lower proportions of lungs and trachea (p < 0.05) than BC and IF lambs. INT males had a significantly higher (p < 0.05) proportion of bone than RR and IF lambs but lower (p < 0.05) proportion of fat than RR and IF. As a percentage in EBW, IF had the highest protortion (p < 0.001) of total body fat (TBF) followed by BC and RR whereas INT males had the lowest proportion. There was a general trend of IF having the highest proportion of individual and total non-carcass fat (TNCF) and total carcass fat (TCF) followed by BC and RR lambs whereas INT lambs had the lowest protortions of individual carcass and non-carcass fat depots. There were only few sex or castration effects on carcass tissue distribution. IF had higher proportions of intermuscular fat in the chuck, plate, leg and flank than INT and BC. The current study demonstrated that castration of intensively-raised male Omani native sheep especially at weaning using a burdizzo retarded growth rate and reduced carcass quality by increasing fat content.

The impact of endotrophin on the progression of chronic liver disease

김민,이창헌,서대윤,이효정,Horton Jay D.,박지영,Scherer Philipp E. 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and can lead to multiple complications, including non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. The fibrotic liver is characterized by the pathological accumulation of extracellular matrix (ECM) proteins. Type VI collagen alpha3 (Col6a3) is a biomarker of hepatic fibrosis, and its cleaved form, endotrophin (ETP), plays a critical role in adipose tissue dysfunction, insulin resistance, and breast cancer development. Here, we studied the effects of the Col6a3-derived peptide ETP on the progression of chronic liver diseases, such as NASH and liver cancer. We used a doxycycline (Dox)-inducible liver-specific ETP-overexpressing mouse model on a NAFLD-prone (liver-specific SREBP1a transgenic) background. For this, we evaluated the consequences of local ETP expression in the liver and its effect on hepatic inflammation, fibrosis, and insulin resistance. Accumulation of ETP in the liver induced hepatic inflammation and the development of fibrosis with associated insulin resistance. Surprisingly, ETP overexpression also led to the emergence of liver cancer within 10 months in the SREBP1a transgenic background. Our data revealed that ETP can act as a “second hit” during the progression of NAFLD and can play an important role in the development of NASH and hepatocellular carcinoma (HCC). These observations firmly link elevated levels of ETP to chronic liver disease.

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function

Tai, Yu-Tzu,Horton, Holly M.,Kong, Sun-Young,Pong, Erik,Chen, Hsing,Cemerski, Saso,Bernett, Matthew J.,Nguyen, Duc-Hanh T.,Karki, Sher,Chu, Seung Y.,Lazar, Greg A.,Munshi, Nikhil C.,Desjarlais, John R American Society of Hematology 2012 Blood Vol.119 No.9

<B>Abstract</B><P>HM1.24, an immunologic target for multiple myeloma (MM) cells, has not been effectively targeted with therapeutic monoclonal antibodies (mAbs). In this study, we investigated in vitro and in vivo anti-MM activities of XmAb5592, a humanized anti-HM1.24 mAb with Fc-domain engineered to significantly enhance FcγR binding and associated immune effector functions. XmAb5592 increased antibody-dependent cellular cytotoxicity (ADCC) several fold relative to the anti-HM1.24 IgG1 analog against both MM cell lines and primary patient myeloma cells. XmAb5592 also augmented antibody dependent cellular phagocytosis (ADCP) by macrophages. Natural killer (NK) cells became more activated by XmAb5592 than the IgG1 analog, evidenced by increased cell surface expression of granzyme B-dependent CD107a and MM cell lysis, even in the presence of bone marrow stromal cells. XmAb5592 potently inhibited tumor growth in mice bearing human MM xenografts via FcγR-dependent mechanisms, and was significantly more effective than the IgG1 analog. Lenalidomide synergistically enhanced in vitro ADCC against MM cells and in vivo tumor inhibition induced by XmAb5592. A single dose of 20 mg/kg XmAb5592 effectively depleted both blood and bone marrow plasma cells in cynomolgus monkeys. These results support clinical development of XmAb5592, both as a monotherapy and in combination with lenalidomide, to improve patient outcome of MM.</P>

Non-photochemical quenching of chlorophyll fluorescence in the green alga Dunaliella

Lee, C. B.,Rees, D.,Horton, P. 동의대학교 기초과학연구소 1991 基礎科學硏究論文集 Vol.1 No.1

The relaxation of the non-photochemical quenching of chlorophyll fluorescence has been investigated in cells of the green alga Dunaliella following illumination. The relaxation after the addition of DCMU or darkening was strongly biphasic. The uncoupler NH₄Cl induced rapid relaxation of both phases, which were therefore both energy-dependent quenching, qE. The proportion of the slow phase of qE increased at increasing light intensity. In the presence of the inhibitors rotenone and antimycin the slow phase of qE was stabilised for in excess of 15 min. NaN₃inhibited the relaxation of almost all the qE. The implications of these results are discussed in terms of the interpretation of the non-photochemical quenching of chlorophyll fluorescence in vivo and the mechanism of qE.