http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hon Keung Tony Ng (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
김진흠,Hon Keung Tony Ng,김성욱 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.6
Purpose: In clinical studies, patients may experience several types of events during follow up under the competing risks (CR)framework. Patients are often classified into low- and high-risk groups based on prognostic factors. We propose a method to determinean optimal cutpoint value for prognostic factors on censored outcomes in the presence of CR. Materials and Methods: We applied our method to data collected in a study of lung cancer patients. From September 1, 1991 toDecember 31, 2005, 758 lung cancer patients received tumor removal surgery at Samsung Medical Center in Korea. The proposedstatistic converges in distribution to that of the supremum of a standardized Brownian bridge. To overcome the conservativeness ofthe test based on an approximation of the asymptotic distribution, we also propose a permutation test based on permuted samples. Results: Most cases considered in our simulation studies showed that the permutation-based test satisfied a significance level of0.05, while the approximation-based test was very conservative: the powers of the former were larger than those of the latter. Theoptimal cutpoint value for tumor size (unit: cm) prior to surgery for classifying patients into two groups (low and high risks for relapse)was found to be 1.8, with decent significance reflected as p values less than 0.001. Conclusion: The cutpoint estimator based on the maximally selected linear rank statistic was reasonable in terms of bias and standarddeviation in the CR framework. The permutation-based test well satisfied type I error probability and provided higher powerthan the approximation-based test.
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
