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Hojjat-Allah Abbaszadeh,Somayeh Niknazar,Shahram Darabi,Navid Ahmady Roozbahany,Ali Noori-Zadeh,Seyed Kamran Ghoreishi,Maryam Sadat Khoramgah,Yousef Sadeghi 대한해부학회 2018 Anatomy & Cell Biology Vol.51 No.3
Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.
Ehsan-o-llah Ettefaghi,Hojjat Ahmadi,Seyed Saeid Mohtasebi,Alimorad Rashidi 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
This study investigated anti-wear properties of SAE-20W50 engine oil, containing fullerene spherical nanoparticles, carbon nano balls and vanadium oxide nanotubes. Three kinds of wear tests including four-ball test, pin on disc test and engine tribo-test were done on base oil and nano lubricants, which were made at 0.1%wt concentration. The results obtained from four-ball standard tests indicated 5-15% reduction in rate of wear in nano lubricants. In addition, the results of pin on disc and engine tests on sliding bearings showed that the amount of wear and surface quality of bearings in nano lubricants with respect to the base oil considerably improved.
Zahra Azimzadeh,Samareh Omidvari,Somayeh Niknazar,Saeed Vafaei-Nezhad,Navid Ahmady Roozbahany,Mohammad-Amin Abdollahifar,Foozhan Tahmasebinia,Gholam-Reza Mahmoudiasl,Hojjat Allah Abbaszadeh,Shahram Da 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1
Methamphetamine (METH) can potentially disrupt neurotransmitters activities in the central nervous system (CNS) and cause neurotoxicity through various pathways. These pathways include increased production of reactive nitrogen and oxygen species, hypothermia, and induction of mitochondrial apoptosis. In this study, we investigated the long-term effects of METH addiction on the structural changes in the amygdala of postmortem human brains and the involvement of the brain- cAMP response element-binding protein/brain-derived neurotrophic factor (CREB/BDNF) and Akt-1/GSK3 signaling pathways. We examined ten male postmortem brains, comparing control subjects with chronic METH users, using immunohistochemistry, real-time polymerase chain reaction (to measure levels of CREB, BDNF, Akt-1, GSK3, and tumor necrosis factor-α [TNF-α]), Tunnel assay, stereology, and assays for reactive oxygen species (ROS), glutathione disulfide (GSSG), and glutathione peroxidase (GPX). The findings revealed that METH significantly reduced the expression of BDNF, CREB, Akt-1, and GPX while increasing the levels of GSSG, ROS, RIPK3, GSK3, and TNF-α. Furthermore, METH-induced inflammation and neurodegeneration in the amygdala, with ROS production mediated by the CREB/BDNF and Akt-1/GSK3 signaling pathways.