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Kibria, Golam,Hatakeyama, Hiroto,Harashima, Hideyoshi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Multidrug resistance (MDR), the principal mechanism by which many cancers develop resistance to chemotherapy, is one of the major obstacles to the successful clinical treatment of various types of cancer. Several key regulators are responsible for mediating MDR, a process that renders chemotherapeutic drugs ineffective in the internal organelles of target cells. A nanoparticulate drug delivery system (DDS) is a potentially promising tool for circumventing such MDR, which can be achieved by targeting tumor cells themselves or tumor endothelial cells that support the survival of MDR cancer cells. The present article discusses key factors that are responsible for MDR in cancer cells, with a specific focus on the application of DDS to overcome MDR via the use of chemotherapy or macromolecules.
Golam Kibria,Hiroto Hatakeyama,Hideyoshi Harashima 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Multidrug resistance (MDR), the principalmechanism by which many cancers develop resistance tochemotherapy, is one of the major obstacles to the successfulclinical treatment of various types of cancer. Severalkey regulators are responsible for mediating MDR, aprocess that renders chemotherapeutic drugs ineffective inthe internal organelles of target cells. A nanoparticulatedrug delivery system (DDS) is a potentially promising toolfor circumventing such MDR, which can be achieved bytargeting tumor cells themselves or tumor endothelial cellsthat support the survival of MDR cancer cells. The presentarticle discusses key factors that are responsible for MDRin cancer cells, with a specific focus on the application ofDDS to overcome MDR via the use of chemotherapy ormacromolecules.