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A Bioactive Depsidone from Lachnum virgineum (Hyaloscyphaceae)
Yoshihito Shiono,Takuya Koseki,Hiromasa Koyama 한국생약학회 2018 Natural Product Sciences Vol.24 No.2
Norcolensoic acid (1) was isolated from both the fruiting bodies and the liquid culture of Lachnum virgineum. The structures of 1 was determined using spectroscopic methods. Compound 1 was isolated for the first time from this fungus. Compound 1 showed moderate antibacterial and phytotoxic activities.
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Primary Adenocarcinoma of the Minor Duodenal Papilla
Takeru Wakatsuki,Atsushi Irisawa,Tadayuki Takagi,Yoshihisa Koyama,Sayuri Hoshi,Seiichi Takenoshita,Masafumi Abe,Hiromasa Ohira 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.2
A 70-year-old man was admitted to our institution due to aggravation of blood-sugar level control and because an abdominal CT showed dilatation of the main pancreatic duct. Upper gastrointestinal endoscopy revealed a flat elevated tumor with central ulceration in the second portion of the duodenum. Subsequent duodenoscopy for a more detailed examination showed that the tumor had originated in the minor duodenal papilla. A biopsy specimen showed moderately differentiated adenocarcinoma. Endoscopic retrograde pancreatography via the major duodenal papilla revealed a slightly dilated main pancreatic duct and obstruction of the accessory pancreatic duct. Endoscopic ultrasonography showed a hypoechoic mass in the minor duodenal papilla with retention of the muscularis propria of the duodenum. These findings suggest that the tumor existed only to a limited extent in the minor duodenal papilla, and that the tumor did not infiltrate into the pancreas. For treatment, pylorus-preserving pancreatoduodenectomy was performed, and histological findings revealed a well- differentiated adenocarcinoma that originated in the minor duodenal papilla. Primary adenocarcinoma of the minor duodenal papilla is extremely rare. Our case is the first report of primary adenocarcinoma of the minor duodenal papilla at an early stage with no infiltration into muscularis propria of the duodenum and pancreas.
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