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Frequency Analysis of intracellular signal transduction systems
Hiroki Ishiyama,Takashi Nakakuki,Chiharu Ishii,Mitsuo Kobayashi 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
In this paper, we propose two analysis methods for a complicated and huge biological system. As a practical biological system, we employ a newly published signal transduction system with transcriptional control. For such a system, only few analysis tools such as parameter sensitivity analysis are available. First, we extend the concept of Bode diagram, including the effect of changes of both amplitude are frequency of input signal on output response. Next, we introduce the calculation of the L2-induced gain. Although it is difficult to find the nominal gain theoretically, we show that the distribution of the gain over various amplitudes and frequencies of input signal provides us some useful information in a biological system.