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Herrero, Maria-Luz,Brurberg, May Bente,Ojeda, Dario I.,Roleda, Michael Y. The Korean Society of Phycology 2020 ALGAE Vol.35 No.1
Pythium species are ubiquitous organisms known to be pathogens to terrestrial plants and marine algae. While several Pythium species (hereafter, Pythium) are described as pathogens to marine red algae, little is known about the pathogenicity of Pythium on marine green algae. A strain of a Pythium was isolated from a taxonomically unresolved filamentous Ulva collected in an intertidal area of Oslo fjord. Its pathogenicity to a euryhaline Ulva intestinalis collected in the same area was subsequently tested under salinities of 0, 15, and 30 parts per thousand (ppt). The Pythium isolate readily infected U. intestinalis and decimated the filaments at 0 ppt. Mycelium survived on U. intestinalis filaments for at least 2 weeks at 15 and 30 ppt, but the infection did not progress. Sporulation was not observed in the infected algal filaments at any salinity. Conversely, Pythium sporulated on infected grass pieces at 0, 15, and 30 ppt. High salinity retarded sporulation, but did not prevent it. Our Pythium isolate produced filamentous non-inflated sporangia. The sexual stage was never observed and phylogenetic analysis using internal transcribed spacer suggest this isolate belongs to the clade B2. We conclude that the Pythium found in the Oslo fjord was a pathogen of U. intestinalis under low salinity.
Guaranteed Set-point Computation with Application to the Control of a Sailboat
Pau Herrero,Luc Jaulin,Josep Vehí,Miguel A. Sainz 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.1
The problem of characterizing in a guaranteed way the set of all feasible set-points of a control problem is known to be difficult. In the present work, the problem to be solved involves non-linear equality constraints with variables affected by logical quantifiers. This problem is not solvable by cur-rent symbolic methods like quantifier elimination, which is commonly used for solving this class of problems. We propose the utilization of guaranteed set-computation techniques based on interval analysis, in particular a solver referred to as Quantified Set Inversion (QSI). As an application example, the problem of simultaneously controlling the speed and the orientation of a sailboat is presented. For this purpose, the combination of QSI solver and feedback linearization techniques is employed.
Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
( Alba Herrero ),( Aitor Benedicto ),( Irene Romayor ),( Elvira Olaso ),( Beatriz Arteta ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.3
Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE2 secretion. To elucidate the role of the LSEC intercellular adhesion molecule-1 (ICAM-1) in the prometastatic response exerted by tumor and stromal COX-2, we utilized celecoxib (CLX) as a COX-2 inhibitory agent. We analyzed the in vitro proliferative and secretory responses of murine C26 colorectal cancer (CRC) cells to soluble ICAM-1 (sICAM-1), cultured alone or with LSECs, and their effect on LSEC and hepatic stellate cell (HSC) migration and in vivo liver metastasis. CLX reduced sICAM-1-stimulated COX-2 activation and PGE2 secretion in C26 cells cultured alone or cocultured with LSECs. Moreover, CLX abrogated sICAM-1-induced C26 cell proliferation and C26 secretion of promigratory factors for LSECs and HSCs. Interestingly, CLX reduced the protumoral response of HSC, reducing their migratory potential when stimulated with C26 secretomes and impairing their secretion of chemotactic factors for LSECs and C26 cells and proliferative factors for C26 cells. In vivo, CLX abrogated the prometastatic ability of sICAM-1-activated C26 cells while reducing liver metastasis. COX-2 inhibition blocked the creation of a favorable tumor microenvironment (TME) by hindering the intratumoral recruitment of activated HSCs and macrophages in addition to the accumulation of fibrillar collagen. These results point to COX-2 being a key modulator of processes initiated by host ICAM-1 during tumor cell/LSEC/HSC crosstalk, leading to the creation of a prometastatic TME in the liver.
Do platelet concentrates accelerate orthodontic tooth movement?: a systematic review
Sergio Herrero-Llorente,Angel-Orión Salgado-Peralvo,Jan G.J.H. Schols 대한치주과학회 2023 Journal of Periodontal & Implant Science Vol.53 No.1
Purpose: Surgical techniques in orthodontics have received widespread attention in recent years. Meanwhile, biomaterials with high molecular content have been introduced, such as platelet concentrates (PCs), which may accelerate orthodontic tooth movement (OTM) and reduce periodontal damage. The present systematic review aimed to answer the following PICO question: “In patients in whom orthodontic surgical techniques are performed (P), what is the effectiveness of using PCs over the surgical site (I) when compared to not placing PCs (C) to achieve faster tooth movement (O)?” Methods: A search was performed in 6 databases. The criteria employed were those described in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses declaration. The present review included studies with a control group that provided information about the influence of PCs on the rate of OTM. Results: The electronic search identified 10 studies that met the established criteria. Conclusions: The included studies were very diverse, making it difficult to draw convincing conclusions. However, a tendency was observed for OTM to be accelerated when PCs were used as an adjuvant for canine distalization after premolar extraction when distalization was started in the same session. Likewise, studies seem to indicate an association between PC injection and the amount of canine retraction. However, it is not possible to affirm that the use of PCs in corticotomy shortens the overall treatment time, as this question has not been studied adequately.
An Approach to Art Collections Management and Content-based Recovery
De Celis Herrero, Concepcion Perez,Alvarez, Jaime Lara,Aguilar, Gustavo Cossio,Garcia, Maria Josefa Somodevilla Korea Information Processing Society 2011 Journal of information processing systems Vol.7 No.3
This study presents a comprehensive solution to the collection management, which is based on the model for Cultural Objects (CCO). The developed system manages and spreads the collections that are safeguarded in museums and galleries more easily by using IT. In particular, we present our approach for a non-structured search and recovery of the objects based on the annotation of artwork images. In this methodology, we have introduced a faceted search used as a framework for multi-classification and for exploring/browsing complex information bases in a guided, yet unconstrained way, through a visual interface.
Vaccarella, S.,Herrero, R.,Snijders, P. J F,Dai, M.,Thomas, J. O,Hieu, N. T.,Ferreccio, C.,Matos, E.,Posso, H.,de Sanjose, S.,Shin, H. R.,Sukvirach, S.,Lazcano-Ponce, E.,Munoz, N.,Meijer, C. J L M,Fra Oxford University Press 2008 International journal of epidemiology Vol.37 No.3
<P>BACKGROUND: Smoking increases the risk of squamous-cell carcinoma of the cervix, but it is not clear whether smoking increases the risk of acquisition or persistence of human papillomavirus (HPV) infection. METHODS: Information on smoking was collected from 10 areas in four continents among population-based, age-stratified random samples of women aged 15 years or older. HPV testing was performed using PCR-based enzyme immunoassay. Unconditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) of being HPV-positive by smoking habits, adjusted for age and lifetime number of sexual partners. RESULTS: Ten thousand five hundred and seventy-seven women (mean age 41.4 years) were included. Among current smokers, the risk of being HPV-positive increased with smoking intensity, after allowing for lifetime number of sexual partners: ORs for <5, 5-14 and >/=15 cigarettes per day were 1.21 (95% CI 0.95-1.54), 1.39 (95% CI 1.04-1.87) and 2.01 (95% CI 1.32-3.08), respectively, as compared with never-smokers. The risk among former smokers (OR = 0.95, 95% CI 0.73-1.23) was similar to that among never-smokers. Analyses stratified by lifetime number of sexual partners showed a significant trend in risk only for women with one lifetime sexual partner. CONCLUSIONS: Our study suggests that current, though not former, smoking is associated with an increased prevalence of HPV, after allowance for sexual covariates. Among current smokers, HPV prevalence increased with smoking intensity, but a clear dose-response relationship was exclusively seen among women who declared one lifetime sexual partner.</P>
On the Performance of Oracle Grid Engine Queuing System for Computing Intensive Applications
Kolici, Vladi,Herrero, Albert,Xhafa, Fatos Korea Information Processing Society 2014 Journal of information processing systems Vol.10 No.4
In this paper we present some research results on computing intensive applications using modern high performance architectures and from the perspective of high computational needs. Computing intensive applications are an important family of applications in distributed computing domain. They have been object of study using different distributed computing paradigms and infrastructures. Such applications distinguish for their demanding needs for CPU computing, independently of the amount of data associated with the problem instance. Among computing intensive applications, there are applications based on simulations, aiming to maximize system resources for processing large computations for simulation. In this research work, we consider an application that simulates scheduling and resource allocation in a Grid computing system using Genetic Algorithms. In such application, a rather large number of simulations is needed to extract meaningful statistical results about the behavior of the simulation results. We study the performance of Oracle Grid Engine for such application running in a Cluster of high computing capacities. Several scenarios were generated to measure the response time and queuing time under different workloads and number of nodes in the cluster.
Comparative Study of the Dissolution Profiles of a Commercial Theophylline Product after Storage
Negro, S.,Herrero-Vanrell, R.,Barcia, E.,Villegas, S. The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.6
The purpose of this work was to study the effect of storage time and temperature on the in vitro release kinetics of a commercial sustained-release dosage form of theophylline, at different pHs of the dissolution medium. The formulation was stored at $35^{\circ}C$ for 16 months and at $45^{\circ}C$ for 8 months, with a relative humidity of 60%. The in vitro release tests were performed at pHs 2, 4, 6 and 7.4. The mean values of the transport coefficient n, were close to 0.5 in all the conditions tested, which indicates that the transport system is not modified after storage of the formulation at $35^{\circ}C$ and $45^{\circ}C$. The mean values of the dissolution rate constant ranged from 0.036 to 0.043 $min^{-n}$, under all the conditions tested. Significant differences (${\alpha}=0.05$) were found between pHs 2, 4 and 6, 7.4 for all the model-independent parameters studied. When the formulation was kept at $35^{\circ}C$ for 16 months, the mean percentage of drug dissolved at 8 hours was 25.61% (pHs 2, 4) and, 36.12% (pHs 6, 7.4), representing a 26% and 24% reduction, respectively. Simitar results were obtained after storing the formulation at $45^{\circ}C$ for 8 months, corresponding to 33.3% (pHs 2, 4) and, 22.5% (pHs 6, 7.4) diminution, respectively. The values of the similarity factory $f_2$, obtained were lower than 50, which indicates the lack of similarity among the dissolution profiles, after storing the formulation under the experimental Conditions tested.
Surface phase transitions in BiFeO3below room temperature
Jarrier, R.,Marti, X.,Herrero-Albillos, J.,Ferrer, P.,Haumont, R.,Gemeiner, P.,Geneste, G.,Berthet, P.,Schü,lli, T.,Cevc, P.,Blinc, R.,Wong, Stanislaus S.,Park, Tae-Jin,Alexe, M.,Carpenter, M. A. American Physical Society 2012 Physical review. B, Condensed matter and materials Vol.85 No.18