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Xiao, Wei-Lie,Shen, Yun-Heng,Niu, Xue-Mei,Sun, Han-Dong,Li, Sheng-Hong 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two new coumarin glucosides, $11-O-{\beta}-D-glucopyranosyl$ thamnosmonin (1) and $12-O-{\beta}-D-glucopyranosyl$ gosferol (2), were isolated from the roots of Angelica apaensis. Their structures were elucidated spectroscopically. Both compounds showed weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA and APD.
Qin Tang,Xiaoping Lin,Shengshi Zhao,Yi Niu,Heng Sun,Yun Dong 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.4
Columnar-structured Mg97.27Zn2.54Y0.19alloy with the preferred growth direction of ⟨22̄45⟩ and ⟨12̄33⟩, andMg98.01Zn1.84Y0.13Zr0.03alloy with the preferred growth direction of ⟨11̄20⟩ were prepared using the directional solidificationtechnique and then tensile tested at 250–300 °C. The results showed that the Mg97.27Zn2.54Y0.19alloy with columnar dendriticstructure experienced a significant deformation strengthening period when stretched at 250 °C, and a typical dynamicrecrystallization stage at 300 °C, which were mainly accounted for its well-developed secondary dendrites, a large numberof branch-shaped second phases distributed in the longitudinal grain boundary, and less granular second phases existingin the crystal. While in the whole test temperature range (250–300 °C), the stress–strain curves of Mg98.01Zn1.84Y0.13Zr0.03alloys with cellular dendritic crystals showed a steady deformation state because of the second phases with strip distributingin the longitudinal grain boundary, which was induced by a balance between the deformation strengthening and the dynamicrecrystallization. Especially at 300 °C, this steady deformation state existed in the strain of 5.6%–36%. The good uniformplastic deformation was closely related to the small misorientations between columnar grains, the associated movement ofgrains by grain boundary slipping, and the less percentage of dynamically recrystallized grains which could do harm to theorientation continuity of the columnar crystals.
Wei-Lie Xiao,Sheng-Hong Li,Yun-Heng Shen,Xue-Mei Niu,Han-Dong Sun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two new coumarin glucosides, 11-O-β-D-glucopyranosyl thamnosmonin (1) and 12-O-β-D-glucopyranosyl gosferol (2), were isolated from the roots of Angelica apaensis. Their structures were elucidated spectroscopically. Both compounds showed weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA and APD.
Wenzhu Dai,Jixiang He,Ling Zheng,Mingyu Bi,Fei Hu,Minju Chen,Heng Niu,Jingyu Yang,Ying Luo,Wenru Tang,Miaomiao Sheng 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Breast cancer is the most frequently diagnosed malignancy in women worldwide. MicroRNAs (miRNAs) are thought to serve as potential biomarkers in various cancers, including breast cancer. Methods: We evaluated the miRNA expression profiles in 1,083 breast cancer samples and 104 normal breast tissues from The Cancer Genome Atlas database. We used the edgeR package of R software to analyze the differentially expressed miRNAs in normal and cancer tissues, and screened survival-related miRNAs by Kaplan-Meier analysis. A receiver operating characteristic curve was generated to evaluate the accuracy of these miRNAs as molecular markers for breast cancer diagnosis. Furthermore, the functional role of these miRNAs was verified using cell experiments. Targets of candidate miRNAs were predicted using 9 online databases, and Gene Ontology (GO) functional annotation and pathway analyses were conducted using Database for Annotation, Visualization and Integrated Discovery online tool. Results: A total of 68 miRNAs showed significantly different expression patterns between the groups (p < 0.001), and 13 of these miRNAs were significantly associated with poor survival (p < 0.05). Three miRNAs with high specificity and sensitivity, namely, miR-148b-3p, miR-190b, and miR-429, were selected. In vitro experiments showed that the overexpression of these 3 miRNAs significantly promoted the proliferation and migration of MDA-MB-468 and T47D cells and reduced the apoptosis of T47D cells. GO and pathway enrichment analyses revealed that the targets of these dysregulated miRNAs were involved in many critical cancer-related biological processes and pathways. Conclusion: The miR-148b-3p, miR-190b, and miR-429 may serve as potential diagnostic and prognostic markers for breast cancer. This study demonstrated the roles of these 3 miRNAs in the initiation and progression of breast cancer.