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Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties
Huynh, Elizabeth,Lovell, Jonathan F.,Helfield, Brandon L.,Jeon, Mansik,Kim, Chulhong,Goertz, David E.,Wilson, Brian C.,Zheng, Gang American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.40
<P>Porphyrin–phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell (“porshe”), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin–lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3–5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9–10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-40/ja305988f/production/images/medium/ja-2012-05988f_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja305988f'>ACS Electronic Supporting Info</A></P>
In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging
Huynh, Elizabeth,Leung, Ben Y. C.,Helfield, Brandon L.,Shakiba, Mojdeh,Gandier, Julie-Anne,Jin, Cheng S.,Master, Emma R.,Wilson, Brian C.,Goertz, David E.,Zheng, Gang Nature Publishing Group, a division of Macmillan P 2015 Nature nanotechnology Vol.10 No.4
Converting nanoparticles or monomeric compounds into larger supramolecular structures by endogenous or external stimuli is increasingly popular because these materials are useful for imaging and treating diseases. However, conversion of microstructures to nanostructures is less common. Here, we show the conversion of microbubbles to nanoparticles using low-frequency ultrasound. The microbubble consists of a bacteriochlorophyll–lipid shell around a perfluoropropane gas. The encapsulated gas provides ultrasound imaging contrast and the porphyrins in the shell confer photoacoustic and fluorescent properties. On exposure to ultrasound, the microbubbles burst and form smaller nanoparticles that possess the same optical properties as the original microbubble. We show that this conversion is possible in tumour-bearing mice and could be validated using photoacoustic imaging. With this conversion, our microbubble can potentially be used to bypass the enhanced permeability and retention effect when delivering drugs to tumours.
Jeon, Mansik,Song, Wentao,Huynh, Elizabeth,Kim, Jungho,Kim, Jeesu,Helfield, Brandon L.,Leung, Ben Y. C.,Goertz, David E.,Zheng, Gang,Oh, Jungtaek,Lovell, Jonathan F.,Kim, Chulhong SPIE--the International Society for Optical Engine 2014 Journal of biomedical optics Vol.19 No.1
Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)