디지탈 통신 학습 시뮬레이터

송현교,김연구,이택희,강민구 호남대학교 정보통신연구소 1995 정보통신연구 Vol.4 No.-

본 논문에서는 실제 통신망에서 발생할 수 있는 데이타 전송과정을 컴퓨터상에 시뮬레이션하는 프로그램으로서, PC의 WINSOW 환경하에서 Visual-Basic을 활용하여 통신신호의 흐름과정을 하나의 화면에서 구현하도록 부호화와 변조파형을 표현하고 이 신호의 복조와 복호과정을 시뮬에이션한다. 아울러 통신채널에서 발생하는 랜덤오류를 제어하는 오류정정을 포함함으로서 통신이론을 이해하고 학습하는데 많은 도움이 될 수 있도록 통신신호에 대한 그래픽 처리에 목적을 둔다. In this thesis, the graphic signal for communication is presented in the WINDOW using `Visual-Basic'. All signals of PCM encoding/decoding and modulation/demodulation are processed in the same picture. Especially, error control schemes which are parity check, longiudinal redundancy check, cyclic redundancy check, are described for more reliable communication.

여성 경도 알쯔하이머형 치매군, 치매의심군 그리고 비치매 대조군간의 신경인지기능 비교

이은하,안석균,오병훈,김기현,이연희,오희철,김승민 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

알쯔하이머형 치매의 치료에 있어서 조기 진단과 조기 치료의 중요성이 강조되고 있다. 최근에는 임상적으로 치매의 진단 기준을 맞추지는 않으나 주관적인 기억력 저하의 호소와 인지적으로 정상이 아닌 치매의심군이란 개념이 소개되었으며, 1982년 Hughes등은 임상치매척도(Clinical Dementia Rating ; 이하 CDR)란 진단도구를 개발하여 그 CDR 점수가 0.5점인 대상을 치매의심군으로 정의하였다. 치매의심군에 대한 장기간의 추시를 통하여 치매의심군은 알쯔하이머형 치매의 매우 조기 단계(very early stage)일 것이라는 주장을 하는 연구 결과들이 있었다. 알쯔하이머형 치매의 진단에 현재까지 알려진 가장 예민한 도구는 적절한 문진(good history)과 신경인지기능학적 평가를 통한 이차성 기억력 특히 지연회상(delayed recall)의 장애를 확인하는 것이라고 알려져 있다. 이에 치매의심군을 진단하기 위해서 치매의심군의 신경인지기능학적 특징을 아는 것은 치매의심군의 진단과 치매로 진행할 지의 여부를 결정짓는 예측인자를 정하는 데에도 도움이 될 것이다. 본 연구는 경도 알쯔하이머형 치매군, 치매군 및 비치매 대조군 간의 주의력, 기억력, 시지각공간능력, 언어능력 및 고위피질기능 등의 신경인지기능을 비교함으로써 치매의심군의 신경인지기능적 특성을 알아보고자 하였다. 본 연구의 대상은 경기도 광주군 정신보건센터의 노인 낮병원 등록된 65세 이상의 여성 노인 중 경도 알쯔하이머형 치매군 5명, 치매의심군 9명 및 비치매 대조군 14명을 대상으로 하였다. 혈관성 치매를 배제하기 위해 Hachinski 허혈지수상 4점이 넘는 경우와 우울증상의 신경인지기능 평가에 대한 영향을 배제하기 위해 단축형노인우울척도(Short form Geriatric Depression Scale ; 이하 SGDS)상 8점이 넘는 경우는 연구 대상에서 제외하였다. 진단은 노인 낮병원 퇴원시점에서 치매연구회의(노인정신과 전문의, 정신과 전문의, 전공의, 임상심리사, 사회사업사, 간호가 각 1인으로 구성)에 의해 진단과 통계편람 Ⅳ 판(Diagnostic and Statistical Manual ; 이하 DSM-Ⅳ) 및 CDR을 기준으로 내렸다. 주의력은 Wechsler 기억검사 수정판(Wechsler, 1987 ; 이하 WMS-R)의 소검사인 숫자따라하기(Digit span), 도형따라짚기(Visual span) 및 비엔나검사총집(Schufried, 1993 : 이하 Vienna test system)의 소검사인 지속적주의력(Continuous attention)을 이용하여 평가하였다. 기억력은 WMS-R의 논리적기억력(Logical memory)의 즉각회상(Immediate recall)과 30분 지연회상(delayed recall), 언어적연상학습(verbal paired associate learning)의 즉각회상-쉬운짝연상(easy pair)/어려운짝연상(hard pair), 30분 지연회상-쉬운짝연상/어려운짝연상을 이용하여 평가하였다. 시지각공간능력 중에서 시지각능력(Visual perception)은 WMS-R의 시각기억검사를 응용하여 평가하였고, 시공간능력(Visuospatial abilities)은 신경행동학적인지상태검사(Neurobehavioral Cognitive Screening Examination : 이하 NCSE)의 구성능력검사(Construction)을 이용하여 평가하였다. 언어능력은 한국판 성인용개인지능검사(Korean-Wechsler Adult Intelligence Scale : 이하 K-WAIS)의 이해력검사(Comprehension) 및 한국신경인지기능연구회의 신경인지검사집상의 실어증등급척도(Aphasia severity rating scale)를 이용하여 평가하였다. 고위피질기능(Higher cortical function)은 NCSE의 유사성검사(Similarity), 판단력검사(Judgment), Go-No-Go 검사, Vienna test system의 가설형성검사(Hypotheis formation test), 부속증검사(Perseveration test)를 이용하여 평가하였다. 진단을 독립변수로 , 각종 신경인지기능검사의 결과를 종속변수로 설계하여 one-way ANOVA를 실시하였고, 유의한 차 이를 보인 종속변수에 대해서는 사후분석을 실시하였다. 경도 알쯔하이머형 치매군 5인, 치매 의심군 9인 및 비치매 대조군 14인을 대상으로 신경인지기능을 평가한 결과, 언어적연상학습의 즉각회상 중에서 쉬운짝연상(경도 치매군, 치매의심군, 대조군 각각 4.80±3.34,6.0±2.0, 8.85±2.14),구성능력검사(0.50±0.58, 1.00±1.55, 3.50±1.87), 실어증등급척도(2.83±0.40, 3.78±0.67, 4.71±0.47), 유사성검사(2.80±3.56, 2.11±1.54, 7.36±1.98)에서 치매의심군은 정상대조군에 비해 유의하게 저조한 수행을 보였고, 경도치매군과는 수행정도 상 유의미한 차이를 보이지 않았다. 이는 치매의심군의 인지적 특성이 정상노화보다는 알쯔하이머형 치매에 가깝다는 것을 시사한다. 따라서 치매의심군은 정상 노화라기 보다는 알쯔하이머형 치매의 전단계일 가능성이 시사된다. The objective of this study is to differentiate the mild dementia of Alzheimer type from the questionable dementia and non-demented elderly using the neurocognitive assessment. Subjects of 28 women who were registered to Kwangju Community Mental Health Center were as follow : 14 non-demented, 9 questionable dementia, 5 mild dementia of Alzheimer type. The diagnosis were made using DSM-Ⅳ, Clinical Dementia Rating Scale. The neurocognitive functions were assessed with following test tools 1) attention : Digit span, Visual span, Continuous attention ; 2) memory : Logical memory, Verbal paired associates-easy/hard 3) visual perception and visuospatial ability : Visual recognition test, Construction ; and 4) language : Comprehension and Aphasia severity rating scale ; 5) higher cortical function : Hypothesis formation, Perseveration, Similarity, Judgment, and Go-No-Go test. Group differences were analyzed with one way ANOVA test in SPSS 8.0 for win and LSD method as post-hoc analysis. The questionable dementia group showed significant difference in Verbal paired associates-easy pair, Construction, Aphasia severity rating scale and Similarity from the non-demented normal control group but showed no difference from the mildly demented group. These results suggest that the questionable dementia is actually very early or very stage of dementia of the Alzheimer type.

Gadolinium Complex of DO3A-benzothiazole Aniline (BTA) Conjugate as a Theranostic Agent

Kim, Hee-Kyung,Kang, Min-Kyoung,Jung, Ki-Hye,Kang, Sun-Hee,Kim, Yeoun-Hee,Jung, Jae-Chang,Lee, Gang Ho,Chang, Yongmin,Kim, Tae-Jeong American Chemical Society 2013 Journal of medicinal chemistry Vol.56 No.20

<P>A gadolinium complex of 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) and benzothiazole-aniline (BTA) of the type [Gd(DO3A-BTA)(H<SUB>2</SUB>O)] has been prepared for use as a single molecule theranostic agent. The kinetic inertness and <I>r</I><SUB>1</SUB> relaxivity (= 3.84 mM<SUP>–1</SUP> s<SUP>–1</SUP>) of the complex compare well with those of structurally analogous Gd-DOTA. The same complex is not only tumor-specific but also intracellular, enhancing MR images of cytosols and nuclei of tumor cells such as MCF-7, MDA-MB-231, and SK-HEP-1. Both DO3A-BTA and Gd(DO3A-BTA) reveal antiproliferative activities as demonstrated by GI<SUB>50</SUB> and TGI values obtainable from the cell counting kit-8 (CCK-8) assays performed on these cell lines. Ex vivo and in vivo monitoring of tumor sizes provide parallel and supportive observations for such antiproliferative activities.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2013/jmcmar.2013.56.issue-20/jm401206t/production/images/medium/jm-2013-01206t_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm401206t'>ACS Electronic Supporting Info</A></P>

Naringenin Derivative Diethyl (5,4'-dihydroxy flavanone-7-yl) Phosphate Inhibits Cell Growth and Induces Apoptosis in A549 Human Lung Cancer Cells

Kim, Jung-Hee,Kim, Hee-Jong,Bak, Ye-Sol,Kang, Jeong-Woo,Lee, Dong-Hun,Kim, Man-Sub,Park, Yun-Sun,Kim, Eun-Jin,Jung, Kang-Yeoun,Lim, Yoong-Ho,Hong, Jin-Tae,Yoon, Do-Young The Korean Society for Applied Biological Chemisty 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.1

Anti-cancer effects of naringenin derivative diethyl (5,4'-dihydroxy flavanone-7-yl) phosphate were evaluated in human lung cancer cells. The effect of diethyl (5,4'-dihydroxy flavanone-7-yl) phosphate (dEdHF-7-p) on A549 cell viability was measured using MTS assay and cell counting. Morphological changes were detected using phase-contrast microscopy. Apoptosis was analyzed using Hoechst staining. The influence of dEdHF-7-p on cell cycle distribution was determined using propidium iodide (PI) staining, and protein expression was determined by Western blot analysis. A newly synthesized naringenin derivative dEdHF-7-p suppressed cell growth of A549 though mechanisms including inhibition of cell cycle and increased apoptosis. Apoptotic and cell cycle modulators were changed by dEdHF-7-p in A549 cells; cyclins, ppRB, and anti-apoptotic factor Bcl-2 were down-regulated, whereas apoptotic factor Bax and cyclin-dependent kinase inhibitors p21 and p53 were enhanced, thereby releasing cytochrome c into the cytosol of dEdHF-7-p-treated-A549 cells. dEdHF-7-p treatment processed caspases-3/-8/-9 and cleavage of poly ADP-ribose polymerase. The dEdHF-7-p treatment enhanced Fas expression and decreased expression of cell survival factors such as PI3K and p-Akt in a dose-dependent manner. Taken together, dEdHF-7-p induces apoptosis by inhibiting the PI3K/Akt survival signaling pathway and modulating mitochondria-emanated intrinsic and Fas extrinsic pathways in A549 cells.

MBTI 성격유형에 따른 산림치유 프로그램 선호도에 관한 연구

김윤희 ( Youn Hee Kim ),김동준 ( Dong Jun Kim ),김은진 ( Eun Jin Kim ),연평식 ( Pyung Sik Yeoun ),최병진 ( Byung Jin Choi ),김재근 ( Jea Kean Kim ),김윤수 ( Youn Soo Kim ) 한국환경생태학회 2015 한국환경생태학회지 Vol.29 No.3

산림치유 프로그램에 대한 요구가 증가되고 있다. 효과적인 산림치유를 위해, 참가자의 특성을 파악하여 보다 표적화 되고 차별화된 산림치유 프로그램을 개발, 운영할 필요가 있다. 이에, 본 연구에서는 개인의 성격에 기초한 산림치유 프로그램의 개발 및 운영을 위한 기초자료 제공을 목적으로, MBTI(Myers-Briggs Type Indicator) 성격유형 선호지표, 심리기질유형과 산림치유 프로그램의 선호도 사이의 관련성을 각각 분석하였다. 일반 성인 남·여 245명을 대상으로 MBTI 성격검사와 산림치유 프로그램에 관한 선호도 설문조사를 실시하였다. 자료분석은 SPSS 21.0 프로그램을 사용하여 분산분석(ANOVA)을 통해 MBTI 성격유형에 따른 산림치유 프로그램 선호도의 차이를 살펴본 바, 그 차이가 확인되었다. 외향(E)-내향(I)은 호흡법·호흡체조, 자유롭게 숲속 걷기(신발착용), 숲속 웃음치료, 경관보기, 삼림욕, 풍욕, 일광욕에 대해 통계적으로 유의한 차이가 있었다. 그리고 감각(S)-직관(N)은 물 흐르는 소리 듣기, 허브차 마시기, 숲속 잠자기에 대해, 사고(T)-감정(F)은 물속에 발과 팔 담그기, 숲속 잠자기에 대해, 판단(J)-인식(P)은 비전세우기, 경관보기에 대해 각각 통계적으로 유의한 차이가 있는 것으로 나타났다. 성격의 심리기질유형에 따라서, 허브차 마시기, 자연음식 먹기, 숲속 잠자기, 경관보기, 숲 해설 듣기에 대해 통계적으로 유의한 차이가 있는 것으로 나타났다. 본연구 분석 결과가 산림치유 프로그램 개발과 운영을 위한 기초자료로 활용되기를 기대한다. The need for forest therapy programs has been increasing. For more effective forest healing, it is necessary to identify the characteristics of participants and develop and operate more targeted and differentiated forest therapy programs accordingly. In this study, the relationships between MBTI (Myers-Briggs Type Indicator) personality types and the relationship between the temperaments of MBTI and the preference for the forest therapy programs were analyzed respectively in pursuit of the basic data required for the effective development and operation of forest healing on the basis of individual characteristics. The survey on the forest therapy program and MBTI personality tests were conducted for 245 normal adults. Using the SPSS 21.0 program analysis, data were analyzed by Analysis of variance (ANOVA) to obtain the difference of preference on the forest therapy program according to the personality type. The Extraversion(E)-Introversion(I) types showed differences in technique-based breathing exercises, walking in the forest(wearing shoes), laughter therapy in the forest, viewing the forest, forest bathing, wind bathing and sun bathing. And the Sensing(S)-iNtuition (N) types had marked differences in listening to the sound of water flowing, drinking herbal tea and sleeping in the forest. The Thinking (T) -Feeling (F) types marked differences in soaking hands and feet in water and sleeping in the forest. The Judging (J)-Perceiving (P) types had differences in vision quest and viewing the forest, respectively, in statistics. Depending on the temperament of the character, there were statistically significant differences in preferences such as drinking herbal tea, eating natural food, sleeping in the forest, viewing the forest and listening to the forest commentary. The results of this study are expected to be used as a basis for forest healing program development and operation.

Women with Fibromyalgia Have Lower Levels of Calcium, Magnesium, Iron and Manganese in Hair Mineral Analysis

Kim, Young-Sang,Kim, Kwang-Min,Lee, Duck-Joo,Kim, Bom-Taeck,Park, Sat-Byul,Cho, Doo-Yeoun,Suh, Chang-Hee,Kim, Hyoun-Ah,Park, Rae-Woong,Joo, Nam-Seok The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.10

<P>Little is known about hair mineral status in fibromyalgia patients. This study evaluated the characteristics of hair minerals in female patients with fibromyalgia compared with a healthy reference group. Forty-four female patients diagnosed with fibromyalgia according to the American College of Rheumatology criteria were enrolled as the case group. Ageand body mass index-matched data were obtained from 122 control subjects enrolled during visit for a regular health check-up. Hair minerals were analyzed and compared between the two groups. The mean age was 43.7 yr. General characteristics were not different between the two groups. Fibromyalgia patients showed a significantly lower level of calcium (775 µg/g vs 1,093 µg/g), magnesium (52 µg/g vs 72 µg/g), iron (5.9 µg/g vs 7.1 µg/g), copper (28.3 µg/g vs 40.2 µg/g) and manganese (140 ng/g vs 190 ng/g). Calcium, magnesium, iron, and manganese were loaded in the same factor using factor analysis; the mean of this factor was significantly lower in fibromyalgia group in multivariate analysis with adjustment for potential confounders. In conclusion, the concentrations of calcium, magnesium, iron, and manganese in the hair of female patients with fibromyalgia are lower than of controls, even after adjustment of potential confounders.</P>

Electro-Thermal Modeling and Experimental Validation of Integrated Microbolometer with ROIC

Kim, Gyungtae,Kim, Taehyun,Kim, Hee Yeoun,Park, Yunjong,Ko, Hyoungho The Institute of Electronics and Information Engin 2016 Journal of semiconductor technology and science Vol.16 No.3

This paper presents an electro-thermal modeling of an amorphous silicon (a-Si) uncooled microbolometer. This modeling provides a comprehensive solution for simulating the electro-thermal characteristics of the fabricated microbolometer and enables electro-thermal co-simulation between MEMS and CMOS integrated circuits. To validate this model, three types of uncooled microbolometers were fabricated using a post-CMOS surface micromachining process. The simulation results show a maximum discrepancy of 2.6% relative to the experimental results.

Cutaneous Infection by Fusarium solani Associated with Arteriosclerosis Obliterans in an Immunocompetent Patient

Hee Jung Kim,June Woo Kim,Ji Yeoun Lee,Mi Kyeong Kim,Tae Young Yoon 대한피부과학회 2007 Annals of Dermatology Vol.19 No.3

Kaposi`s Varicelliform Eruption Complicating Lichen Simplex Chronicus

Hee Jung Kim,Jeong Hyun Yun,Ji Yeoun Lee,Mi Kyeong Kim,Tae Young Yoon 대한피부과학회 2007 Annals of Dermatology Vol.19 No.3

Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells

KIM, YEOUN-HEE,JUNG, JAE-CHANG Spandidos Publications 2012 ONCOLOGY REPORTS Vol.28 No.5

<P>CD44v6 has been shown to coordinate the activation of anti-apoptotic molecules as well as resistance to apoptosis. Here, we investigated CD44v6 ectodomain shedding in Caki-2 human renal carcinoma cells as well as its underlying mechanisms. Exposure of cells to tunicamycin (TM)-induced apoptosis was accompanied by cleavage of caspase-3, PARP-1 and CD44v6 ectodomain. TM-induced apoptosis was also closely associated with endoplasmic reticulum (ER) stress, as shown by increased expression of GRP-78 and CHOP proteins. Furthermore, induction of matrix metallo-proteinase (MMP)-13, MMP-9 and ADAM10 expression was highly stimulated by tunicamycin in a time- and dose-dependent manner. TM-induced PARP-1 cleavage was significantly inhibited by treatment with GM6001 (a broad spectrum MMP inhibitor), MMP-9/-13 inhibitor and GI254023X (specific ADAM10 inhibitor). In addition, inhibition of all examined MMPs resulted in reversal of TM-induced apoptosis as well as increased cell viability. When considering the functional implications of MMP-9 and ADAM10, it is likely that active MMP-9 and ADAM10 help regulate the cellular levels of CD44v6 through cleavage of CD44v6 ectodomain during TM-induced apoptosis of Caki-2 cells. Collectively, these findings suggest that multiple TM-induced MMPs may cooperate to induce apoptosis.</P>