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- 검색키워드
- 저자 : Hedin, E. R. (검색결과 4 건)
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정희진(Hedin Jung),정충영(Choong-yeung Jung) 한국컴퓨터정보학회 2004 韓國컴퓨터情報學會論文誌 Vol.9 No.4
본 연구에서는 정보시스템 프로젝트 계획모형에서의 가능성 계획법 적용을 제시하고 있다. 정보시스템 프로젝트 계획모형에서 관리자와 의사결정자들은 불명확한 정보나 주관적 견해로 인해 흔히 일정계획, 비용, 성능(품질)과 같은 모수의 추정에서 많은 어려움을 겪게 된다. 이러한 경우 가능성 의사결정모형은 현실적 의사결정모형에서 적용 가능한 해법을 제시할 수 있게 된다. 본 연구에서 적용된 CPM은 프로젝트가 완료되는 시점을 결정하고 프로젝트를 수행하기 위해 각 활동들의 수행시작 일정을 수립하는 데 목적이 있는 기법이다. 가능성 계획법을 적용한 CPM(Critical Path Method)에서는 의사결정자의 열망수준, 의사결정상의 애매함을 고려할 수 있으며, 계산상의 효율성도 제고할 수 있다. 본 모형은 GINO을 이용하여 해를 구하였으며, 수치 예와 해가 제시되어졌다.<br/> This paper presents a practical application of possibilistic programming in a information system projects planning model. The estimate of the parameters of the model is often a problematic task for the decision maker(DM). Who has imprecise information or express his considerations subjectively. In this case. possibilistic decision making models can provide an important aspect in handling practical decision making problems. We suggest CPM(Critical Path Method) applying possibilistic programming. CPM is an approach to planning and coordinating large projects by directing managerial focus to the project's most critical aspects and providing completion time of project and beginning time of each activity. This model is an aid in the control of considering aspiration levels by the DM, the fuzziness of decision making. and computational efficiency. The problem is solved by using GINO computer package and the best compromised solution is found.<br/> <br/>
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Electromagnetic compatibility of aperture antennas using electromagnetic band gap structure
Essiben, J-F D.,Hedin, E. R.,Kim, Y. D.,Joe, Y. S. IET 2012 IET microwaves, antennas & propagation Vol.6 No.9
<P>A rigorous solution to the problem of coupling reduction between the receiving and transmitting aperture antennas by using an electromagnetic band gap (EBG) structure is theoretically and experimentally investigated. The estimation of the decoupling level for the synthesised EBG structure is given. The radiation patterns of both the antennas are also presented. The moment method is used to solve the integral equations. Finally, the authors perform an experiment on the frequency dependence of the decoupling level and compare numerical and experimental results. Good agreement between simulation and measurement is achieved.</P>
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박세라,신용규,이경진,이정환,David HEDIN,Thera MULVANIA,이승호,고기성 한국곤충학회 2014 Entomological Research Vol.44 No.1
Colorectal cancer is a commonly diagnosed cancer in the world. Monoclonal antibody (mAb) CO17‐1A recognizes the tumor‐associated antigen GA733, a cell surface glycoprotein highly expressed in colorectal carcinoma cell, which is considered to be applicable for diagnosis and therapeutic treatment against colorectal cancer. In addition antibodies are glycoproteins, efficiently recognize and eliminate specific pathogenic and disease antigens. We have currently established baculovirus insect cell expression system to produce anti‐colorectal cancer mAb CO17‐1A. In this study, mAb CO17‐1A was expressed in the transgenic insect cell line SfSWT4, in which glycosylation processing pathway has been humanized. Immunoblot confirmed that mAb CO17‐1A properly expressed in SfSWT4 insect cells. mAb CO17‐1A was purified using protein G affinity column. In addition, MALDI‐TOF verified that the mAb CO17‐1A fused to KDEL, endoplasmic reticulum (ER) retention signal (mAb CO17‐1AK) had high mannose type of glycan structure. Migration assay showed that insect cell‐derived mAb CO17‐1AK (mAbI CO17‐1AK) with high mannose type of glycan structure was effective as mammalian‐derived mAb CO17‐1A (mAbM CO17‐1A) in inhibition of metastasis. Kinetic analysis of antigen‐antibody interaction using Surface Plasmon Resonance (SPR) confirmed that mAbI CO17‐1AK is efficient to interact with antigen GA733 as mAbM CO17‐1A. These results suggest that the insect cell expression system with the SfSWT4 possibly can be used as a useful alternative way to produce full‐size mAb for cancer immunotherapy.
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Expression and function of recombinant anti-colorectal cancer mAb CO17-1A in SfSWT4 insect cells
Se-Ra Park,Kyung Jin Lee,Jeong-Hwan Lee,David Hedin,Thera Mulvania,Seung Ho Lee,Kisung Ko 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Colorectal cancer is the third most commonly diagnosed cancer in the world, nearly all patients diagnosed with this cancer die from it. Antibodies are glycoprotein molecules, which can efficiently recognize and eliminate specific pathogenic and disease antigens. Antibody researches for the last several decades have demonstrated the potential of therapeutic antibodies to fight cancer. Monoclonal antibody (mAb) CO17-1A recognizes the tumor-associated antigen GA733-2, a cell surface glycoprotein highly expressed in colorectal carcinoma cell, which is applicable for preventing and curing colorectal cancer. We have currently established baculovirus insect cell expression system to produce anti-colorectal cancer mAb CO17-1A. In this study, mAb CO17-1A was expressed in the transgenic insect cell line SWT4, which has humanized glycosylation processing pathway. Immunoblot confirmed that mAb CO17-1A properly expressed in SWT4. mAb CO17-1A was purified using protein G affinity column. In addition, Maldi-TOF verified that the mAb fused to KDEL, ER retention signal had high mannose type of glycan structure whereas the mAb without KDEL had partially humanized glycan structure. These results suggest that the insect cell expression system with the SWT4 possibly can be used as a useful alternative way to produce full-size mAb with humanized glycan structures for cancer immunotherapy.
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