http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hayden Matthews (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
Three Concurrent Periprosthetic Joint Infections: A Case Report and Literature Review
Matthew Pina,Alexander D. Gaukhman,Brett Hayden,Eric L. Smith 대한고관절학회 2019 Hip and Pelvis Vol.31 No.1
Periprosthetic joint infections are a major cause of morbidity and mortality following total joint arthroplasty. Two-stage arthroplasty, with the use of an antibiotic cement spacer, is an effective means of managing periperiprosthetic joint infections. There is a lack of data relating to the management, prognosis, and clinical outcomes associated with multiple peri-prosthetic joint infections. Here, we present a case report of a patient successfully treated for three synchronic peri-prosthetic joint infections of both knees and a single hip.
-
Radiologically inserted gastrostomy complications: A case series
George Zhang,Hayden Matthews,Osanna Wong,Dylan Kurda 소화기인터벤션의학회 2022 Gastrointestinal Intervention Vol.11 No.3
Radiologically inserted gastrostomy (RIG) is performed in patients who cannot safely or sufficiently receive oral nutrition; however, postoperative complications are not uncommon. The risk of major complications such as peritonitis, migration, infection, malposition, and bleeding is small but appreciable, although mortality as a direct consequence of gastrostomy placement is rare. In this case series, we describe the major gastrostomy complications (arterial haemorrhage, gastric fluid leak, peritonitis, RIG site infection, ileus and colon perforation) that occurred in four patients at our hospital over a 27-month period in which 152 RIG procedures were performed (an incidence rate of 2.6%). Herein, we describe the gastrostomy procedures, clinical course, and surgical corrections required for these patients before discussing the complication risks for common gastrostomy procedures and potential methods to reduce and prevent such complications.
-
Radiologically inserted gastrostomy complications: A case series
George Zhang,Hayden Matthews,Osanna Wong,Dylan Kurda 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.3
Radiologically inserted gastrostomy (RIG) is performed in patients who cannot safely or sufficiently receive oral nutrition; however, postoperative complications are not uncommon. The risk of major complications such as peritonitis, migration, infection, malposition, and bleeding is small but appreciable, although mortality as a direct consequence of gastrostomy placement is rare. In this case series, we describe the major gastrostomy complications (arterial haemorrhage, gastric fluid leak, peritonitis, RIG site infection, ileus and colon perforation) that occurred in four patients at our hospital over a 27-month period in which 152 RIG procedures were performed (an incidence rate of 2.6%). Herein, we describe the gastrostomy procedures, clinical course, and surgical corrections required for these patients before discussing the complication risks for common gastrostomy procedures and potential methods to reduce and prevent such complications.
-
T Regulatory Cells Maintain Intestinal Homeostasis by Suppressing γδ T Cells
Park, Sung-Gyoo,Mathur, Ramkumar,Long, Meixiao,Hosh, Namiko,Hao, Liming,Hayden, Matthew S.,Ghosh, Sankar Elsevier 2010 Immunity Vol.33 No.5
<P><B>Summary</B></P><P>Immune tolerance against enteric commensal bacteria is important for preventing intestinal inflammation. Deletion of phosphoinositide-dependent protein kinase 1 (<I>Pdk1</I>) in T cells via <I>Cd4-Cre</I> induced chronic inflammation of the intestine despite the importance of PDK1 in T cell activation. Analysis of colonic intraepithelial lymphocytes of PDK1-deficient mice revealed markedly increased CD8α<SUP>+</SUP> T cell receptor (TCR)γδ<SUP>+</SUP> T cells, including an interleukin-17 (IL-17)-expressing population. TCRγδ<SUP>+</SUP> T cells were responsible for the inflammatory colitis as shown by the fact that deletion of <I>Tcrd</I> abolished spontaneous colitis in the PDK1-deficient mice. This dysregulation of intestinal TCRγδ<SUP>+</SUP> T cells was attributable to a reduction in the number and functional capacity of PDK1-deficient T regulatory (Treg) cells. Adoptive transfer of wild-type Treg cells abrogated the spontaneous activation and proliferation of intestinal TCRγδ<SUP>+</SUP> T cells observed in PDK1-deficient mice and prevented the development of colitis. Therefore, suppression of intestinal TCRγδ<SUP>+</SUP> T cells by Treg cells maintains enteric immune tolerance.</P> <P><B>Highlights</B></P><P>► PDK1 is essential for Treg cell function including suppression and IL-10 production ► γδ T cells can cause colitis, even in the absence of functional αβ T cells ► γδ T cell-mediated colitis depends on the presence of commensal bacteria ► Treg cells can directly suppress γδ T cells through the production of IL-10</P>
-
Kang, Jung-Ah,Jeong, Sang Phil,Park, Daeho,Hayden, Matthew S.,Ghosh, Sankar,Park, Sung-Gyoo The American Association of Immunologists, Inc. 2013 JOURNAL OF IMMUNOLOGY Vol.190 No.9
<P>Strong NF-κB activation requires ligation of both the CD28 coreceptor and TCR. Phosphoinositide-dependent kinase 1 (PDK1) acts as a scaffold by binding both protein kinase Cθ (PKCθ) and CARMA1, and is therefore essential for signaling to NF-κB. In this article, we demonstrate the importance of PDK1 Thr<SUP>513</SUP> phosphorylation in regulating the intermolecular organization of PDK1 homodimers. Thr<SUP>513</SUP> is directly involved in heterotypic PDK1 homodimer formation, in which binding is mediated through the pleckstrin homology (PH) and kinase domains. Upon activation, phosphorylated Thr<SUP>513</SUP> instead mediates homotypic intermolecular binding through the PH domains. Consequently, cell-permeable peptides with a Thr<SUP>513</SUP> to Ile derivative (protein transduction domain [PTD]-PDK1-Thr<SUP>513</SUP>-Ile) bound the kinase domain, whereas a Thr<SUP>513</SUP>-to-Asp peptide (PTD-PDK1-Thr<SUP>513</SUP>-Asp) bound the PH domain. PTD-PDK1-Thr<SUP>513</SUP>-Ile blocked binding between PDK1 and PKCθ, phosphorylation of PKCθ Thr<SUP>538</SUP>, and activation of both NF-κB and AKT. In contrast, PTD-PDK1- Thr<SUP>513</SUP>-Asp selectively inhibited binding between PDK1 and CARMA1, and blocked TCR/CD28-induced NF-κB activation. Therefore, Thr<SUP>513</SUP> phosphorylation regulates a critical intermolecular switch governing PDK1 homodimer structure and the capacity to interact with downstream signaling pathway components. Given the pleiotropic functions of PDK1, these data may open the door to the development of immunosuppressive therapies that selectively target the PDK1 to NF-κB pathway in T cell activation.</P>
KCI
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
