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- 저자 : Hartavi, Mustafa (검색결과 3 건)
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Hartavi, Mustafa,Kurt, Ender,Oral, Barbaros,Olmez, Omer Fatih,Cubukcu, Erdem,Deligonul, Adem,Avci, Nilufer,Manavoglu, Osman Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Suppressor of cytokine signaling (SOCS)-1 acts as a key regulator of many cytokine signaling pathways and its abnormal expression has been identified in several human malignancies, suggesting potential roles in carcinogenesis. The aim of this study was to investigate any association between the functional SOCS-1 -1478CA>del polymorphism and colorectal cancer (CC) as well as age at onset in a Turkish clinical sample. Materials and Methods: A total of 122 subjects were enrolled in this case-control study (70 CC cases and 52 controls). The SOCS-1 -1478CA>del polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The odds ratio of the del allele for CC relative to the CA allele was not significantly different between the groups (OR=0.71, 95% CI=0.41-1.22, p=0.27). This result did not change after adjustment for age and sex on multivariable regression analysis (OR=0.84, 95% CI=0.59-1.34, p=0.53). When the SOCS-1 -1478CA>del polymorphism was analyzed among CC patients in relation to the age at disease onset, we found no significant differences between subjects with the del/del, CA/del, and CA/CA genotypes. Conclusions: The results of our study did not point towards a major role of the SOCS-1 -1478CA>del polymorphism in the pathogenesis of CC in Turkish subjects.
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Rini Gabriele,De Bernardis Martino,Bottiglione Francesco,Hartavi Ahu Ece,Sorniotti Aldo 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.4
A significant body of literature discusses direct yaw moment controllers for vehicle stability control and torque-vectoring (TV), based on model predictive control. However, the available references lack an analysis of the effect of including or excluding the wheel dynamics in the prediction model in combined longitudinal and lateral acceleration conditions, which is related to the control system architecture. In fact, in the first case, the controller can also fulfill the wheel slip control function, according to a centralized architecture, while in the second case, the tire slip limitation has to be implemented externally, in a multi-layer approach. This study addresses the identified gap by proposing and comparing – through simulations with a high-fidelity vehicle model – centralized and multilayer real-time implementable architectures using nonlinear model predictive control (NMPC) for the TV and traction control (TC) of an electric vehicle with front in-wheel motors. An optimization routine calibrates the main controller parameters, to ensure fairness in the comparison during extreme accelerating-while-cornering maneuvers with transient steering inputs. The results show that the real-time implementable multi-layer architecture with wheel dynamics in the NMPC prediction model, and considering the externally generated TC torque reduction in the TV layer, provides equivalent performance to a centralized set-up.
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Olmez, Omer Fatih,Evrensel, Turkkan,Cubukcu, Erdem,Ugras, Nesrin,Avci, Nilufer,Canhoroz, Mustafa,Deligonul, Adem,Hartavi, Mustafa,Olmez, Fatma,Cubukcu, Sinem,Tolunay, Sahsine,Kurt, Ender,Kanat, Ozkan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Background: Previous reports have shown that human epidermal receptor (HER)-3 overexpression may be associated with poor prognosis in patients with breast cancer, but results have been conflicting. In this study, we sought to investigate the prognostic significance of HER-3 immunohistochemical expression in patients with metastatic breast cancer. Methods: We retrospectively analyzed HER-3 immunohistochemical expression profiles in 45 paraffin-embedded specimens from patients who had been treated between 1996 and 2006 in the Department of Oncology of the Uludag University School of Medicine, Bursa, Turkey. Membranous or cytoplasmic dominant expression patterns of HER-3 were analyzed using the Rajkumar score and a cytoplasmic 4-point scoring system, respectively. Progression-free survival (PFS) and overall survival (OS) served as the main outcome measures. Results: The median PFS in the study participants was 9 months (interquartile range: 4.5-13 months), whereas the median OS was 20 months (interquartile range: 7.5-28 months). Categorization of the patient population according to HER-3 positive immunohistochemical expression did not reveal any statistically significant difference in terms of both PFS (p=0.70) and OS (p=0.81). The results of multivariable Cox regression analysis indicated that tumor size was the only independent predictor of PFS, whereas estrogen and progesterone receptor status was independently associated with OS. Conclusions: HER-3 immunohistochemical expression did not correlate with outcomes in Turkish patients with metastatic breast cancer. Although our results suggest that HER-3 expression in cancer specimens is not of prognostic significance, further prospective studies are warranted to confirm these results.
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