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The Influence of a Secretolytic Drug on Mucociliary Clearance of the Maxillary Sinus
Oliver Kaschke,Hans Behrbohm,Karin Sydow 대한비과학회 1997 Journal of rhinology Vol.4 No.1
To date, there has not been sufficient experimental evidence to demonstrate the pharmacological effect of secretolytic and mucolyticdrugs. Scintigraphic studies to detect the mucociliary clearance in the maxillary sinus before and after application of asecretolytic drug (Gelomyrtol® forte, G.Pohl-Boskamp, Hohenlockstedt, Germanym) were perfomed on four healthy persons andone patient having undergone sinus surgery. The most important parameters was the mucociliary transport velocity of the“regionof interest-maxillary sinus”and the increase of radioactivity accumulated in a swab placed in the middle nasal meatus. Measurements were done with a gamma-camera, 99m Technetium-sulphur colloid was used as the radiopharmacon. A dose of1 Mbq in 0.2 ml NaCl-solution was injected into the maxillary sinus. The results showed a clear increase of mucociliary transportvelocity in the maxillary sinus after intake of secretolytics in connection with an increase of radioactivity in the swab. The results can be explained by the secretolytic and secretomotoric effects of the investigated drug. The study reveals that etherealoils have secretolytic effects and also have a pharmacological effect on the mucociliary apparatus.