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- 저자 : Hamid Kooshki (검색결과 1 건)
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Mohammad Reza Safaee-Ardakani,Ashrafalsadat Hatamian-Zarmi,Seyedeh Mahdieh Sadat,Zahra Beagom Mokhtari-Hosseini,Bahman Ebrahimi-Hosseinzadeh,Hamid Kooshki,Jamal Rashidiani 한국섬유공학회 2019 Fibers and polymers Vol.20 No.12
The use of natural polymers and electrospinning as a new method of wound dressing production is one of thethings that can revolutionize the medical world. Due to the importance of wound healing and characteristics such as antiinflammatoryand antimicrobial properties, it is possible to use natural compounds such as fungi and metabolites derivedfrom them to produce wound dressing. In this study, schizophyllan (SPG) as an extracellular polysaccharide was extractedfrom Iranian Schizophyllum commune (NCBI MG761830) and then the silver nanoparticles (AgNPs) were produced by thein-situ method in 1.5 % SPG solution. Afterward, they were combined with polyvinyl alcohol 10 % (PVA) polymer tostrengthen the fiber structure. We investigated the properties of nanofibers containing PVA/SPG-AgNPs and PVA/SPG20 %. The physicochemical properties of two fibers were investigated by SEM, TEM, FTIR, contact angle, water uptake,nanoparticle release, and biological test (antibacterial, and MTT). The diameter of the nanofiber-containing the AgNPs wasabout 169 nm and the other nanofiber was about 212 nm. The highest inhibition of the growth of the bacterium by PVA/SPGAgNPsagainst E. coli and S. aureus was about 88.34 % and 64.7 %, respectively. The silver ion release from PVA/SPGAgNPsnanofibers was 21 μg/ml after fifth day. Both nanofibers had no toxic effect on L929 fibroblast cells.
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