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Hamdy Abdelkader,Usama Farghaly,Hossam Moharram 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.5
This study aimed at investigating the roles ofboth Span surfactant type (having a gel/liquid transitiontemperature range from\10 to 55 C), and cholesterol levelon in vitro characteristics and in vivo performance oftimolol maleate niosomes. Span 20, Span 40 and Span 60niosomes were prepared using the thin film hydrationmethod. Span:cholesterol levels employed were 7:3 mol/mol(a minimum concentration for stable niosomes) and1:1 mol/mol (a maximum concentration accommodated byniosomes). Niosomes were characterized for size, percentageentrapment efficiency, morphology, in vitro release andintra-ocular pressure (IOP) lowering activity in rabbits. Theorder of the area under IOP-time curve (AUC) was rankedas follows: Span 40[Span 20[Span 60. The AUC andIOPmax values for Span 40:cholesterol (7:3) niosomes weresuperior due to having a good compromise between thermoresponsivenessand efficient capacity for loading a significantdrug cargo, compared with Span 20 and Span 60.
Hamdy Abdelkader,Heba A. Hazzah,Magda A. EL-Massik,Ossama Y. Abdallah 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.4
Pellets are one of multiparticulate pharmaceutical forms and can offer numerous technical and biopharmaceutical advantages compared with single dose unit formulations, e.g. tablets and capsules. This study aimed at formulation of controlled-release pellets of doxazosin mesylate (DM), a widely used treatment for antihypertensive and benign prostatic hyperplasia. DM was loaded onto microcrystalline cellulose CELLETS pellets using hydroalcoholic solution and alcoholic suspension layering techniques to achieve a minimum drug load of 4 mg DM/g pellets. DM-layered CELLETS were coated by Aquacoat dispersion (ready-made ethylcellulose dispersion) using a coating pan technique as a simple and widely utilized technique in pharmaceutical industry. Controlled-release DM-layered pellets showed a release profile comparable to the controlled-release commercial product Cardura XL Tablet. Also, the mechanism of DM release from Aquacoat CELLETS was mathematically modeled and imaged by scanning electron microscopy to elucidate drug release mechanisms from the prepared pellet formulations. Accelerated stability studies of the prepared pellets were performed under stress conditions of 40 C, and 75 % RH for 3 months. In conclusion, preparation of controlledrelease DM-layered CELLETS is feasible using a simple and conventional coating pan technology.