http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Gurses, Iclal (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
The Effect of Abraxane on Cell Kinetic Parameters of HeLa Cells
Gurses, Nurcan,Topcul, Mehmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Abraxane (nab-paclitaxel) is a member of the group of nano chemotherapeutics. It is approved for metastatic breast cancer and non small cell lung cancer. Trials for several cancer types including gynecological cancers, head and neck, and prostatic cancer are being studied. In this study, the antiproliferative and apoptotic effect of abraxane was evaluated on HeLa cell line originated from human cervix carcinoma. Three different doses ($D_1$=10 nM, $D_2$=50 nM, $D_3$=100 nM) were administered to HeLa cells for 24, 48 and 72 h. The 50 nM dose of abraxane decreased DNA synthesis from 4.62-0.08%, mitosis from 3.36-1.89% and increased apoptosis from 10.6-30% at 72 h. Additionally, tripolar metaphase plates were seen in mitosis preparations. In this study, abraxane effected cell kinetic parameters significantly. This results are consistent with other studies in the literature.
-
Alparslan Esen,Gokhan Gurses,Sebnem Akkulah 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.6
Few cases of spontaneous bone regeneration after extensive resection of the jaw bone have been reported, but it is more common in young adults or children. In this case, we report spontaneous bone healing in a 73-year-old female patient. On radiological examination, necrotic regions were seen in the right mandible. She was diagnosed with medication-related osteonecrosis of the jaw due to previous bisphosphonate use. After segmental resection, stabilization achieved using a reconstruction plate. The periosteum was preserved during the procedure. Twelve months later, panoramic radiography was taken and bone formation was seen both horizontally and vertically around the plate. If the periosteum is preserved and stabilization is achieved after resection in benign lesions, the bone may regenerate spontaneously regardless of age. Therefore, instead of simultaneous autogenous bone ap-plication, such patients may be followed to determine whether spontaneous bone healing will occur. This should improve patient comfort and reduce surgical cost.
-
Tezcan, Seda,Ozgur, Didem,Ulger, Mahmut,Aslan, Gonul,Gurses, Iclal,Serin, Mehmet Sami,Giray, Burcu Gurer,Dilek, Saffet,Emekdas, Gurol Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Background: Infection with certain human papillomavirus (HPV) genotypes is the most important risk factor related with cervical cancer. The objective of the present study was to investigate the prevalence of HPV infection, the distribution of HPV genotypes and HPV E6/E7 oncogene mRNA expression in Turkish women with different cervical cytological findings in Mersin province, Southern Turkey. Materials and Methods: A total of 476 cytological samples belonging to women with normal and abnormal cervical Pap smears were enrolled in the study. For the detection and genotyping assay, a PCR/direct cycle sequencing approach was used. E6/E7 mRNA expression of HPV-16, 18, 31, 33, and 45 was determined by type-specific real-time NASBA assay (NucliSENS EasyQ$^{(R)}$HPV v1.1). Results: Of the 476 samples, 106 (22.3%) were found to be positive for HPV DNA by PCR. The presence of HPV was significantly more common (p<0.001) in HSIL (6/8, 75%) when compared with LSIL (6/14, 42.9%), ASC-US (22/74, 29.7%) and normal cytology (72/380, 18.9%). The most prevalent genotypes were, in descending order of frequency, HPV genotype 66 (22.6%), 16 (20.8%), 6 (14.2%), 31 (11.3%), 53 (5.7%), and 83 (4.7%). HPV E6/E7 oncogene mRNA positivity (12/476, 2.5%) was lower than DNA positivity (38/476, 7.9%). Conclusions: Our data present a wide distribution of HPV genotypes in the analyzed population. HPV genotypes 66, 16, 6, 31, 53 and 83 were the predominant types and most of them were potential carcinogenic types. Because of the differences between HPV E6/E7 mRNA and DNA positivity, further studies are required to test the role of mRNA testing in the triage of women with abnormal cervical cytology or follow up of HPV DNA positive and cytology negative. These epidemiological data will be important to determine the future impact of vaccination on HPV infected women in our region.
-
PRODUCTIVITY ESTIMATION AND EFFECTIVENESS OF THE EDUCATION PUBLIC SERVICE SECTOR
BAYARMAA Gursed 단국대학교 몽골연구소 2020 몽골지역연구 Vol.5 No.1
Based on the fact the productivity measurement methodologies can be considered as systems, organizations, employees and patients (Steiger, 2009), the general model of measuring the productivity of the Mongolian government has been developed at the organizations, sectoral and national levels by providing an opportunity to integrate results of the productivity. This model can be used at public administration and specific sectors. The next issue of the research methodology decides how to measure using which methods and which criteria, based on how you consider the definition of the productivity. Therefore, we use a definition that combines health and education productivity with the efficiency and quality issues. It shows that the productivity measurement indicates not only economic content but also the changes in the quality of social life. We have developed a methodology for measuring educational productivity at the national, sectoral and organizational levels. The productivity estimation model was developed in Excel Spreadsheet in accordance with the methodology and successfully tested. This proves that it is possible to measure productivity in the UB’s health and education sectors using the modern method. The recommendations include that the data collection and processing should be done not only for sectors but also for nationwide. Moreover, the results of the research explain that the outcome of the public policy is determined by the productivity measurement and the further policies can be established. Again, the most important part of the research is to show that the productivity of the sector is measured by the economic outputs and then the outputs are adjusted to quality indicators to measure the productivity.
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
