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- 저자 : Guolong Lin (검색결과 2 건)
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Wei, Youheng,Fu, Guolong,Hu, Hairong,Lin, Gang,Yang, Jingchun,Guo, Jinhu,Zhu, Qiquan,Yu, Long Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.5
Phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization. In the present work, we reported the isolation and characterization of mouse testis-specific serine/threonine kinase 5 (Tssk5), which contains four alternatively spliced variants including, Tssk5$\alpha$, Tssk5$\beta$, Tssk5$\gamma$ and Tssk5$\delta$. Moreover, the locus of Tssk5 is on chromosome 14qC3 and the four variants had a similar high expression in the testis and the heart; however, had a low expression in other tissues, except for Tssk5$\alpha$ which also had comparably high expression in the spleen. Each variant of Tssk5 expression began in the testis 16 days after birth. Aside from TSSK5$\alpha$, the other isoforms have an insertion of ten amino acid residues (RLTPSLSAAG) in region VIb (HRD domain) (His-Arg-Asp). Moreover, only TSSK5$\alpha$ exhibited kinase activity and consistently, a further Luciferase Reporter Assay demonstrated that TSSK5$\beta$, TSSK5$\gamma$ and TSSK5$\delta$ cannot be stimulated at the CREB/CRE responsive pathway in comparison to TSSK5$\alpha$. These findings suggest that TSSK5$\beta$, TSSK5$\gamma$, TSSK5$\delta$ may be pseudokinases due to the insertion, which may damage the structure responsible for active kinase activity. Pull-down assay experiments indicated that TSSK5$\beta$, TSSK5 $\gamma$ and TSSK5$\delta$ can directly interact with TSSK5$\alpha$. In summary, these four isoforms with similar expression patterns may be involved in spermatogenesis through a coordinative way in testis.
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A Scheduling Model of the Icebreaker Assistance Service in the Northern Sea Route
Yi Ding,Weiwen Zhou,Dongmin Xu,Guolong Lin 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.4
The melting of the sea ice in the Arctic area increases the possibility of exploiting the Northern Sea Route (NSR)by economic method. Compared to the traditional routes, navigating through the Northern Sea Route (NSR) will save much distance and time from Asia to Europe, but the ice condition along the NSR is a key obstacle to most vessels. To ensure the safety of the navigation, ice breaker assistance service becomes crucial. This paper introduces the procedure of icebreaker assistance service firstly, and then a static scheduling model is presented to illustrate icebreaker assistance service. Considering real operation, a dynamic model is proposed, and First Come First Serve (FCFS) principle is implemented into models. The experiment results show that this model is beneficial to control the average waiting time, while it may leads to wait too long for some vessels. And the average fuel cost of each trip remains stable even increasing service request.
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