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Yao, Lei,Ji, Guixiang,Gu, Aihua,Zhao, Peng,Liu, Ning Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Objective: Glutathione S-transferases (GSTs) are multifunctional enzymes that play a crucial role in the detoxification of both the endogenous products of oxidative stress and exogenous carcinogens. Recent studies investigating the association between genetic polymorphisms in GSTs and the risk of adult brain tumors have reported conflicting results. The rationale of this pooled analysis was to determine whether the presence of a GST variant increases adult glioma susceptibility by combining data from multiple studies. Methods: In our meta-analysis, 12 studies were identified by a search of the MEDLINE, HIGHWIRE, SCIENCEDIRECT and EMBASE databases. Of those 12, 11 evaluated GSTM1, nine evaluated GSTT1 and seven evaluated GSTP1 Ile105Val. Between-study heterogeneity was assessed using ${\chi}^2$-based Q statistic and the $I^2$ statistic. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to estimate the association between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of adult gliomas. Results: The quantitative synthesis showed no significant evidence to indicate an association exists between the presence of a GSTM1, GSTT1 or GSTP1 Ile105Val haplotype polymorphism and the risk of adult gliomas (OR, 1.008, 1.246, 1.061 respectively; 95% CI, 0.901-1.129, 0.963-1.611, 0.653-1.724 respectively). Conclusions: Overall, this study did not suggest any strong relationship between GST variants or related enzyme polymorphisms and an increased risk of adult gliomas. Some caveats include absence of specific raw information on ethnic groups or smoking history on glioma cases in published articles; therefore, well-designed studies with a clear stratified analysis on potential confounding factors are needed to confirm these results.
Qingping Luo,Chonghua Pei,Guixiang Liu,Yongjun Ma,Zhaoqian Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.3
Cyclotrimethylenetrinitramine (RDX) is an energetic material (EM) from the class of cyclic nitroamine explosive widely used in military applications because of its excellent integral properties. Using bacterial cellulose (BC) gelatin with a three-dimensional network as a matrix, N,Ndimethyllformamide (DMF) as the solvent of RDX, the RDX nanostructured explosives were prepared through the solvent/nonsolvent method. It was found that the solvent had a great impact on the crystallization of RDX in the solution and the RDX content in the nanostructured explosive. The RDX particles in the nanostructured explosives smoothly coated to the nanofibers of BC gelatin network at high RDX concentrations, and the granularity distributions of RDX in the nanostructured explosives were very uniform in the range of 30–50 nm. The average contents of the RDX in the nanostructured explosives are greater than 83 wt.% when the RDX concentrations of the soaked solutions are greater than 0.20 g/mL. The average content is approximately 91 wt.% when the RDX concentration is 0.30 g/mL. The decomposition temperatures of the RDX nanostructured explosives were found to decrease approximately to 20 C and their mechanical sensitivities decreased greatly compared to that of raw micro-size RDX. It opens a useful way to prepare nanostructured explosives with high energy and low mechanical sensitivity.