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Modeling of reinforced concrete structural members for engineering purposes
Jacky Mazars,Stéphane Grange 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.5
When approached using nonlinear finite element (FE) techniques, structural analyses generate, for real RC structures, large complex numerical problems. Damage is a major part of concrete behavior, and the discretization technique is critical to limiting the size of the problem. Based on previous work, the μ damage model has been designed to activate the various damage effects correlated with monotonic and cyclic loading, including unilateral effects. Assumptions are formulated to simplify constitutive relationships while still allowing for a correct description of the main nonlinear effects. After presenting classical 2D finite element applications on structural elements, an enhanced simplified FE description including a damage description and based on the use of multi-fiber beam elements is provided. Improvements to this description are introduced both to prevent dependency on mesh size as damage evolves and to take into account specific phenomena (permanent strains and damping, steelconcrete debonding). Applications on RC structures subjected to cyclic loads are discussed, and results lead to justifying the various concepts and assumptions explained.
Extracellular vesicles in onco-nephrology
Chiara Gai,Margherita A. C. Pomatto,Cristina Grange,Maria Chiara Deregibus,Giovanni Camussi 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Extracellular vesicles (EVs) are important mediators of intercellular communication in cancer and in normal tissues. EVs transfer biologically active molecules from the cell of origin to recipient cells. This review summarizes the studies on EVs derived from renal cell carcinoma and from a subpopulation of CD105-positive renal cancer stem cells. While EVs from renal cell carcinoma show mild biological activity, EVs from renal cancer stem cells enhance tumor angiogenesis and metastasis formation. The effect is probably due to the transfer of proangiogenic RNA cargo to endothelial cells, which acquire an activated angiogenic phenotype. In vivo, treatment with EVs favors the formation of a premetastatic niche in the lungs. Moreover, EVs derived from renal cancer stem cells modify gene expression in mesenchymal stromal cells, enhancing the expression of genes involved in matrix remodeling, cell migration, and tumor growth. Mesenchymal stromal cells preconditioned with tumor EVs and then coinjected in vivo with renal cancer cells support tumor growth and vessel formation. Finally, tumor EVs promote tumor immune escape by inhibiting the differentiation process of dendritic cells and the activation of T cells. Thus, tumor-derived EVs act on the microenvironment favoring tumor aggressiveness, may contribute to angiogenesis through both direct and indirect mechanisms and are involved in tumor immune escape.
Dark matter search in nucleon, pion, and electron channels from a proton beam dump with MiniBooNE
Aguilar-Arevalo, A. A.,Backfish, M.,Bashyal, A.,Batell, B.,Brown, B. C.,Carr, R.,Chatterjee, A.,Cooper, R. L.,deNiverville, P.,Dharmapalan, R.,Djurcic, Z.,Ford, R.,Garcia, F. G.,Garvey, G. T.,Grange, American Physical Society 2018 Physical Review D Vol.98 No.11
Dark Matter Search in a Proton Beam Dump with MiniBooNE
Aguilar-Arevalo, A. A.,Backfish, M.,Bashyal, A.,Batell, B.,Brown, B. C.,Carr, R.,Chatterjee, A.,Cooper, R. L.,deNiverville, P.,Dharmapalan, R.,Djurcic, Z.,Ford, R.,Garcia, F. G.,Garvey, G. T.,Grange, American Physical Society 2017 Physical Review Letters Vol.118 No.22
이경구(Gyeong-Gu Lee),하동경(Dong-Gyeong Ha),유강주(Grang-Ju Yu),신옥근(Ok-Keun Shin) 한국정보과학회 영남지부 2007 한국정보과학회 영남지부 학술발표논문집 Vol.1 No.1
블루투스 기술에 기반한 무선헤드폰 장치는 음악을 전송하는 송신장치가 근거리에 위치한 단일의 수신측 무선헤드폰 장치에 음악을 전송하는 단일링크 구조로 구성되어 있다. 음악 재생 서비스를 제공하기 위해서는 데이터 전송의 동시성과 연속성이 보장되어야 끊기지 않고 신뢰성이 보장된 서비스를 제공할 수 있다. 따라서 장치들 간의 링크구조가 1:1 단일 구조의 한계성을 가지게 된다. 본 논문에서는 단일의 송신장치가 두 개의 수신장치에 각각의 개별 링크를 설정하여 동일한 음악을 동시에 전송하기 위한 시스템의 구성 방법을 제안하였다. 제안한 방법에서는 시스템의 전송효율을 높이기 위하여 멀티 스레드 처리 기법을 사용하였으며, 블루투스스택 클래스를 구현하였다. 제안한 이중링크 음악전송 시스템의 전송효율을 분석하기 위한 데이터 전송 실험을 통하여 다중링크 음악 전송의 가능성을 확인하였다.