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      • KCI등재

        On the Laplace Transform and the Generalized Weyl Fractional Integral Operator Involving the H-function

        S. P. Goyal,R. Mukherjee,R. Jain 경북대학교 자연과학대학 수학과 2004 Kyungpook mathematical journal Vol.44 No.4

        In the present paper, we establish a general theorem exhibiting a relationship existing between the Laplace transform and the generalized Weyl fractional integral operator (FIO) of related functions. This theorem is very general in nature and involves a multidimensional series with essentially arbitrary sequence of complex numbers. By suitably assigning different values to these sequences, one can easily evaluate the generalized Weyl fractional integral operator of special functions of several variables. References of known results which follow as special cases of our theorem are also cited. We have obtained here as applications of the theorem, the generalized Weyl fractional integral of(Srivastava-Daoust) generalized Lauricella function which gives a number of results involving special functions of one or more variables merely by specializing the parameters. The results recently obtained by R. Jain and M. A. Pathan and S. P. Goyal and Ritu Goyal,etc. follow as special cases of our main findings.

      • Pharmacological classification of herbal anti-asthmatics

        Goyal, Bhoomika R,Agrawal, Babita B,Goyal, Ramesh K,Mehta, Anita A Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.1

        Bronchial asthma is a major public health problem worldwide and the morbidity and mortality of asthma have increased in last few decades. There is high prevalence of usage of alternative traditional system of medicines for the treatment of asthma. Large numbers of medicinal plant preparations have been reported to possess anti-asthmatic effects. Plant cells are now considered to be the chemical factories synthesizing a large variety of chemical compounds. Further, Ayurvedic system of medicine has an elaborate description of asthma from the earliest times describing it as 'Shwasa' meaning disease pertaining to breathing. This review classifies the antiasthmatics herbs based on the possible mechanism of action reported. Thus, these plants can be used to obtain a polyherbal formulation which contains various herbs acting at particular sites of the pathophysiological cascade of asthma for prophylaxis as well as for the treatment of asthma.

      • Investigation into the mechanism of anti-asthmatic action of Lepidium sativum

        Goyal, BR,Goyal, RK,Mehta, Anita A Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.3

        We have studied the possible mechanism of anti-asthmatic action of ethanolic extracts of dried seeds of Lepidium sativum (EXLS, 400 mg/kg) using various experimental models. EXLS produced an increase in the Pre-Convulsion Dyspnoea time induced by histamine and acetylcholine aerosol, a significant reduction in the elevated leucocyte counts in the Broncho-Alveolar Lavage fluid of sensitized guinea-pigs and reduction in the paw edema volume as compared to the control rats. Treatment with EXLS also produced decrease in the elevated histamine release from the sensitized guinea-pig lungs. The anti-asthmatic anti-inflammatory responses of EXLS was supported by improvement in microscopic changes like infiltration of inflammatory cells, submucosal edema, epithelial desquamation and reduced lumen size of the bronchi. The $pD_2$ values of histamine in tracheal chain and taenia-coli were significantly greater and that in lung strip was lower in the sensitized animals as compared to control. Treatment of sensitized guinea pigs with EXLS significantly decreased $pD_2$ values of histamine in all three preparations. Our data suggest the prevention of hyper-responsiveness in bronchial smooth muscles and inhibition of the immediate hypersensitive reaction, histamine release in the lungs and the infiltration of various inflammatory cells as the possible mechanisms of anti-asthmatic activity of EXLS.

      • KCI등재

        Efficacy of interventional treatment strategies for managing patients with cervicogenic headache: a systematic review

        Goyal Sonal,Kumar Ajit,Mishra Priyanka,Goyal Divakar 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.1

        Cervicogenic headache (CeH) is caused by the disorder of the cervical spine and its anatomical structures. Patients who fail to respond to conservative therapies can undergo interventional treatment. The purpose of this review is to describe the various interventions and compare their relative efficacies. Although a few reviews have been published focusing on individual interventions, reviewing studies on other available treatments and establishing the most efficacious approach is still necessary. We performed a systematic review of studies available on the various interventions for CeH. The PubMed, Embase, and Cochrane databases were searched for literature published between January 2001 and March 2021. Based on the inclusion criteria, 23 articles were included. Two reviewers independently extracted the data from the studies and summarized them in a table. Eleven of twenty-three studies evaluated the effect of radiofrequency ablation (RFA), 5 evaluated occipital nerve blocks, 2 each for facet joint injections and deep cervical plexus blocks, and 1 study each evaluated atlantoaxial (AA) joint injections, cervical epidural injection, and cryoneurolysis. Most of the studies reported pain reduction except 2 studies on RFA. In conclusion, based on the available literature, occipital nerve blocks, cervical facet joint injection, AA joint injection, deep cervical plexus block, cervical epidural injection may be reasonable options in refractory cases of CeH. RFA was found to have favorable long-term outcomes, while better safety has been reported with pulsed therapy. However, our review revealed only limited evidence, and more randomized controlled trials are needed to provide more conclusive evidence.

      • KCI등재후보

        Investigation into the mechanism of anti–asthmatic action of Lepidium sativum

        BR Goyal,RK Goyal,Anita A Mehta 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3

        We have studied the possible mechanism of anti-asthmatic action of ethanolic extracts of dried seeds of Lepidium sativum (EXLS, 400 mg/kg) using various experimental models. EXLS produced an increase in the Pre-Convulsion Dyspnoea time induced by histamine and acetylcholine aerosol, a significant reduction in the elevated leucocyte counts in the Broncho- Alveolar Lavage fluid of sensitized guinea-pigs and reduction in the paw edema volume as compared to the control rats. Treatment with EXLS also produced decrease in the elevated histamine release from the sensitized guinea-pig lungs. The anti-asthmatic anti-inflammatory responses of EXLS was supported by improvement in microscopic changes like infiltration of inflammatory cells, submucosal edema, epithelial desquamation and reduced lumen size of the bronchi. The pD2 values of histamine in tracheal chain and taenia-coli were significantly greater and that in lung strip was lower in the sensitized animals as compared to control. Treatment of sensitized guinea pigs with EXLS significantly decreased pD2 values of histamine in all three preparations. Our data suggest the prevention of hyper-responsiveness in bronchial smooth muscles and inhibition of the immediate hypersensitive reaction, histamine release in the lungs and the infiltration of various inflammatory cells as the possible mechanisms of anti-asthmatic activity of EXLS. We have studied the possible mechanism of anti-asthmatic action of ethanolic extracts of dried seeds of Lepidium sativum (EXLS, 400 mg/kg) using various experimental models. EXLS produced an increase in the Pre-Convulsion Dyspnoea time induced by histamine and acetylcholine aerosol, a significant reduction in the elevated leucocyte counts in the Broncho- Alveolar Lavage fluid of sensitized guinea-pigs and reduction in the paw edema volume as compared to the control rats. Treatment with EXLS also produced decrease in the elevated histamine release from the sensitized guinea-pig lungs. The anti-asthmatic anti-inflammatory responses of EXLS was supported by improvement in microscopic changes like infiltration of inflammatory cells, submucosal edema, epithelial desquamation and reduced lumen size of the bronchi. The pD2 values of histamine in tracheal chain and taenia-coli were significantly greater and that in lung strip was lower in the sensitized animals as compared to control. Treatment of sensitized guinea pigs with EXLS significantly decreased pD2 values of histamine in all three preparations. Our data suggest the prevention of hyper-responsiveness in bronchial smooth muscles and inhibition of the immediate hypersensitive reaction, histamine release in the lungs and the infiltration of various inflammatory cells as the possible mechanisms of anti-asthmatic activity of EXLS.

      • KCI등재후보

        Pharmacological classification of herbal anti-asthmatics

        Bhoomika R Goyal,Babita B Agrawal,,Ramesh K Goyal,Anita A Mehta 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.1

        Bronchial asthma is a major public health problem worldwide and the morbidity and mortality of asthma have increased in last few decades. There is high prevalence of usage of alternative traditional system of medicines for the treatment of asthma. Large numbers of medicinal plant preparations have been reported to possess anti-asthmatic effects. Plant cells are now considered to be the chemical factories synthesizing a large variety of chemical compounds. Further, Ayurvedic system of medicine has an elaborate description of asthma from the earliest times describing it as ‘Shwasa’ meaning disease pertaining to breathing. This review classifies the antiasthmatics herbs based on the possible mechanism of action reported. Thus, these plants can be used to obtain a polyherbal formulation which contains various herbs acting at particular sites of the pathophysiological cascade of asthma for prophylaxis as well as for the treatment of asthma.

      • SCOPUSKCI등재
      • SCIESCOPUSKCI등재

        Adsorption of p-Nitrophenol by Surface Modified Carbons from Aqueous Solution

        Goyal, Meenakshi Korean Carbon Society 2004 Carbon Letters Vol.5 No.2

        Adsorption isotherms of p-nitrophenol from its aqueous solutions on two samples of activated carbon fibres and two samples of granulated activated carbons have been determined in the concentration range 40~800 mg/L (ppm). The surface of these carbons was modified by oxidation with nitric acid and oxygen gas, and by degassing the carbon surface under vacuum at temperatures of $400^{\circ}C$, $650^{\circ}C$ and $950^{\circ}C$. The oxidation of carbon enhances the amount of carbon-oxygen surface groups, while degassing decreases the amount of these surface groups. The adsorption of p-nitrophenol does not depend upon the surface area alone but appears to be influenced by the presence of oxygen groups on the carbon surface. The adsorption decreases on oxidation while the degassing of the carbon surface enhances the adsorption. The decrease in adsorption depends upon the strength of the oxidative treatment being much larger in case of the oxidation with nitric acid, while the decrease in adsorption on degassing depends upon the temperature of degassing. The results show that while the presence of acidic surface groups which are evolved as $CO_2$ on degassing suppress the adsorption of p-nitrophenol, the presence of non acidic surface groups which are evolved as CO on degassing tend to enhance the adsorption. Suitable mechanisms compatible with the results have been presented.

      • SCISCIESCOPUS

        Interfacial adsorption behavior of quaternary phosphonium based ionic liquids on metal-electrolyte interface: Electrochemical, surface characterization and computational approaches

        Goyal, Madhusudan,Kumar, Sudershan,ChandrabhanVerma, Sudershan,Bahadur, Indra,Ebenso, Eno E.,Lgaz, Hassane,Chung, Ill-Min Elsevier 2020 Journal of Molecular Liquids Vol.298 No.-

        <P><B>Abstract</B></P> <P>In present study two quaternary phosphonium salts namely (1-NapthylMethyl)-triphenylphosphonium Chloride (1-NpMe-TPC) and (4-Methoxybenzyl)-triphenylphosphonium Bromide (4-MeOBz-TPB) are reported as inhibitors for mild steel (MS) corrosion in 0.5MH<SUB>2</SUB>SO<SUB>4</SUB> using various electrochemical, theoretical and surface morphological techniques. Inhibitors 1-NpMe-TPC and 4-MeOBz-TPB were prepared by diluting the solution of concentration 10<SUP>−2</SUP> to 10<SUP>−5</SUP> M and results are showed maximum efficiencies of 99.72% and 97.76%, respectively at 10<SUP>−3</SUP> M concentration (298K). Polarization measurements revealed that both 1-NpMe-TPC and 4-MeOBz-TPB acted as mixed corrosion inhibitors. EIS study revealed that 1-NpMe-TPC and 4-MeOBz-TPB adsorbed at the mild steel/0.5M H<SUB>2</SUB>SO<SUB>4</SUB> interfaces and enhanced the magnitude of charge transfer resistances. Adsorption of the 1-NpMe-TPC and 4-MeOBz-TPB at the metallic surface was further supported by SEM and AFM studies. Several thermodynamic parameters ( Δ G a d s 0 , Δ H a d s 0 and Δ S a d s 0 ), Semi-empirical AM1 and MD parameters were derived in order to <SUP>describe</SUP> the adsorption behavior of 1-NpMe-TPC and 4-MeOBz-TPB on metallic surface. The reasonable consistence was found between experimental and theoretical results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Quaternary phosphonium ionic salts are reported as corrosion inhibitors. </LI> <LI> Electrochemical, theoretical and surface morphological techniques were used. </LI> <LI> The results were supported by SEM, AFM and QC Calculations. </LI> </UL> </P>

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