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Govindaraj Saravanan,Veerachamy Alagarsamy,Pandurangan Dineshkumar 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
A series of novel isoxazole coupled quinazolin-4(3H)-one derivatives were synthesized and characterizedby FT-IR, 1H NMR, mass spectroscopy and bases of elementalanalysis with the aim of developing potent analgesic,anti-inflammatory and antimicrobial agents. Tailflicktechnique, carrageenan-induced foot paw edema testand agar streak dilution test were performed for screeninganalgesic, anti-inflammatory and in vitro antimicrobialactivity respectively. Moreover all compounds wereexamined for its ulcerogenicity. Results revealed that entireseries of compounds exhibited mild to good analgesic, antiinflammatoryand antimicrobial activity with low to moderateulcer index. The relationship between the functionalgroup variation and the biological activity of the evaluatedcompounds was discussed. Out of various synthesizedcompounds, 2-methyl-3-(4-(5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)phenyl)quinazolin-4(3H)-one 5e was foundto be the most active compound.