Molecular Analyses of the Metallothionein Gene Family in Rice (Oryza sativa L.)

( Gong Ke Zhou ),( Yu Feng Xu ),( Ji Li ),( Ling Yan Yang ),( Jin Yuan Liu ) 생화학분자생물학회 2006 BMB Reports Vol.39 No.5

Investigation of the behavior of a crack between two half-planes of functionally graded materials by using the Schmidt method

Zhou, Zhen-Gong,Wang, Biao,Wu, Lin-Zhi Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.4

In this paper, the behavior of a crack between two half-planes of functionally graded materials subjected to arbitrary tractions is resolved using a somewhat different approach, named the Schmidt method. To make the analysis tractable, it is assumed that the Poisson's ratios of the mediums are constants and the shear modulus vary exponentially with coordinate parallel to the crack. By use of the Fourier transform, the problem can be solved with the help of two pairs of dual integral equations in which the unknown variables are the jumps of the displacements across the crack surfaces. To solve the dual integral equations, the jumps of the displacements across the crack surfaces are expanded in a series of Jacobi polynomials. This process is quite different from those adopted in previous works. Numerical examples are provided to show the effect of the crack length and the parameters describing the functionally graded materials upon the stress intensity factor of the crack. It can be shown that the results of the present paper are the same as ones of the same problem that was solved by the singular integral equation method. As a special case, when the material properties are not continuous through the crack line, an approximate solution of the interface crack problem is also given under the assumption that the effect of the crack surface interference very near the crack tips is negligible. It is found that the stress singularities of the present interface crack solution are the same as ones of the ordinary crack in homogenous materials.

Transcriptional regulation of Glis2 in hepatic fibrosis

Gong Huan-Yu,Zhou Peng-Cheng,Zhang Hao-Ye,Chen Li-Min,Zhou Yang-Mei,Liu Zhen-Guo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

The role of Gli-similar 2 (Glis2) in hepatic fibrosis (HF) is controversial. In this study, we focused on the functional and molecular mechanisms involved in the Glis2-mediated activation of hepatic stellate cells (HSCs)—a milestone event leading to HF. The expression levels of Glis2 mRNA and protein were significantly decreased in the liver tissues of patients with severe HF and in mouse fibrotic liver tissues as well as HSCs activated by TGFβ1. Functional studies indicated that upregulated Glis2 significantly inhibited HSC activation and alleviated BDL-induced HF in mice. Downregulation of Glis2 was found to correlate significantly with DNA methylation of the Glis2 promoter mediated by methyltransferase 1 (DNMT1), which restricted the binding of hepatic nuclear factor 1-α (HNF1-α), a liver-specific transcription factor, to Glis2 promoters. In addition, the enrichment of DNMT1 in the Glis2 promoter region was mediated by metastasis-associated lung adenocarcinoma transcriptor-1 (MALAT1) lncRNA, leading to transcriptional silencing of Glis2 and activation of HSCs. In conclusion, our findings reveal that the upregulation of Glis2 can maintain the resting state of HSCs. The decreased expression of Glis2 under pathological conditions may lead to the occurrence and development of HF with the expression silencing of DNA methylation mediated by MALAT1 and DNMT1.

The nonlocal theory solution for two collinear cracks in functionally graded materials subjected to the harmonic elastic anti-plane shear waves

Zhou, Zhen-Gong,Wang, Biao Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.23 No.1

In this paper, the scattering of harmonic elastic anti-plane shear waves by two collinear cracks in functionally graded materials is investigated by means of nonlocal theory. The traditional concepts of the non-local theory are extended to solve the fracture problem of functionally graded materials. To overcome the mathematical difficulties, a one-dimensional non-local kernel is used instead of a two-dimensional one for the anti-plane dynamic problem to obtain the stress field near the crack tips. To make the analysis tractable, it is assumed that the shear modulus and the material density vary exponentially with coordinate vertical to the crack. By use of the Fourier transform, the problem can be solved with the help of a pair of triple integral equations, in which the unknown variable is the displacement on the crack surfaces. To solve the triple integral equations, the displacement on the crack surfaces is expanded in a series of Jacobi polynomials. Unlike the classical elasticity solutions, it is found that no stress singularities are present at crack tips.

Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery

Gong, Jian-Ping,Yang, Liu,Huang, Xin-En,Sun, Bei-Cheng,Zhou, Jian-Nong,Yu, Dong-Sheng,Zhou, Xin,Li, Dong-Zheng,Guan, Xin,Wang, Dong-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Purpose: Anastomotic leakage (AL) is associated with high morbidity and mortality, high reoperation rates, and increased hospital length of stay. Here we investigated the risk factors for AL after anterior resection for rectal cancer with a double stapling technique. Patients and Methods: Data for 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2003 to 2007 were prospectively collected. All patients experienced a total mesorectal excision (TME) operation. Clinical AL was defined as the presence of leakage signs and confirmed by diagnostic work-up according to ICD-9 codes 997.4, 567.22 (abdominopelvic abscess), and 569.81 (fistula of the intestine). Univariate and logistic regression analyses of 20 variables were undertaken to determine risk factors for AL. Survival was analysed using the Cox regression method. Results: AL was noted in 35 (7.6%) of 460 patients with rectal cancer. :Median age of the patients was 65 (50-74) and 161 (35%) were male. The diagnosis of AL was made between the 6th and 12th postoperative day (POD; mean 8th POD). After univariate and multivariate analysis, age (p=0.004), gender (p=0.007), tumor site (p<0.001), preoperative body mass index (EMI) (p<0.001), the reduction of TSGF on 5th POD less than 10U/ml (p=0.044) and the pH value of pelvic dranage less than or equal to 6.978 on 3rd POD (p<0.001) were selected as 6 independent risk factors for AL. It was shown that significant differences in survival of the patients were AL-related (p<0.001), high ASA score related (p=0.036), high-level EMI related (p=0.007) and advanced TNM stage related <p<0.001). Conclusions: AL after anterior resection for rectal carcinoma is related to advanced age, low tumor site, male sex, high preoperative EMI, low pH value of pelvic drainage on POD 3 and a significant reduction of TSGF on POD 5. In addition to their high risk of immediate postoperative morbidity and mortality, AL, worse physical status, severe obesity and advanced TNM stage have similarly negative impact on survival.

ANOXIC TREATMENT OF LOW - STRENGTH WASTEWATER BY IMMOBILIZED SLUDGE

( Gong Ming Zhou,Herbert H . P . Fang,Kwai Leung Lo ) 한국물환경학회 1997 제6차 국제수질보전학회 아시아 태평양지역 학술회의 Vol.1 No.-

Two collinear Mode-I cracks in piezoelectric/piezomagnetic materials

Zhou, Zhen-Gong,Wang, Jia-Zhi,Wu, Lin-Zhi Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.29 No.1

In this paper, the behavior of two collinear Mode-I cracks in piezoelectric/piezomagnetic materials subjected to a uniform tension loading was investigated by the generalized Almansi's theorem. Through the Fourier transform, the problem can be solved with the help of two pairs of triple integral equations, in which the unknown variables were the jumps of displacements across the crack surfaces. To solve the triple integral equations, the jumps of displacements across the crack surfaces were directly expanded as a series of Jacobi polynomials to obtain the relations among the electric displacement intensity factors, the magnetic flux intensity factors and the stress intensity factors at the crack tips. The interaction of two collinear cracks was also discussed in the present paper.

VALVE MOTION CHARACTERISTICS AND APPLICATION ON ENGINE BASED ON A NEW VARIABLE VALVE ACTUATION SYSTEM

You Zhou,Weihong Zhou,Fangxi Xie,Yu Liu,Xiaoping Li,Xun Gong 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.1

A new mechanical-hydraulic variable valve actuation (VVA) system was developed and a thin-wall orifice velocity control system were analyzed. Meanwhile, influence of speed, needle valve overflow area, oil temperature and oil supply pressure on valve motion characteristics were explored, as well as the VVA system have been applied on a single-cylinder engine preliminary. By the VVA system, valve lifts can be adjusted from maximum of 8.7 mm to fully closing. Valve seating velocity decreased with orifice diameter reducing. Seating velocity can be maintained below 0.5 m/s with 0.8 mm diameter of thin-wall orifice and 3 mm check valve moving distance. Besides that, velocity control system also can help improve the coefficient of cyclic variation of maximum valve lift. Except for the needle valve closing state, valve lift decreased with oil temperature increasing and operating speed reducing under the same needle valve state. Oil supply pressure hardly had no influence on valve lifts, but delayed valve opening timing with pressure decreasing. Thin-wall orifice seating velocity control system was not sensitive to variable oil temperature and supply pressure. Compared with conventional engine, adjusting intake valve by VVA system under un-throttle internal EGR strategy, can improve BSFC and NOX emissions significantly about 13.8 % and 19.8 % on 6 bar IMEP.

Two collinear Mode-I cracks in piezoelectric/piezomagnetic materials

Zhen-Gong Zhou,Jia-Zhi Wang,Lin-Zhi Wu 국제구조공학회 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.29 No.1

In this paper, the behavior of two collinear Mode-I cracks in piezoelectric/piezomagnetic materials subjected to a uniform tension loading was investigated by the generalized Almansi’s theorem. Through the Fourier transform, the problem can be solved with the help of two pairs of triple integral equations, in which the unknown variables were the jumps of displacements across the crack surfaces. To solve the triple integral equations, the jumps of displacements across the crack surfaces were directly expanded as a series of Jacobi polynomials to obtain the relations among the electric displacement intensity factors, the magnetic flux intensity factors and the stress intensity factors at the crack tips. The interaction of two collinear cracks was also discussed in the present paper.

Investigation of the behavior of a crack between two half-planes of functionally graded materials by using the Schmidt method

Zhen-Gong Zhou,Biao Wang,Lin-Zhi Wu 국제구조공학회 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.4

In this paper, the behavior of a crack between two half-planes of functionally graded materials subjected to arbitrary tractions is resolved using a somewhat different approach, named the Schmidt method. To make the analysis tractable, it is assumed that the Poisson’s ratios of the mediums are constants and the shear modulus vary exponentially with coordinate parallel to the crack. By use of the Fourier transform, the problem can be solved with the help of two pairs of dual integral equations in which the unknown variables are the jumps of the displacements across the crack surfaces. To solve the dual integral equations, the jumps of the displacements across the crack surfaces are expanded in a series of Jacobi polynomials. This process is quite different from those adopted in previous works. Numerical examples are provided to show the effect of the crack length and the parameters describing the functionally graded materials upon the stress intensity factor of the crack. It can be shown that the results of the present paper are the same as ones of the same problem that was solved by the singular integral equation method. As a special case, when the material properties are not continuous through the crack line, an approximate solution of the interface crack problem is also given under the assumption that the effect of the crack surface interference very near the crack tips is negligible. It is found that the stress singularities of the present interface crack solution are the same as ones of the ordinary crack in homogenous materials.