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Oxidative Stress Is Decreased in Off-pump Versus On-pump Coronary Artery Surgery
Gonenc, Aymelek,Haclsevki, Aysun,Bakkaloglu, Beyhan,Soyaglr, Aylin,Torun, Meral,Karagoz, Haldun,Simsek, Bolkan Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.4
Oxidative stress occurs in patients undergoing coronary artery bypass operation. The aim of this study was to investigate the difference in oxidative stress in off-pump versus on-pump coronary artery bypass surgery. In the present study, in serial blood samples, plasma malondialdehyde (MDA) as index of lipid peroxidation, red blood cells glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured to compare the extent of oxidative stress in 30 patients undergoing OPCAB (off-pump coronary artery bypass grafting), 12 patients undergoing CABG (on-pump coronary artery bypass grafting) and 18 healthy controls. In CABG group, MDA levels increased significantly from $2.87{\pm}0.62\;nmol/mL$ before anesthesia and $2.87{\pm}0.65\;nmol/mL$ after anesthesia to $3.05{\pm}0.66\;nmol/mL$ after ischemia (p < 0.05). Similarly, SOD levels also elevated significantly from $661.58{\pm}78.70\;U/g$ Hb before anesthesia and $659.42{\pm}81.21\;U/g$ Hb anesthesia induction to $678.08{\pm}75.80\;U/g$ Hb after ischemia (p < 0.01, p < 0.01, respectively). In OPCAB group, only SOD levels increased from $581.73{\pm}86.24\;U/g$ Hb anesthesia induction to $590.90{\pm}88.90\;U/g$ Hb after reperfusion (p < 0.05). Glutathione peroxidase levels were not changed according to blood collection times in both of CABG group or OPCAB group (p > 0.05). Our results show that only mild signs of oxidative stress is found after reperfusion in OPCAB operation compared with CABG operation. Further studies are needed in order to confirm this hypothesis.
He Zhang,Berk Gonenc,Iulian Iordachita 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
Retinal vein occlusion is one of the most common retinovascular diseases. Retinal vein cannulation is a potentially effective treatment method for this condition that currently lies, however, at the limits of human capabilities. In this work, the aim is to use robotic systems and advanced instrumentation to alleviate these challenges, and assist the procedure via a humanrobot collaborative mode based on our earlier work on the Steady-Hand Eye Robot and force-sensing instruments. An admittance control method is employed to stabilize the cannula relative to the vein and maintain it inside the lumen during the injection process. A pre-stress strategy is used to prevent the tip of microneedle from getting out of vein in in prolonged infusions, and the performance is verified through simulations.
The Process of Branding a City-Antakya as a Model-
( Cemal Yukselen ),( Emel Gonenc Guler ),( R. Aysen Wolff ) 세계문화관광학회 2010 International Journal of Culture and tourism Resea Vol.3 No.1
In studies about the branding of destinations, one finds the need to involve all the local and international stakeholders in the process of SWOT analysis and prepare a unique action plan. The Brand Destination Project of the Ministry of Culture and Tourism in Turkey is interested in making various famous cities culturally attractive to tourists. They expect economic and social development as they carry their historical values into the future. Antioch, the ancient name of Antakya, is one of the destinations targeted for branding in this project. Antioch was once the third largest trade and tourism center in the Roman Empire. It was also one of the first places to become a center for Christianity, drawing many pilgrims. It was a melting pot for many ancient civilizations in Anatolia. The purpose of this paper is to brand Antioch as a place where people have been living in the spirit of tolerance and brotherhood for many centuries against the backdrop of different religions and ethnicities. Furthermore, this paper includes suggestions for branding processes, responsibilities of stakeholders, and conclusions which may be realized by SWOT analysis and other exploratory research.
Design of an MRI-Compatible Modularized Needle Driver for In-Bore MRI-Guided Prostate Interventions
Ki-Young Kim,Meng Li,Berk Gonenc,Weijian Shang,Sohrab Eslami,Iulian Iordachita 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
Magnetic resonance imaging (MRI) provides high-quality three dimensional visualization of prostate tissue, therefore MRI-guided prostate biopsy has been introduced to enhance cancer detection and treatment. However, closed-bore MRI has not been widely adopted for prostate interventions due to physical limitation of in-bore access and workspace. In this paper, we propose an MRI-compatible robotic manipulator which is able to perform both prostate biopsy and brachytherapy intervention in a closed-bore MRI scanner. The proposed manipulator mainly consists of a base robot and a needle driver. The needle driver can operate a conventional biopsy gun. The needle driver is draped separately from the base robot for sterilization, thus it can be detached from the base robot for needle replacing through a quick-release mechanism. Mechanical design and kinematic analysis of the robotic manipulator are delineated according to the constraints of the MRI environment and the clinical workflow.
Intramural hematomas of the gastrointestinal system
Osman Kones,Ahmet Cem Dural,Murat Gonenc,Mehmet Karabulut,Cevher Akarsu,Ilhan Gok,M. Abdussamet Bozkurt,Mehmet Ilhan,Halil Alıs 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.2
Purpose: Although spontaneous intramural hematomas of the gastrointestinal tract are very rare, they may be observed with the use of oral anticoagulant, though less frequently in cases of hematological malignancy and other bleeding disorders. Cases diagnosed as spontaneous intramural hematoma have been assessed in our clinic. Methods: The cases, which were diagnosed as spontaneous intramural hematoma in the gastrointestinal tract (SIHGT) following anamnesis, physical examination, biochemical, radiological and endoscopic findings from July 2008 to July 2012, have been assessed retrospectively. Results: Seven out of 13 cases were women and the mean age was 65.1 years (34 to 82 years). The most frequent complaint on admission was abdominal pain. The most frequent location of SIHGT was the ileum (n = 8). Oral anticoagulant use was the most common cause of etiology (n = 12). In 10 cases, International normalized ratio values were higher than treatment range (2 to 3, where mechanical valve replacement was 2.5 to 3.5) and mean value was 7.6 (1.70 to 23.13). While 12 cases were discharged without problems with medical treatment, one case with acute myeloid leukemia died in the intensive care unit following cerebrovascular attack. Conclusion: Spontaneus bleeding and hematomas that may arise in connection with bleeding diathesis may be fatal in cases with long-term oral anticoagulant treatment and insufficient follow-up. In management of these cases, it may be necessary to arrange conservative follow up and/or initialize low molecular weight heparin, and administer vitamin K as well as replace blood products and coagulation factors when indicated.