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      • Transition metal-catalyzed tandem carbon-oxygen and carbon-carbon bond forming reactions of alkynes in (1) the addition-cyclization of carboxylic acids with 1,6-diynes and in (2) the total synthesis of frondosin B

        Goble, Stephen D Princeton University 2006 해외박사(DDOD)

        RANK : 2591

        Tandem C-O and C-C bond forming reactions, where oxygen functionalities can be installed with the requisite carbon-carbon bonds being formed in a single reaction step, can be a powerful synthetic tool for the manipulation of organic structures. One of the most important and well established versions of this type of reaction is the carboalkoxylation of alkenes, where a carbon atom and an oxygen atom are formally added across the unsaturation to give alkyl ethers. Such procedures usually take the form of alkoxycarbonylation reactions, where the carbon atom is derived from a carbonyl group or from carbon monoxide. These reactions have seen wide usage in organic synthesis. The carbooxidation of alkynes is far less studied and has seen little application in synthesis. This dissertation explores two different versions of such processes and their applications in synthesis. The first example to be introduced is the ruthenium-catalyzed addition of carboxylic acids to 1,6-diynes to give six-membered carbocyclic and heterocyclic ring systems. This reaction displays a novel formal reactivity pathway through transition metal catalysis---the formation of a cyclic diene with incorporation of a carboxylic acid from an acyclic diyne which assembles six-membered ring systems, in a field where five-membered ring formation, via addition-cyclization, is ubiquitous. The scope and utility of the reaction is explored as well as the utility of the reaction products. The mechanistic aspects of the reaction are also explored in detail and several rational mechanistic proposals for this reaction are presented. The second example to be introduced, will explore the endo-cyclative oxy-carbonylation reaction of ortho-alkynyl phenols in the context of the total synthesis of frondosin B. Although some of the formal reactions have been reported and explored, they have never seen any application in total synthesis. Several novel routes, centering around this general reaction theme, are presented.

      • College choice and college success: The role of individuals, institutions and policy

        Goble, Lisbeth J Northwestern University 2010 해외박사(DDOD)

        RANK : 2591

        Choosing a college is one of the first important decisions that many young adults undertake. Popular media suggests how students should find an appropriate college based on traditional practices (Hallet, 2008; Kulman, 2007), yet, many aspects of the reality experienced by new kinds of students and colleges is largely ignored in the college choice literature. This dissertation addresses key components of the college choice process to provide empirically-based evidence about what matters for traditional college students. The first study considers the antecedents to college enrollment and specifically unplanned enrollments. It addresses how students use college-related information, changes in this information over high school, and its relation to diverted or realized college enrollments. Findings suggest that information use varies greatly. Certain sources have positive impacts on student follow-through on four-year college plans. Counselors are found to be particularly important for low-SES students in the realization of their college plans. The second study focuses on issues of accountability in higher education by addressing policymakers' suggestions of using institutional graduation rates as a college choice criterion. This chapter examines the assumptions on which the use of graduation rates is based and how they compare with empirical reality. While graduation rate is an appealing criterion, this study shows that using institutional graduation rate would provide misleading or useless advice for most individuals. Other institutional measures -- percent part-time students and school selectivity (based on SAT scores) -- may be more useful in predicting degree completion. The third study focuses on the role of college proximity in college choice. It provides descriptive analysis of students' preferences for college location, where students attend college and how these relate to the colleges they attend and ultimate degree completion. There is great variability in student preferences for college and how far students travel for college. While actual distance to college is not related to degree completion outcomes for most students, it is related to the types of colleges that students attend. However, the preference for location is actually related to degree completion: those who prefer to go away having increased chances degree completion.

      • Evaluating the influence of university organizational characteristics and attributes on technology commercialization

        Goble, Lisa A The University of North Carolina at Chapel Hill 2013 해외박사(DDOD)

        RANK : 2591

        This dissertation project seeks to make a contribution to the growing body of literature on academic technology commercialization and the entrepreneurial efforts of faculty and students at US research universities. The academic environment across the United States has seen an increased emphasis on moving the results of academic research into the commercial sector. In addition to their core missions of education and basic research, universities are expected to have a larger role in stimulating regional and national economies. This dissertation project contributes to this growing body of literature on university technology commercialization efforts by summarizing findings on characteristics and factors known to have an influence technology transfer outcomes, evaluating a technology licensing consortium between three large research institutions, and empirically evaluating specific university and technology licensing office characteristics for their influence on the technology transfer process and its outcomes. Three related research studies contribute to this project. The motivating framework, background and context for the three research projects in this dissertation are presented in an introductory chapter. The literature review in Chapter 2 summarizes findings from a selection of studies evaluating characteristics and attributes of US universities, their technology licensing offices (TLOs), and regions that have an influence upon a university's involvement in technology commercialization efforts. Findings are summarized for how various characteristics influence the technology transfer process, invention disclosure from faculty, and subsequent licensing and startup formation form US research universities. Chapter 3 presents a case study of an early technology licensing consortium between three North Carolina universities: Duke University, The University of North Carolina at Chapel Hill, and North Carolina State University during 1988-1995. This consortium facilitated a growing entrepreneurial culture, increased patenting and technology licensing activities at each campus, and enabled the successful licensing of several academic inventions. In Chapter 4, an empirical analysis utilizes survey data from 76 universities to review potential correlations between university organizational and TLO characteristics and the metrics commonly reported by US research universities engaged in technology transfer. This research fills a gap in the literature by evaluating the potential influence TLO organizational reporting structure and characteristics of the TLO director may have on the technology commercialization efforts and outcomes of US research institutions. Chapter 5 integrates the general findings from the three projects, and outlines the significance of those findings for how characteristics of the university and TLO influence the technology transfer process and its outcomes. Implications and recommendations for university administrators and for policy development within the US university environment and their economic regions are discussed in this final chapter.

      • Examining Child-Centered and Direct Instruction Approaches to Early Education

        Goble, Priscilla Arizona State University 2014 해외박사(DDOD)

        RANK : 2591

        The majority of early education programs today use a mix of child-centered and direct instruction approaches. Existing research comparing educational approaches is limited in the degree to which it can inform practice in mixed-method classrooms (i.e., classrooms using both child-centered and direct instruction approaches). The current dissertation extended previous research examining child-centered and direct instruction approaches to early education in two studies. The first study explored how free play and guided play differ from one another. The second study examined how time spent in free play, guided play, and direct instruction in the fall related to children's school readiness in the spring. Both studies were conducted using mixed-method Head Start classrooms. Participants were preschool children (Study 1 n = 284, Study 2 n = 283; M age = 52 months, 48% girls, 70% Mexican or Mexican-American) from lower socioeconomic status families. Observational data were utilized to assess children's time spent in free play and guided play and experiences with activities and peers in each context. Children's academic, affective, and social readiness were assessed through child interviews and teacher reports. The results provided little evidence to support the hypotheses or the popularly held belief that guided play is the most beneficial context for learning and development in early education programs. Findings were discussed in terms of the strengths and limitations of the studies and directions for future research. Importantly, recommendations for policy and practice were provided.

      • Beautiful circuits: The mediated life in America, 1900--1940 (Henry James, James Weldon Johnson, Gertrude Stein, James Agee, William Carlos Williams)

        Goble, Mark Anton Stanford University 2002 해외박사(DDOD)

        RANK : 2591

        <italic>Beautiful Circuits: The Mediated Life in America, 1900–1940 </italic> examines the aesthetics and performance of communication in literature at a time when the once “new media” of the telegraph, telephone, phonograph, and cinema were becoming unremarkable in everyday life. I argue that a pervasive acculturation to these technologies inspired idealized forms of interaction and mutual understanding that depended on increasingly dramatic ways of being “mediated”—of experiencing any contact, however visceral or close, as both remote and entirely involved in the artifice and materiality of expression. Expanding on criticism that has looked narrowly at technology's stylistic influence on, and iconic place within, the world of American modernism, I am interested in figures who respond more broadly to the technical possibilities of media by trying to change how literature itself communicates. I show how the most striking aspects of modernity in texts by Henry James, James Weldon Johnson, Gertrude Stein, James Agee, and William Carlos Williams appear not so much when technology signals the shock of the new, but when technology turns every conceivable language of communication into a cunning and sophisticated “technique.” The dissertation considers the historical implications that follow on the rise of national and global communications networks, on an intensifying culture of celebrity, on a profound coupling of sexuality and technology, and on ever more extravagant attempts to record both racial identity and the archival past with absolute fidelity. The “mediated life” I describe puts technology into communication with a series of shifts in how Americans imagined both the mechanics and the meanings of their various connections—to each other, to the world, and to a diverse set of exhilarations and apprehensions around modernity itself. The project is thus a study of media in literature, and of literature <italic> as</italic> media—and though its readings concentrate on key writers and individual texts, its scope includes materials drawn from popular discourses of science and technology, visual culture of the period, silent and Hollywood narrative cinema, and sound recordings of early jazz and ragtime.

      • IDEOLOGIES OF MUSIC EDUCATION: A PRAGMATIC, HISTORICAL ANALYSIS OF THE CONCEPT "MUSIC" IN MUSIC EDUCATION IN THE UNITED STATES (CHARLES SANDERS PEIRCE)

        GOBLE, JAMES SCOTT THE UNIVERSITY OF MICHIGAN 1999 해외박사(DDOD)

        RANK : 2591

        The influx of students from diverse cultural backgrounds and the appearance of music from many different cultural traditions in the United States have raised a quandary among music educators over what music should be included in the music education curriculum of the nation's public schools. Also, support for public school music classes has been inconsistent throughout the history of the nation, since the varied and changing views held by the nation's citizens concerning the personal and societal importance of music have often made its inclusion in the curriculum difficult to justify. These two problems give rise to the question: What is the societal purpose of public school music education in the United States as an emerging post-modern society?. Applying the pragmatic philosophy of Charles Sanders Peirce to the forms of “musical activity” manifested in different world societies reveals these forms as a diverse cluster of community-specific behaviors or practices involving sound, each of which serves those who meaningfully participate in it as a vital means of psychosocial equilibration relative to the ideology—or ordered conception of Reality—they tacitly embody. It also reveals that awareness of the ideological particularity and the concomitant personal and societal benefit of participation in some form of “musical activity” have been obscured among United States citizens owing to certain factors stemming from the nation's constitutional separation of church and state and its embrace of democratic capitalism as its social system. The progressiveness of this obfuscation is reflected in the changing ways music educators have conceptualized “music” since the European colonization of North America began—first as a means of worship, later as a form of art, and more recently as a mere product of the human mind. Modifying music education curricula in United States public schools to introduce students gradually to different cultural forms of “musical activity” as culturally relative means of psychosocial equilibration would resolve the two problems cited above, raising public understanding of the human significance of “musical activity” and confirming the importance of public school music education for maintaining the egalitarian ideals of the nation.

      • Upper limb asymmetries in the utilization of movement-related sensory feedback

        Goble, Daniel J University of Michigan 2007 해외박사(DDOD)

        RANK : 2591

        While the preferred arm of right handed individuals has traditionally been viewed as being dominant with respect to motor output, non-preferred arm advantages have recently been described by this laboratory for the matching of target arm positions in the absence of vision. The aim of this dissertation, therefore, was to determine the extent to which this asymmetry reflects arm differences in the utilization of movement-related feedback. To accomplish this, three matching experiments were conducted using servomotor-driven manipulanda devices that recorded elbow position in the horizontal plane. In study 1, a comparison was made between the static position matching abilities of the two arms during visually versus proprioceptively-guided tasks. In this case, non-preferred arm accuracy was found to be enhanced during the proprioceptive task, whereas the preferred arm made smaller errors when targets were visual in nature. In study 2, arm differences in the ability to match proprioceptively-determined target movement speeds were assessed. This study showed that, unlike the sense of arm position, the acuity of dynamic proprioception sense was relatively similar for the two arms, except in the case of average acceleration matching where a non-preferred arm accuracy advantage was seen. Lastly, in the third study, the ability to coordinate both arm position and movement speed proprioceptive information was tested. In this case, absolute matching errors were again smaller for the non-preferred versus preferred arm. Overall, the results of this dissertation lend support to the notion that the two arms rely to different degrees on visual versus proprioceptive feedback. This asymmetry may reflect the roles played by the two arms during the performance of many bimanual activities of daily living where vision guides movements of the preferred arm, while the non-preferred arm plays a more assistive role utilizing primarily proprioceptive feedback.

      • Inside the echo chamber: The dynamic interaction of candidates, campaigns and citizens

        Goble, Hannah The University of Wisconsin - Madison 2009 해외박사(DDOD)

        RANK : 2591

        This dissertation addresses two overarching and related research questions: first, how do candidates shape their campaign strategy regarding issue coverage and emphasis, and, second, how do those strategic choices influence the electorate? It seeks to answer those questions in the contexts of the 2000 and 2004 presidential elections and 2000, 2002, and 2004 congressional elections in the United States. The data analyzed include information on candidate-sponsored television advertisements aired over the course of the general elections and public opinion surveys conducted over the same time periods. I argue that candidates, in efforts to prime issues and ultimately win elections, will incorporate a variety of considerations in their strategic calculus, including party issue ownership reputations; personal characteristics like sex and political expertise; electorate demographics like partisanship; and the nature of an individual issue, such as its public salience and whether it is an issue on which distinctions between opponents can be drawn. Moreover, these considerations and their relative strength vary from year to year and issue to issue, and hence, building a model of candidate issue emphasis requires a strong role for political context and points to the ineffectiveness of a single explanation. In addition, I argue that public responses to campaign activity will be seen but that such responses will generally be limited and conditional on voter characteristics like party identification and political sophistication. Thus, responses will be unevenly distributed among the electorate and, given the importance of the politics surrounding an individual issue, will vary across issues. The implications of this work center on the inadequacy on a single or combination of existing explanations of candidate issue emphasis to be broadly applicable without factoring in the context in which candidates run. The observed variation in candidate behaviors points particularly to the importance of a given issue's politics, especially the degree to which it is a politicized position issue. If it is, it becomes much more likely that candidates will incorporate the issues and engage in dialogue with their opponents.

      • Playable stories: Making programming and 3D role-playing game design personally and socially relevant

        Ingram-Goble, Adam Indiana University 2013 해외박사(DDOD)

        RANK : 2590

        This is an exploratory design study of a novel system for learning programming and 3D role-playing game design as tools for social change. This study was conducted at two sites. Participants in the study were ages 9-14 and worked for up to 15 hours with the platform to learn how to program and design video games with personally or socially relevant narratives. This first study was successful in that students learned to program a narrative game, and they viewed the social problem framing for the practices as an interesting aspect of the experience. The second study provided illustrative examples of how providing less general structure up-front, afforded players the opportunity to produce the necessary structures as needed for their particular design, and therefore had a richer understanding of what those structures represented. This study demonstrates that not only were participants able to use computational thinking skills such as Boolean and conditional logic, planning, modeling, abstraction, and encapsulation, they were able to bridge these skills to social domains they cared about. In particular, participants created stories about socially relevant topics without to explicit pushes by the instructors. The findings also suggest that the rapid uptake, and successful creation of personally and socially relevant narratives may have been facilitated by close alignment between the conceptual tools represented in the platform, and the domain of 3D role-playing games.

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