http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Gezici, Ali Riza (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model
Gezici, Ali Riza,Ergun, Ruchan,Gurel, Kamil,Yilmaz, Fahri,Okay, Onder,Bozdogan, Omer The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.46 No.1
Objective : To evaluate the potential effects of risedronate (RIS) which shows a higher anti-resorptive effect among bisphosphonates, after a posterolateral lumbar intertransverse process spinal fusion using both autograft and allograft in a rat model. Methods : A totoal of 28 Sprague-Dawley rats were randomized into 2 study groups. A posterolateral lumbar intertransverse process spinal fusion was peformed using both autograft and allograft in a rat model. Group I (control) received 0.1 mL of steril saline (placebo) and Group II (treatment) received risedronate, equivalent to human dose (10 ${\mu}g$/kg/week) for 10-weeks period. Results : The fusion rates as determined by manual palpation were 69% in the group I and 46% in the group II (p = 0.251). According to radiographic score, the spinal segment was considered to be fused radiographically in 7 (53%) of the 13 controls and 9 (69%) of the 13 rats treated with RIS (p = 0.851). The mean histological scores were 5.69 ${\pm}$ 0.13 and 3.84 ${\pm}$ 0.43 for the control and treatment groups, respectively. There was a significant difference between the both groups (p = 0.001). The mean bone density of the fusion masses was 86.9 ${\pm}$ 2.34 in the control group and 106.0 ${\pm}$ 3.54 in the RIS treatment group. There was a statistical difference in mean bone densities of the fusion masses comparing the two groups (p=0.001). Conclusion : In this study, risedronate appears to delay bone fusion in a rat model. This occurs as a result of uncoupling the balanced osteoclastic and osteoblastic activity inherent to bone healing. These findings suggest that a discontinuation of risedronate postoperatively during acute fusion period may be warranted.
-
Chaotic Harris hawks optimization algorithm
Gezici Harun,Livatyalı Haydar 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.1
Harris hawks optimization (HHO) is a population-based metaheuristic algorithm, inspired by the hunting strategy and cooperative behavior of Harris hawks. In this study, HHO is hybridized with 10 different chaotic maps to adjust its critical parameters. Hybridization is performed using four different methods. First, 15 test functions with unimodal and multimodal features are used for the analysis to determine the most successful chaotic map and the hybridization method. The results obtained reveal that chaotic maps increase the performance of HHO and show that the piecewise map method is the most effective one. Moreover, the proposed chaotic HHO is compared to four metaheuristic algorithms in the literature using the CEC2019 set. Next, the proposed chaotic HHO is applied to three mechanical design problems, including pressure vessel, tension/compression spring, and three-bar truss system as benchmarks. The performances and results are compared with other popular algorithms in the literature. They show that the proposed chaotic HHO algorithm can compete with HHO and other algorithms on solving the given engineering problems very successfully.
-
Ali Riza Gezici,Ruçhan Ergun 대한의학회 2010 Journal of Korean medical science Vol.25 No.1
Despite advances in neuroimaging and neurosurgical treatment modalities, spinal epidural abscess remains a challenging problem. Early diagnosis is often difficult and treatment is always delayed. Spinal epidural abscess usually develops in patients with predisposing factors such as IV drug abuse, senillity, diabetes mellitus, spinal attempts, alcoholism, immunosuppression, liver diseases and catheterizations. It is rarely seen in cervical region. A successful treatment is only possible with early diagnosis and accurate surgical and medical treatment. Optimal management is unclear and morbidity and mortality are significant. We present two adult haemodialysis patients with end-stage renal insufficiency who developed cervical epidural abscess following central venous catheter placement. Early surgical intervention is mandatory in cases those have progressive neurological deficit and spinal deformity,and this is also increases the success rate of medical therapy.
-
Role of Expression of Inflammatory Mediators in Primary and Recurrent Lumbar Disc Herniation
Dagistan, Yasar,Cukur, Selma,Dagistan, Emine,Gezici, Ali Riza The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1
Objective: To assess role of some inflammatory mediators in patients with primary and recurrent lumbar disc herniation. Expression of IL-6, transforming growth factor (TGF)-1, insulin-like growth factor (IGF)-1, and Bcl-2-associated X protein (BAX) have been shown to be more intense in the primary group than the recurrent goup, but this mediators may be important aspects prognostic. Methods: 19 patients underwent primary and revision operations between June 1, 2009 and June 1, 2014, and they were included in this study. The 19 patients' intervertebral disc specimens obtained from the primary procedures and reoperations were evaluated. Expression of IL-6, TGF-1, IGF-1, and BAX were examined immunohistochemically in the 38 biopsy tissues obtained from the primary and recurrent herniated intervertebral discs during the operation. Results: For IL-6 expression in the intervertebral disc specimens, there was no difference between the groups. The immunohistochemical study showed that the intervertebral disc specimens in the primary group were stained intensely by TGF-1 compared with the recurrent group. Expression of IGF-1 in the primary group was found moderate. In contrast, in the recurrent group of patients was mild expression of IGF-1. The primary group intervertebral disc specimens were stained moderately by BAX compared with the recurrent group. Conclusion: The results of our prognostic evaluation of patients in the recurrent group who were operated due to disc herniation suggest that mediators may be important parameters.
-
Association of TAP1 and TAP2 Gene Polymorphisms with Hematological Malignancies
Ozbas-Gerceker, Filiz,Bozman, Nazli,Gezici, Sevgi,Pehlivan, Mustafa,Yilmaz, Mehmet,Pehlivan, Sacide,Oguzkan-Balci, Sibel Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Transporter associated with antigen presenting (TAP) 1 and TAP2 genes are localized in the major histocompatability complex (MHC) class II region and form a heterodimer playing a key role in endogenous pathways for antigen presentation. Defects of these genes have been reported to be common in different types of cancer. Polymorphisms identified in these loci have also been investigated and reported to be associated with several autoimmune disorders, viral infections and neoplasms. In the present study, for the first time, the allele and genotype frequencies of TAP1-333, TAP2-565, TAP2-651 and TAP2-665 were determined in patients with hematological malignancies (HM) using a PCR-RFLP method and compared with the frequencies in the control group. Our results suggested an association of TAP1-333 polymorphism with multiple myeloma-MM and TAP2-565 polymorphism with chronic lymphoid leukemia-CLL. In addition, it could be concluded that the TAP2-665 GG genotype might be a risk factor for all types of hematological malignancies included in this study.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
