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      • One-dimensional ordered growth of magneto-crystalline and biocompatible cobalt ferrite nano-needles

        Ravichandran, M.,Oza, G.,Velumani, S.,Ramirez, J.T.,Garcia-Sierra, F.,Andrade, N.B.,Garza-Navarro, M.A.,Garcia-Gutierrez, D.I.,Asomoza, R. North-Holland 2014 Materials letters Vol.135 No.-

        <P>In this letter, we have reported a novel synthesis of CoFe2O4 nano-needles by a co-precipitation method using precursors of ferric chloride and cobalt nitrate at 80 degrees C. The structural and magnetic properties of as-grown needle-like CoFe2O4 nanostructures exhibit cubic spinel structure. CoFe2O4 nano-needles have an average diameter of 15 nm with an aspect ratio of 30:50, which was depicted by High-resolution transmission electron microscopy (HRTEM). Superconducting Quantum Interference Device (SQUID) confirmed the property of superparamagnetism. The magnetic measurement illustrated that the coercivity (Hc) of CoFe2O4 nano-needles increased from -145.84 Oe at 5 K to -25.38 Oe at 312 K. The cell viability studies of CoFe2O4 nano-needles were performed in the concentration range of 5-1000 mu g/ml on L6 (Skeletal muscle cell lines) and Hep-2 (Larynx carcinoma) cells using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. There was more than 50% cell viability for both the cell lines, but Hep-2 cells were more prone to killing as compared to L6 cells. Such biocompatible nanostructures can be used as drug-delivery systems for cancer therapeutics. (C) 2014 Elsevier B.V. All rights reserved.</P>

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