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Mingfeng Xiang,Yanqun Huang,Changjun Dai,Gaode Zou 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2
MicroRNA(miR)-340 is known as a multifunctionalmiRNA related to various types of cancer while itsrole in renal cell carcinoma (RCC) remains to be furtherinvestigated. In the present study, an apparent increase inmiR-340 expression was observed in both clear cell RCCtissues and RCC cell line 786-O and Caki-1. Functionally,the overexpression of miR-340 promoted cell proliferation,migration, invasion, extracellular alanine (Ala) level, andglycolysis level in 786-O cells. Then, frizzled class receptor3 (FZD3) was determined as the target gene of miR-340 andits expression level was negatively regulated by miR-340. The FZD3 silencing abrogated the inhibitory eff ect of miR-340 knockdown on cell proliferation, migration, invasion,Ala level, and glycolysis level in 786-O cells. In conclusion,miR-340 promotes proliferation, migration, and invasion ofRCC cells via suppressing FZD3 expression, and the promotioneff ect of miR-340 on RCC progression may be due to itsregulatory eff ect on glycolysis and Ala level.