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Development of a Magnetic-field Stimulation System for Cell Cultures in situ
G. Dominguez,S. Arias,Jose L. Reyes,Pablo Rogeli 한국자기학회 2017 Journal of Magnetics Vol.22 No.2
The effects of exposure to an extremely low-frequency magnetic field (25 ㎐ 20G) on animal cells have been studied. In some reports, stimulation was performed for fixed frequency and variations in magnitude; however, animal-cell experiments have established that both parameters play an important role. The present work undertook the modeling, simulation, and development of a uniform-magnetic-field generation system with variable frequency and stimulation intensity (0-60 ㎐, 1-25G) for experimentation with cell cultures in situ. The results showed a coefficient of variation less than 1% of the magnetic-field dispersion at the working volume, which is consistent with the corresponding simulation results demonstrating a uniform magnetic field. On the other hand, long-term tests during the characterization process indicated that increments of only 0.4℃ in the working volume temperature will not be an interfering factor when experiments are carried out in in situ cell cultures.
Genetic associations of LYN with systemic lupus erythematosus
Lu, R,Vidal, G S,Kelly, J A,Delgado-Vega, A M,Howard, X K,Macwana, S R,Dominguez, N,Klein, W,Burrell, C,Harley, I T,Kaufman, K M,Bruner, G R,Moser, K L,Gaffney, P M,Gilkeson, G S,Wakeland, E K,Li, Q-Z Macmillan Publishers Limited 2009 GENES AND IMMUNITY Vol.10 No.5
We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case–control association studies using populations of European-American, African-American and Korean subjects. Our combined European-derived population, consisting of 2463 independent cases and 3131 unrelated controls, shows significant association with rs6983130 in a female-only analysis with 2254 cases and 2228 controls (P=1.1 × 10<SUP>−4</SUP>, odds ratio (OR)=0.81 (95% confidence interval: 0.73–0.90)). This single nucleotide polymorphism (SNP) is located in the 5′ untranslated region within the first intron near the transcription initiation site of LYN. In addition, SNPs upstream of the first exon also show weak and sporadic association in subsets of the total European-American population. Multivariate logistic regression analysis implicates rs6983130 as a protective factor for systemic lupus erythematosus (SLE) susceptibility when anti-dsDNA, anti-chromatin, anti-52 kDa Ro or anti-Sm autoantibody status were used as covariates. Subset analysis of the European-American female cases by American College of Rheumatology classification criteria shows a reduction in the risk of hematological disorder with rs6983130 compared with cases without hematological disorders (P=1.5 × 10<SUP>−3</SUP>, OR=0.75 (95% CI: 0.62−0.89)). None of the 90 SNPs tested show significant association with SLE in the African American or Korean populations. These results support an association of LYN with European-derived individuals with SLE, especially within autoantibody or clinical subsets.Genes and Immunity (2009) 10, 397–403; doi:10.1038/gene.2009.19; published online 16 April 2009
The TANDEM Euratom project: Context, objectives and workplan
Vaglio-Gaudard C.,Dominguez Bautista M.T.,Frignani M.,Fütterer M.,Goicea A.,Hanus E.,Hollands T.,Lombardo C.,Lorenzi S.,Miss J.,Pavel G.,Pucciarelli A.,Ricotti M.,Ruby A.,Schneidesch C.,Sholomitsky S. 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.3
The TANDEM project is a European initiative funded under the EURATOM program. The project started on September 2022 and has a duration of 36 months. TANDEM stands for Small Modular ReacTor for a European sAfe aNd Decarbonized Energy Mix. Small Modular Reactors (SMRs) can be hybridized with other energy sources, storage systems and energy conversion applications to provide electricity, heat and hydrogen. Hybrid energy systems have the potential to strongly contribute to the energy decarbonization targeting carbon-neutrality in Europe by 2050. However, the integration of nuclear reactors, particularly SMRs, in hybrid energy systems, is a new R&D topic to be investigated. In this context, the TANDEM project aims to develop assessments and tools to facilitate the safe and efficient integration of SMRs into low-carbon hybrid energy systems. An open-source “TANDEM” model library of hybrid system components will be developed in Modelica language which, by coupling, will extend the capabilities of existing tools implemented in the project. The project proposes to specifically address the safety issues of SMRs related to their integration into hybrid energy systems, involving specific interactions between SMRs and the rest of the hybrid systems; new initiating events may have to be considered in the safety approach. TANDEM will study two hybrid systems covering the main trends of the European energy policy and market evolution at 2035’s horizon: a district heating network and power supply in a large urban area, and an energy hub serving energy conversion systems, including hydrogen production; the energy hub is inspired from a harbor-like infrastructure. TANDEM will provide assessments on SMR safety, hybrid system operationality and techno-economics. Societal considerations will also be encased by analyzing European citizen engagement in SMR technology safety.
Alternative optical concept for electron cyclotron emission imaging.
Liu, J X,Milbourne, T,Bitter, M,Delgado-Aparicio, L,Dominguez, A,Efthimion, P C,Hill, K W,Kramer, G J,Kung, C,Kubota, S,Kasparek, W,Lu, J,Pablant, N A,Park, H,Tobias, B American Institute of Physics 2014 Review of scientific instruments Vol.85 No.11
<P>The implementation of advanced electron cyclotron emission imaging (ECEI) systems on tokamak experiments has revolutionized the diagnosis of magnetohydrodynamic (MHD) activities and improved our understanding of instabilities, which lead to disruptions. It is therefore desirable to have an ECEI system on the ITER tokamak. However, the large size of optical components in presently used ECEI systems have, up to now, precluded the implementation of an ECEI system on ITER. This paper describes a new optical ECEI concept that employs a single spherical mirror as the only optical component and exploits the astigmatism of such a mirror to produce an image with one-dimensional spatial resolution on the detector. Since this alternative approach would only require a thin slit as the viewing port to the plasma, it would make the implementation of an ECEI system on ITER feasible. The results obtained from proof-of-principle experiments with a 125 GHz microwave system are presented.</P>