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RISS 인기검색어
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- 저자 : Francisco J. Martínez-Martín (검색결과 2 건)
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A parametric study of optimum tall piers for railway bridge viaducts
Francisco J. Martínez-Martín,Fernando González-Vidosa,Antonio Hospitaler,Víctor Yepes 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.6
This paper presents a parametric study of reinforced concrete bridge tall piers with hollow, rectangular sections. Such piers are typically used in railway construction of prestressed concrete viaducts. Twenty one different piers have been studied with seven column heights of 40, 50, 60, 70, 80, 90 and 100 m and three types of 10-span continuous viaducts, whose main span lengths are 40, 50 and 60 m. The piers studied are intermediate columns placed in the middle of the viaducts. The total number of optimization design variables varies from 139 for piers with column height of 40 m to 307 for piers with column height of 100 m. Further, the results presented are of much value for the preliminary design of the piers of prestressed concrete viaducts of high speed railway lines.
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MicroRNAs and periodontal disease: a qualitative systematic review of human studies
Pablo Micó-Martínez,Pedro J. Almiñana-Pastor,Francisco Alpiste-Illueca,Andrés López-Roldán 대한치주과학회 2021 Journal of Periodontal & Implant Science Vol.51 No.6
Purpose: MicroRNAs (miRNAs) are epigenetic post-transcriptional regulators that modulate gene expression and have been identified as biomarkers for several diseases, including cancer. This study aimed to systematically review the relationship between miRNAs and periodontal disease in humans, and to evaluate the potential of miRNAs as diagnostic and prognostic biomarkers of disease. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42020180683). The MEDLINE, Scopus, Cochrane Library, Embase, Web of Science, and SciELO databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs. Expression levels of miRNAs across the different groups were analysed using the collected data. Results: A total of 1,299 references were identified in the initial literature search, and 23 articles were finally included in the review. The study designs were heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-146a. Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls. In addition, many studies also focused on identifying target genes of the differentially expressed miRNAs that were significantly related to periodontal inflammation. Conclusions: The results of the studies that we analysed are promising, but diagnostic tests are needed to confirm the use of miRNAs as biomarkers to monitor and aid in the early diagnosis of periodontitis in clinical practice.
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