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RISS 인기검색어
- 검색키워드
- 저자 : Fatimah A. Alqahtani (검색결과 2 건)
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Manzoor Muhammad Usman,AlRashed Abdullah A.,Alghabban Fatimah A.,Alqahtani Sultan M.,Alturki Abdulrahman Y. 대한뇌혈관외과학회 2021 Journal of Cerebrovascular and Endovascular Neuros Vol.23 No.2
Giant internal carotid artery (ICA) aneurysms are complex vascular lesions which are difficult to treat with open as well as endovascular surgery. Parent vessel occlusion is a well-established treatment option for such aneurysms. However, there have been a few reported cases of ruptured aneurysms related to the persistent retrograde filling after parent vessel occlusion. We report a case which highlights the usage of the flow diverter stent as a potential treatment strategy for the management of retrograde filling of aneurysms. A 54-year-old female was found to have a giant left ICA aneurysm on a brain magnetic resonance imaging during workup for headaches. She underwent occlusion of the left ICA proximal to the aneurysm using multiple coils. However, follow up angiograms after 6 months and 2 years demonstrated persistent retrograde filling of the left ICA aneurysm through the posterior communicating (PCOM) artery. Eventually, she was successfully treated with a flow diverter stent across the PCOM artery into the distal ICA. Follow up angiogram after 6 months showed patent flow in the PCOM artery and the distal ICA. with complete occlusion of the aneurysm. Using a flow diverter stent after insufficient parent vessel occlusion for giant intracranial aneurysms may be a feasible treatment option and an addition to the neurovascular treatment armamentarium.
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Detection and Real-Time Monitoring of LDL-Cholesterol by Redox-Free Impedimetric Biosensors
Abdulaziz K. Assaifan,Fatimah A. Alqahtani,Sarah Alnamlah,Rasha Almutairi,Hend I. Alkhammash 한국바이오칩학회 2022 BioChip Journal Vol.16 No.2
In this work, non-faradaic impedimetric biosensor was developed for the direct detection of low-density lipoprotein (LDLcholesterol). Unlike other electrochemical techniques, non-faradaic electrochemical impedance spectroscopy (EIS) does not require the use of redox probes which denatures targeted biomarkers. Furthermore, no reference electrode is required for detection which is commercially viable. The biosensor reported here consists of LDL-antibodies attached to interdigitated gold electrodes via standard chemical functionalization. The biosensor demonstrated a sensitivity and limit of detection (LoD) of 70 nF/log(ng/mL) and 120 pg/mL, respectively, where the LoD is well below the recommended LDL level in blood. The biosensor also demonstrated good selectivity toward LDL. Thereafter we utilized, for the first time, the non-faradaic impedimetric biosensor for the continuous monitoring of LDL in phosphate buffer saline (PBS). The biosensor showed rapid responses to LDL injections. Such an approach is essential for the development of low-cost and scalable wearable biosensors for the direct real-time monitoring of chronic diseases and hence allows early medical interventions in cases where sudden increases in LDL or other biomarkers are deadly.
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