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LIN GUO,WENCE DING,FANDIAN MENG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.2
Folate-modi¯ed iron ferrite nanoparticles with high doxorubicin loading (FDMP) were developedfor dual targeting of tumor cells. Large quantities of doxorubicin and folate ligand were chemi-cally coupled to the synthesized dual-functional magnetic nanoparticles by using the multihandcross-linker poly-L-glutamic acid. FDMP exhibits high drug loading ability, narrow size distri-bution and pH sensitivity to drug release. The drug loading ratio and the magnetic response canbe adjusted by controlling the reactant ratio. FDMP possesses high magnetic-guided ability andexhibits enhanced uptake by folate receptors expressing tumor cells and increased cancer cellcytotoxicity.