Anxiety Sensitivity and Quality of Life in Patients with Acne

( Ersoy Acer ),( Ali Ercan Altınoz ),( Hilal Kaya Erdogan ),( Esra Agaoglu ),( Nihan Yuksel Canakcı ),( Zeynep Nurhan Saracoglu ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.4

Background: Anxiety sensitivity (AS) is a continuous fundamental fear and defined as extreme fear of anxiety sensations and symptoms. High AS can cause tendency to anxiety disorders. There are many studies evaluating the anxiety in patients with acne; however, AS has not been investigated. Objective: We aimed to investigate AS in patients with acne. Methods: Two hundred and fourteen acne patients and 117 healthy control subjects, aged older than 16 years were enrolled in the study. Severity of acne was evaluated by Global Acne Grading System. The acne patients and healthy controls were asked to complete the anxiety sensitivity index-3 (ASI-3), the Beck anxiety inventory (BAI) and the Turkish version of acne quality of life index. Results: Anxiety and AS levels in acne patients were significantly higher than healthy controls (p<0.001). Quality of life was impaired in acne patients. Quality of life was negatively correlated with anxiety and AS levels in acne patients (p=0.014, p=0.019, respectively). There was no correlation between quality of life and disease severity (p=0.556) and also there was no correlation between psychiatric scale scores (ASI-3, BAI) and disease severity (p=0.147, p=0.871, respectively). Conclusion: To our knowledge, our study is the first to report that AS is high in acne patients. Clinically, our results suggest that there might be a relationship between AS and acne. We conclude that further studies are needed in order to clarify the relationship between acne and AS and to investigate the efficacy of cognitive behavioral treatments in acne patients. (Ann Dermatol 31(4) 372∼377, 2019)

Local thin jacketing for the retrofitting of reinforced concrete columns

Yuce, Serkan Z.,Yuksel, Ercan,Bingol, Yilmaz,Taskin, Kivanc,Karadogan, H. Faruk Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.27 No.5

Two series of tests were conducted to investigate the behavior of local thin jacketing for the retrofitting of reinforced concrete (RC) columns. In the first series, four full-scale RC columns with a height of 400 cm and a 30 cm square cross-section were tested under constant axial load and reversed cyclic lateral displacements. The heavily damaged columns were retrofitted with local thin jacketing. Self-compacting concrete (SCC) was used in the production of 7.5 cm thick, four-sided jacketing. The height of the jacketing was 100 cm for one specimen and 200 cm for all others. In the second series, the retrofitted columns were retested with the same axial load and displacement history. The effectiveness of local thin jacketing in the retrofitting of RC columns was examined with respect to lateral strength, stiffness, inelastic load-deformation behavior and energy dissipation.

Development and Cyclic Behavior of U-Shaped Steel Dampers with Perforated and Nonparallel Arm Confi gurations

Kurtulus Atasever,Oguz C. Celik,Ercan Yuksel 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.5

Metallic dampers are sacrifi cial devices (fuses) that dissipate signifi cant energy during earthquakes while protecting other parts of structures from possible damage. In addition to numerous implementation opportunities of other base isolation systems, U-shaped dampers (UD) are one of the widely investigated and used devices in practice especially in Japan. The present study focuses on enhancing seismic performance of these types of dampers by changing their geometric properties. UDs with perforated (i.e. with holes) and/or nonparallel arms are developed for this purpose. For a better comparison, the criterion of equal material volume (or mass) has been utilized. Three dimensional fi nite element models of the new type of UDs are formed and investigated numerically under selected displacement histories. Based on the obtained hysteretic curves; dissipated energy intensities, eff ective stiff ness ratios, reaction forces, eff ective damping ratios are evaluated in this parametric study. It is found that both damper types have merits in use of seismic applications and that the selection of the damper confi guration is dependent on the design specifi c issues.

Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis

Erkan Yavuz,Onur Olgac Karagulle,Gulcin Ercan,Atilla Celik,Hakan Yigitbas,Busra Yaprak Bayrak,Rumeysa Tartar,Ramazan Kusaslan,Yuksel Altine,Osman Bilgin Gulcicek 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.4

Purpose: Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP. Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Prophylaxis group and treatment group were dosed ruscogenin by oral gavage for 14 days pre- and postradiation. At the end of the 28th day, all subjects were sacrificed. Results: Histopathological analysis showed a significant increase in cryptitis abscess, cryptitis and reactive atypia, and depth of lymphocytic infiltration of the control group, compared to the other groups (P < 0.05), while treatment and prophylaxis groups showed significant decreases (P < 0.05). Immunohistochemical analysis indicated that immunoreactivity were significantly higher in control group (P < 0.05, P < 0.001, and P < 0.01, respectively), but vice versa for treatment and prophylaxis groups. There was not any significant difference for fibroblast growth factor 2 immunoreactivity. The epithelium of control rectums indicated an increase in TNF-α immunoreactivity while other groups had significant decrease (P < 0.01). Electron microscopical findings were parallel to light microscopy. Conclusion: In this study, ruscogenin was observed to be effective on prophylaxis or treatment of acute RP. Although there are various reports on the treatment of the rectum damaged by acute RP in the literature, this could be the first study since there is no research indicating the ultrastructural effect of ruscogenin.

Numerical Modelling of Energy Dissipative Steel Cushions

Ahmet Gullu,Eleni Smyrou,Arastoo Khajehdehi,Hasan ozkaynak,I. Engin Bal,Ercan Yuksel,Faruk Karadogan 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.4

Energy dissipative steel cushions (EDSCs) are simple units that can be used to join structural members. They can absorb a substantial amount of seismic energy due to their geometric shapes and the ductile behavior of mild steel. Large deformation capability and stable hysteretic behavior were obtained in monotonic and cyclic tests of EDSCs in the framework of the SAFECLADDING project. Discrete numerical modeling strategies were applied to reproduce the experimental results. The fi rst and second models comprise two-dimensional shell elements and one-dimensional fl exural frame elements, respectively. The uncertain points in the preparation of the models included the mesh density, representation of the material properties, and interaction between contacting surfaces. A zero-length nonlinear link element was used in the third attempt in the numerical modeling. Parameters are recommended for the Ramberg–Osgood and bilinear models. The obtained results indicate that all of the numerical models can reproduce the response, and the stiff ness, strength, and unloading and reloading curves were fi tted accurately.

Uni-axial behavior of energy dissipative steel cushions

Hasan ozkaynak,Arastoo Khajehdehi,Ahmet Gullu,Faraz Azizisales,Ercan Yuksel,Faruk Karadogan 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.6

Seismic excitations may impart a significant amount of energy into structures. Modern structural design attitudes tend to absorb some part of this energy through special dissipaters instead of heavy plastic deformations on the structural members. Different types of dissipater have been generated and utilized in various types of structures in last few decades. The expected earthquake damage is mainly concentrated on these devices and they may be replaced after earthquakes. In this study, a low-cost device called <i>energy dissipative steel cushion</i> (EDSC) made of flat mild steel was developed and tested in the Structural and Earthquake Engineering Laboratory (STEELab) of Istanbul Technical University (ITU). The monotonic and cyclic tests of EDSC were performed in transversal and longitudinal directions discretely. Very large deformation capability and stable hysteretic behavior are some response properties observed from the tests. Load vs. displacement relations, hysteretic energy dissipation properties as well as the closed form equations to predict the behavior parameters are presented in this paper.

Association of Preoperative Risk Factors and Mortality in Older Patients following Emergency Abdominal Surgery: A Retrospective Cohort Study

Nadir Adnan Hacım,Ahmet Akbaş,Yigit Ulgen,Talar Vartanoglu Aktokmakyan,Serhat Meric,Merve Tokocin,Onder Karabay,Gulcin Ercan,Yuksel Altinel 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.4

Background: Older patients undergoing emergency laparotomy have high morbidity and mortality rates. Preoperative risk assessment with good predictors is an appropriate measure in this population. Frailty status is significantly associated with postoperative outcomes in older adults. This study aimed to investigate the effect of preoperative risk factors and frailty on short-term outcomes following emergency surgery for acute abdomen in older patients. Methods: This study included older patients (≥65 years of age) who underwent emergency abdominal surgery. We retrospectively analyzed their demographic and clinical variables and used the modified Frailty Index-11 to evaluate their frailty status. The primary outcome was the 30-day mortality rate. We also analyzed risk factors of mortality in these patients. Results: The study included 150 patients with a median age of 74 years. The mortality rate was 17.3% (n=26). We observed significantly higher mortality rates in patients who were obese and who had higher American Society of Anesthesiology (ASA grades) (p<0.05). Frailty status was worse in deceased group (p<0.001), when compared to individuals who survived. Septic shock was associated with the development of mortality (p<0.001). Multivariate regression analysis revealed that ASA grade was the only independent risk factor for mortality (odds ratio=19.642; 95% confidence interval, 3.886–99.274; p<0.001). Conclusion: Older patients with obesity and frailty presenting with higher ASA grades and septic shock had the worst survival following emergency abdominal surgery. The ASA grade was an independent risk factor for mortality.