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Eom, Sang-Yong,Moon, Sun-In,Yim, Dong-Hyuk,Lee, Chul-Ho,Kim, Guen-Bae,Kim, Yong-Dae,Kang, Jong-Won,Choe, Kang-Hyeon,Kim, Sung-Jin,Choi, Byung-Sun,Yu, Seung-Do,Chang, Soung-Hoon,Park, Jung-Duck,Kim, He The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.3
Background: Korean regression models for spirometric reference values are different from those of Americans. Using spirometry results of Korean adults, goodness-of-fits of the Korean and the USA Caucasian regression models for forced vital capacity (FVC) and forced expiratory volume in one second ($FEV_1$) were compared. Methods: The number of study participants was 2,360 (1,124 males and 1,236 females). Spirometry was performed under the guidelines of the American Thoracic Society and the European Respiratory Society. After excluding unsuitable participants, spirometric data for 729 individuals (105 males and 624 females) was included in the statistical analysis. The estimated FVC and $FEV_1$ values were compared with those measured. Goodness-of-fits for Korean and USA Caucasian models were compared using an F-test. Results: In males, the expected values of FVC and $FEV_1$ using the Korean model were 12.5% and 5.7% greater than those measured, respectively. The corresponding values for the USA Caucasian model were 3.5% and 0.6%. In females, the difference in FVC and $FEV_1$ were 13.5% and 7.7% for the Korean model, and 6.3% and 0.4% for the USA model, respectively. Goodness-of-fit for the Korean model regarding FVC was not good to the study population, but the Korean regression model for $FEV_1$, and the USA Caucasian models for FVC and $FEV_1$ showed good fits to the measured data. Conclusion: These results suggest that the USA Caucasian model correlates better to the measured data than the Korean model. Using reference values derived from the Korean model can lead to an overestimation regarding the prevalence of abnormal lung function.
Sung-Soo Park,Hee-Je Kim,Tong Yoon Kim,Joon yeop Lee,Jong Hyuk Lee,Gi June Min,Silvia Park,Jae-Ho Yoon,Sung-Eun Lee,Byung-Sik Cho,Ki-Seong Eom,Yoo-Jin Kim,Seok Lee,Dong-Wook Kim 대한혈액학회 2021 Blood Research Vol.56 No.3
Background Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative treatment option for acute leukemia. We aimed to identify the comorbidity factors affecting survival outcomes after alloSCT and develop a new comorbidity index tool for predicting overall survival (OS). Methods A Korean nationwide cohort of 3,809 adults with acute leukemia treated with alloSCT between January 2002 and December 2018 was analyzed as the development cohort. A retrospective cohort comprising 313 consecutive adults with acute leukemia who underwent alloSCT between January 2019 and April 2020 was analyzed as the validation cohort. Results In the development cohort, advanced age, male sex, and comorbidities such as previous non-hematologic malignancy, hypertension, and coronary or cerebral vascular disease were significantly related to poor OS. Subsequently, a new comorbidity scoring system was developed, and risk groups were created, which included the low-risk (score ≤0.17), intermediate-risk (0.17< score ≤0.4), high-risk (0.4< score ≤0.55), and very high-risk (score >0.55) groups. The 1-year OS rates were discriminatively estimated at 73.5%, 66.2%, 61.9%, and 50.9% in the low-risk, intermediate-risk, high-risk, and very high-risk groups in the development cohort, respectively (P<0.001). The developed scoring system yielded discriminatively different 1-year OS rates and 1-year incidence of non-relapse mortality according to the risk group (P=0.085 and P=0.018, respectively). Furthermore, the developed model showed an acceptable performance for predicting 1-year non-relapse mortality with an area under the curve of 0.715. Conclusion The newly developed predictive scoring system could be a simple and reliable tool helping clinicians to assess risk of alloSCT in adults with acute leukemia.
Eom, Jimi,Lee, Yu Ri,Lee, Jun Ho,Park, Sung Kyu,Jeong, Youngjin,Park, Jong S.,Kim, Yong-Hoon Elsevier 2019 Composites science and technology Vol.169 No.-
<P><B>Abstract</B></P> <P>In this paper, we demonstrate highly conductive and stretchable fiber interconnections for electronic textiles (e-textiles) using dry-spun carbon nanotube (CNT) fibers modified with ionic liquid (IL)/poly (vinylidene fluoride-<I>co</I>-hexafluoropropylene) (PVDF-HFP) copolymer composite. By adopting direct infiltration of CNT fibers with a mixture of 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide and PVDF-HFP, mechanical properties such as stretchability, maximum load and strain were significantly improved while minimizing the reduction in electrical conductivity. Such IL/PVDF modified CNT fibers (hybrid CNT fibers) exhibited electrical conductivity up to ∼1300 S/cm, with maximum load and strain values of 0.84 N and 35.7%, respectively. Using hybrid-CNT fibers, we demonstrated highly stretchable and electrically stable fiber interconnections for e-textiles by optimizing the interconnection pattern design. Particularly, by adopting a serpentine pattern, stretchability up to ∼70% and resistance variation of ∼2.7% at a tensile strain of 40% were achieved.</P>
( Sung-hwan Eom ),( Shin-kook Kang ),( Dae-sung Lee ),( Jeong-in Myeong ),( Jinhwan Lee ),( Hyun-woo Kim ),( Kyoung-ho Kim ),( Jae-young Je ),( Won-kyo Jung ),( Young-mog Kim ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.4
We evaluated the synergistic antibacterial effect in combination with the chitosan-ferulic acid conjugate (CFA) and β-lactam antibiotics, such as ampicillin, penicillin, and oxacillin, against methicillin-resistant Staphylococcus aureus (MRSA) using fractional inhibitory concentration (FIC) indices. CFA clearly reversed the antibacterial activity of ampicillin, penicillin, and oxacillin against MRSA in the combination mode. Among these antibiotics, the combination of oxacillin-CFA resulted in a ΣFICmin range of 0.250 and ΣFICmax of 0.563, suggesting that the oxacillin-CFA combination resulted in an antibacterial synergy effect against MRSA. In addition, we determined that CFA inhibited the mRNA expression of gene mecA and the production of PBP2a, which is a key determinant for β-lactam antibiotic resistance, in a dosedependent manner. Thus, the results obtained in this study supported the idea on the antibacterial action mechanism that oxacillin will restore the antibacterial activity against MRSA through the suppression of PBP2a production by CFA.