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Rukiye Sevinç Özakar,Emrah Özakar 한국고분자학회 2022 폴리머 Vol.46 No.2
Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sodium-Amp.Na) were successfully prepared using different polymers by the lyophilization technique. This study aims to prepare and characterize floating lyophilized tablets to understand the effect of different biopolymers on quality control parameters more clearly. Within the scope of characterization studies, many parameters were evaluated successfully. All tablets showed 24-hour release and had a mesoporous structure, as understood from the Brunauer-Emmett-Teller (BET) analysis. It has been determined from the Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses that Amp.Na doesn’t interact with excipients and is an amorphous form. These formulations can be used for other drugs in the future, and optimum properties can be easily characterized.