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RISS 인기검색어
- 검색키워드
- 저자 : Elzatahry, Ahmed A. (검색결과 4 건)
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Drug-clay nanohybrids as sustained delivery systems
Yang, J.H.,Lee, J.H.,Ryu, H.J.,Elzatahry, A.A.,Alothman, Z.A.,Choy, J.H. Elsevier 2016 Applied clay science Vol.130 No.-
<P>Biocompatible 2-dimensional layered compounds such as clays and layered double hydroxides (anionic clays) have been explored and utilized in drug delivery system for therapeutic application because they can safely encapsulate drug molecules via intercalation reaction. Therefore, various kinds of drug molecules and bio-functional molecules with cationic or anionic charge have been incorporated into clay delivery carriers, giving rise to the heterostructured layered nanohybrids with chemo-therapeutic and gene-therapeutic functions. Recently, such inorganic delivery systems have received growing attention because their inertness and low toxicity gives rise to safety and stability in bio-systems. Furthermore, the hybridization of drug with clays offers the fascinating features such as controlled and sustained release, improved water-solubility, and even protective and targeted delivery. Unique release behaviors of drugs from the drug-clay nanohybrids are originated from molecular level incorporation, and strong interaction between drug and inorganic layers including electrostatic and hydrogen bonding interactions. In the present review, various drug-clay nanohybrids will be introduced, and their recent development will be highlighted in the viewpoint of oral administration drugs with controlled and sustained release. (C) 2016 Elsevier B.V. All rights reserved.</P>
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Park, D.H.,Yang, J.H.,Vinu, A.,Elzatahry, A.,Choy, J.H. Elsevier ; King Saud University 2016 Arabian journal of chemistry Vol.9 No.2
<P>Intercalation reactions can be achieved through ion-exchange, pillaring, and exfoliation-reassembling reactions to explore new intercalation compounds with desired electronic, electrochemical, and optical functions. Such intercalative nanohybrids with lamellar or porous structure have received much attention due to their potential applications such as catalysts, electrodes, selective adsorbents, stabilizing agents, and even drug delivery systems. In this review, we briefly introduce and highlight X-ray diffraction and X-ray absorption spectroscopy studies on the intercalative nanohybrids to understand their intracrystalline and electronic structures along with physicochemical functions. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.</P>
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Farooq, Muhammad,Taha, Nael Abu,Butorac, Rachel R,Evans, Daniel A,Elzatahry, Ahmed A,Wadaan, Mohammad AM,Cowley, Alan H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Nanoparticles of gold and silver are offering revolutionary changes in the field of cancer therapy. N-heterocyclic carbene (NHC) metal complexes possess diverse biological activities and are being investigated as potential chemotherapeutic agents. The purpose of this study was to examine the cytotoxicity and possible mechanisms of action of two types of newly synthesized nanofiber composites containing BIAN N-heterocyclic gold carbene complexes in two types of human cancer cells, namely breast cancer (MCF7) and liver cancer (HepG2) cells and also in normal human embryonic kidney cells (HEK 293). Materials and Methods: Cytotoxicity was assessed by MTT cell viability assay and oxidative stress by checking the total glutathione level. Results: Both compounds affected the cell survival of the tested cell lines at very low concentrations (IC50 values in the micro molar range) as compared to a well-known anti-cancer drug, 5 fluorouracil. A 60-80% depletion in total glutathione level was detected in treated cells. Conclusions: Reduction in total glutathione level is one of the biochemical pathways for the induction of oxidative stress which in turn could be a possible mechanism of action by which these compounds induce cytotoxicity in cancer cell lines. The in vitro toxicity towards cancer cells found here means that these molecules could be potential anticancer candidates.
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Yang, Jae-Hun,Zhang, Wei,Ryu, Hyunju,Lee, Ji-Hee,Park, Dae-Hwan,Choi, J. Yoon,Vinu, Ajayan,Elzatahry, Ahmed A.,Choy, Jin-Ho The Royal Society of Chemistry 2015 Journal of Materials Chemistry A Vol.3 No.45
<▼1><P>The thermal stability of PP was significantly improved after the formation of PP nanocomposites with organo-LDH, which was affected by the type of organic modifier in organo-LDH and the loading amount of organo-LDH.</P></▼1><▼2><P>Organo-layered double hydroxide/polypropylene (LDH/PP) nanocomposites were successfully synthesized <I>via</I> a solution blending method. As an attempt to improve the compatibility with hydrophobic PP, the LDH surface was modified by the incorporation of various anionic surfactants <I>via</I> electrostatic interaction with LDH cationic layers. Surfactants were selected by considering the aliphatic carbon chain length (laurate, palmitate, stearate and dodecyl sulfate) and anionic functional groups (–COO<SUP>−</SUP>, –OPO3<SUP>2−</SUP>, and –OSO3<SUP>−</SUP>) with the purpose of optimizing the homogeneous dispersion in the PP matrix. In PP nanocomposites containing LDH modified with alkyl carboxylate, the (00<I>l</I>) X-ray diffraction (XRD) peaks originating from organo-LDH were not observed, indicating that organo-LDH layers were fully exfoliated and homogeneously dispersed within the PP matrix, which were also confirmed by cross-sectional TEM analysis. However, PP nanocomposites containing LDH modified with dodecyl sulfate and lauryl phosphate showed broad (00<I>l</I>) XRD peaks, indicating that organo-LDH was partially exfoliated. According to the thermogravimetric analysis, the thermal stability (<I>T</I>0.5) of organo-LDH/PP nanocomposites was significantly improved by 37–60 K, depending on the type and loading content of organo-LDH compared to that of pristine PP. PP nanocomposites containing well-dispersed organo-LDH showed substantial enhancement of the elastic modulus with little decrease of tensile strength. These results are due to the increased interface volume fraction provided by the exfoliated LDH nanosheets.</P></▼2>
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