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Nam, Seoung Wan,Lee, Kwang Seob,Yang, Jae Won,Ko, Younhee,Eisenhut, Michael,Lee, Keum Hwa,Shin, Jae Il,Kronbichler, Andreas The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.5
The publication of genetic epidemiology meta-analyses has increased rapidly, but it has been suggested that many of the statistically significant results are false positive. In addition, most such meta-analyses have been redundant, duplicate, and erroneous, leading to research waste. In addition, since most claimed candidate gene associations were false-positives, correctly interpreting the published results is important. In this review, we emphasize the importance of interpreting the results of genetic epidemiology meta-analyses using Bayesian statistics and gene network analysis, which could be applied in other diseases.
The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis
Lee, Keum Hwa,Yang, Jae Won,Cho, Jin Young,Lee, Joo Yup,Lim, Eun Kyung,Eisenhut, Michael,Jeong, Dong Yeon,Steingroever, Johanna,Shin, Jae Il Korean Society of Pediatric Nephrology 2018 Childhood kidney diseases Vol.22 No.1
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis
Keum Hwa Lee,양재원,Jin Young Cho,Joo Yup Lee,Eun Kyung Lim,Michael Eisenhut,Dong Yeon Jeong,Johanna Steingroever,신재일 대한소아신장학회 2018 Childhood kidney diseases Vol.22 No.1
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
Treatment of refractory IgA vasculitis with dapsone: a systematic review
Lee, Keum Hwa,Hong, Sung Hwi,Jun, Jinhae,Jo, Youngheun,Jo, Woogyeong,Choi, Dayeon,Joo, Jeongho,Jung, Guhyun,Ahn, Sunghee,Kronbichler, Andreas,Eisenhut, Michael,Shin, Jae Il The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.5
IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved 13 articles published until June 14, 2018. The most common clinical feature was a palpable rash (100% of patients), followed by joint pain (69.2%). Treatment response within 1-2 days was observed in 6 of 26 patients (23.1%) versus within 3-7 days in 17 patients (65.4%). Relapse after treatment discontinuation was reported in 17 patients (65.4%) but not in 3 patients (11.5 %). Four of the 26 patients (15.4%) reported adverse effects of dapsone including arthralgia (7.7%), rash (7.7%), and dapsone hypersensitivity syndrome (3.8%). Our findings suggest that dapsone may affect refractory IgA vasculitis. Multicenter randomized placebo-controlled trials are necessary to determine the standard dosage of dapsone at initial or tapering of treatment in IgA vasculitis patients and evaluate whether dapsone has a significant benefit versus steroids or other medications.