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沈光淑,金德浩 중앙대학교 기술과학연구소 1981 기술과학연구소 논문집 Vol.8 No.-
The nuclear structure and the nuclear reaction mechanism can be comprehended by the study of heavy-ions reactions. Elastic scattering of heavy-ions induced by ?? on ??, ??, ?? and ?? have been studied at laboratory incident energies between 155 MeV and 170 MeV. The total reaction cross-sections and the interaction radius parameters were obtained by the opticalmodel analysis and the quarter-point recipe which can be derived from the measured angular distributions of elastic scattering.
可逆計數器와 減算器를 利用한 直流電動機의 計數的인 速度制御
沈鍾輔,金德奎 경북대학교 공과대학 1982 工大硏究誌 Vol.11 No.-
Up-down counter and subtractor-controlled digital speed control system of DC motor has been designed. The prototype's step response overshoot was less than 6% and steadystate error was less than ± 0.2%
한민철,김재헌,박성재,변동원,강덕희,심봉석 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.2
Renal cell carcinoma can presents wide range of signs and symptoms, and commonly associated with paraneoplastic syndrome. Paraneoplastic manifestations are present in up to 20% of patients with renal cell carcinoma. There is convincing evidence that renal cell carcinoma tumor cells elaborate proteins that serve as mediators of endocrine (ex ; ectopic production of parathyroid hormone-related protein or erythropoietin) as well as nonendocrine paraneoplastic syndromes. A paraneoplastic syndrome may be the various clinical presentation of renal cell carcinoma in a significant number of patients, therefore mimicked other general disease. We report a case of renal cell carcinoma associated with paraneoplastic syndrome mimicking pyelonephritis.
양장군,김병완,심덕선 중앙대학교정보통신연구소 2000 정보통신연구소논문집 Vol.2 No.1
본 논문에서는 GPS 항법 시스템에 Least square Method. Direct Solution Method, Improved Direct Solution Method, Kalman Filter 등 여러 항법 알고리즘을 사용하여 각각의 방법에 대하여 SA(Selective Availability) 오차(2000년 5월 1일부터 제거됨) 및 여러 오차요인의 영향에 따른 알고리즘들의 추정성능을 모의실험을 한 후 그 성능을 비교 분석하였다. 알고리즘별로 성능에는 큰 차이가 없었으며 SA가 없을 때 서울지역에서는 수평면오차(2drms)가 8m 이내, 위도 경도가 0˚인 지역에서는 2m 이내로 들어옴을 알 수 있었다. In this paper, positioning performance according to the effect of SA and Tropospheric error, Ionospheric error is tested comparing Least Square Method. Direct Solution Method, Improved Direct Solution Method and Kalman Filter Method that are used navigation algorithms for GPS receiver. Considering only Tropospheric error and Ionospheric error, simulation shows that horizontal estimation error is less than 8m(2drms) at Seoul area and less than 2m(2drms) at the point where latitude and longitude are all zero.
Kim, Duk-jae,Shim, Yeun-keun,Park, Jeongwon,Kim, Hyung-jun,Han, Jeon-geon Institute of Pure and Applied Physics 2016 Japanese Journal of Applied Physics Vol.55 No.4
<P>Nonthermal atmospheric-pressure plasma discharge is designed with low-temperature cofired ceramic (LTCC) electrodes to achieve dielectric barrier surface discharge (DBSD). The environmental requirement (below 0.05 ppm) of the amount of byproducts (ozone and NOx) produced during the process was met by optimizing the electrode design to produce a high dielectric barrier discharge for low-voltage (similar to 700 V) operation and minimizing the distance between electrodes to improve the plasma discharging efficiency. The concentrations of volatile organic compounds (VOCs) within interior cabins of commercial vehicles were significantly reduced after 1-h treatment to improve air quality cost-effectively. This atmospheric-pressure plasma process was demonstrated for the sterilization of Escherichia coli to prevent food poisoning during the preservation of food in refrigerators. (C) 2016 The Japan Society of Applied Physics</P>
Kim, Dong Hyun,Lee, Dahm,Chang, Eun Hyuk,Kim, Ji Hyun,Hwang, Jung Won,Kim, Ju-Yeon,Kyung, Jae Won,Kim, Sung Hyun,Oh, Jeong Su,Shim, Sang Mi,Na, Duk Lyul,Oh, Wonil,Chang, Jong Wook Mary Ann Liebert 2015 STEM CELLS AND DEVELOPMENT Vol.24 No.20
<P>Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus of a transgenic mouse model of Alzheimer's disease (AD) reduced amyloid-관 (A관) plaques and enhanced cognitive function through paracrine action. Due to the limited life span of hUCB-MSCs after their transplantation, the extension of hUCB-MSC efficacy was essential for AD treatment. In this study, we show that repeated cisterna magna injections of hUCB-MSCs activated endogenous hippocampal neurogenesis and significantly reduced A관42 levels. To identify the paracrine factors released from the hUCB-MSCs that stimulated endogenous hippocampal neurogenesis in the dentate gyrus, we cocultured adult mouse neural stem cells (NSCs) with hUCB-MSCs and analyzed the cocultured media with cytokine arrays. Growth differentiation factor-15 (GDF-15) levels were significantly increased in the media. GDF-15 suppression in hUCB-MSCs with GDF-15 small interfering RNA reduced the proliferation of NSCs in cocultures. Conversely, recombinant GDF-15 treatment in both in vitro and in vivo enhanced hippocampal NSC proliferation and neuronal differentiation. Repeated administration of hUBC-MSCs markedly promoted the expression of synaptic vesicle markers, including synaptophysin, which are downregulated in patients with AD. In addition, in vitro synaptic activity through GDF-15 was promoted. Taken together, these results indicated that repeated cisterna magna administration of hUCB-MSCs enhanced endogenous adult hippocampal neurogenesis and synaptic activity through a paracrine factor of GDF-15, suggesting a possible role of hUCB-MSCs in future treatment strategies for AD.</P>
Kim, Ji-Eon,Cho, Hyun-Jong,Kim, Jung Sun,Shim, Chang-Koo,Chung, Suk-Jae,Oak, Min-Ho,Yoon, In-Soo,Kim, Dae-Duk Informa UK Ltd. 2013 Xenobiotica Vol.43 No.7
<P>1. Doxorubicin exhibited dose-independent pharmacokinetics after intravenous (5-20 mg/kg) and oral (20-100 mg/kg) administration to rats. Nearly all (82.1-99.7%) of the orally administered doxorubicin remained unabsorbed, and the hepatic first-pass extraction ratio and oral bioavailability of doxorubicin were approximately 0.5% and 1%, respectively. Based on these results, it is likely that the primary factor responsible for the low oral bioavailability of doxorubicin is the limited intestinal absorption, rather than the CYP3A4-mediated first-pass metabolism.</P><P>2. Moreover, the <I>in vitro</I> transport and cellular uptake studies using Caco-2 cell monolayers have revealed that doxorubicin crosses the intestinal epithelium primarily via the paracellular pathway (accounting for 85.6% of the overall absorptive transport) probably due to its physicochemical properties (hydrophilic cation; p<I>K</I><SUB>a</SUB> = 9.67, log <I>P</I> = −0.5). These results suggest that P-glycoprotein (P-gp)-mediated efflux activity does not play a significant role in limiting the intestinal absorption of doxorubicin, attenuating the absorptive transport by only 5.56-13.2%.</P><P>3. Taken together, the present study demonstrated that the limited and paracellular intestinal absorption of doxorubicin was a major factor responsible for its low oral bioavailability, restricting the role of CYP3A4-mediated first-pass metabolism and P-gp-mediated efflux.</P>
A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis
Kim, Yun Ji,Ryu, Seung Lok,Shim, Jae Won,Kim, Duk Soo,Shim, Jung Yeon,Park, Moon Soo,Jung, Hye Lim The Korean Society of Pediatric Gastroenterology 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.2
Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used in oriental medicine to treat various symptoms in Korea, however, several herbs have been reported to induce liver injury. We report a case of toxic hepatitis induced by Hovenia dulcis in a 3-year-old boy. He complained of nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with hovenia dulcis for about 1 year prior to presentation. A diagnosis of toxic hepatitis was made based on his history, laboratory data, viral markers, ultrasonography, and biopsied liver tissue. We administered supportive management for acute fulminant hepatitis but his symptoms and liver function progressed. He was transferred to another hospital for further evaluation and consideration for liver transplantation. Because acute liver failure due to herbs or dietary supplement taken for a long time is often fetal, it is important to make early diagnosis and stop taking the drug as soon as drug induced liver injury is suspected.
Kim, Yujin,Jin, DongHao,Lee, Bo Bin,Cho, Eun Yoon,Han, Joungho,Shim, Young Mog,Kim, Hong Kwan,Kim, Duk-Hwan Elsevier 2016 JOURNAL OF THORACIC ONCOLOGY Vol.11 No.12
<P>Conclusions: The present study suggests that simultaneous overexpression of beta-catenin and cyclin D1 may be associated with poor overall survival irrespective of platinum-based adjuvant chemotherapy in stage IA-IIA squamous cell carcinoma of the lung. (C) 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.</P>