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RISS 인기검색어
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- 저자 : Donoff, R. Bruce (검색결과 1 건)
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Urban, Scott D.,Aram Elovic,Randy Todd,Gallagher, George T.,Donoff, R. Bruce,Wong, David T. W. Korean Academy of Oral Biology and the UCLA Dental 1998 International Journal of Oral Biology Vol.23 No.2
Malignant ameloblastoma is characterized by aggressive behavior and a poor prognosis. No histomorphologic criteria exist to differentiate malignant ameloblastoma from their benign, locally-aggressive counterparts. However, biological markers such as histone (H3) expression have proven to be an important indicator of bioaggressive potential and may be a useful predictor of disseminated ameloblastoma. We hypothesize that malignant ameloblastoma, while histologically identical to their benign counterparts, will have a demonstrably higher proliferation rate by histone (H3) mRNA labeling. Seven cases of formalin-fixed, paraffin-embedded tissues from surgical biopsies of mandibular follicular ameloblastomas were obtained. One of the seven specimens was obtained from an ameloblastoma which metastasized to the right and left lungs. Proliferation rates were determined using RNA in situ hybridization with ^35S-labeled histone (H3) antisense and sense riboprobes. A blinded correlative assessment was made between the labeling index of H3 and the clinical outcome. The quantitative tumor labeling index of the malignant ameloblastoma (HLI=0.329) was higher than the indices of the benign, locally aggressive ameloblastomas (HLI=0.049 to 0.111). This preliminary examination suggests that the basis of the rare metastatic behavior of ameloblastoma is possibly a reflection of an elevated cellular proliferation rate.
RISS
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