Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?

Gökmen Asan,Mehmet Emin Derin,Halef Okan Doğan,Meliha Bayram,Mehtap Şahin,Ali Şahin 대한의학회 2020 Journal of Korean medical science Vol.35 No.10

Background: Familial Mediterranean fever (FMF) is an autoinflammatory disease that has self-limiting inflammatory attacks during polyserositis. Hepcidin is a protein, and interleukin-6 stimulation increases hepcidin levels. Calprotectin (CLP) is a recently defined cytokine released from monocytes and neutrophils in response to tissue trauma and inflammation. There are studies in the literature showing that it can be used as a biomarker in rheumatic diseases such as ankylosing spondylitis and rheumatoid arthritis. Here, we compared the levels of hepcidin and CLP in healthy individuals and FMF patients during an attack-free period and show its relation to genetic mutations. Methods: This is a cross-sectional study. Between July 2017 and December 2017, 60 patients diagnosed with FMF an admitted to the Cumhuriyet University Faculty of Medicine Department of Internal Medicine Rheumatology as well as 60 healthy volunteers without any rheumatic, systemic, or metabolic diseases were enrolled in this study. Blood was collected from a peripheral vein to measure serum CLP and hepcidin levels. Blood tests were examined by ELISA; the study protocol was approved by the local ethics committee. Results: Median serum hepcidin level was 468.1 (210.3–807.8) pg/mL in FMF group and 890.0 (495.0–1,716.9) pg/mL in the healthy control (HC) group. There was a statistically significant difference between the two groups (P < 0.001). The median serum levels of CLP in the FMF group were measured as 1,331.4 (969.3–1,584.6 pg/mL and 73.8(45.0–147.9) pg/ mL in the HC group. There was a statistically significant difference between the two groups (P < 0.001). Receiver operating characteristic analysis showed that the sensitivity was 66.7% and the specificity was 71.7% at serum hepcidin < 581.25 pg/mL (P < 0.05); the sensitivity was 96.7% and specificity was 100% at CLP > 238 pg/mL (P < 0.05). There was no significant difference between serum hepcidin and CLP levels in FMF patients with M694V homozygous and M694V heterozygous (P > 0.05). There was no significant difference in serum hepcidin levels between FMF patients with and without arthritis, proteinuria, and amyloidosis (P < 0.05). There was no significant correlation between laboratory findings, gender, age, and serum CLP and hepcidin levels (P > 0.05, r < 0.25). Conclusion: Serum CLP levels in FMF patients during an attack-free period are significantly higher than in the HC groups. Serum hepcidin levels in FMF patients are significantly lower than in the HC group. Low levels of hepcidin may be explained by including FMF patients during an attack-free period in the study. CLP may be an important biomarker in FMF. A better understanding of the role of these biomarkers in the diagnosis of FMF is needed to evaluate the results in a more comprehensive way.

An improved particle swarm optimizer for steel grillage systems

Ferhat Erdal,Erkan Doğan,Mehmet Polat Saka 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.4

In this paper, an improved version of particle swarm optimization based optimum design algorithm (IPSO) is presented for the steel grillage systems. The optimum design problem is formulated considering the provisions of American Institute of Steel Construction concerning Load and Resistance Factor Design. The optimum design algorithm selects the appropriate W-sections for the beams of the grillage system such that the design constraints are satisfied and the grillage weight is the minimum. When an improved version of the technique is extended to be implemented, the related results and convergence performance prove to be better than the simple particle swarm optimization algorithm and some other metaheuristic optimization techniques. The efficiency of different inertia weight parameters of the proposed algorithm is also numerically investigated considering a number of numerical grillage system examples.

The role of serum lipoxin A4 levels in the association between periodontal disease and metabolic syndrome

Esra Sinem Kemer Doğan,Burak Doğan,Özlem Fentoğlu,Fatma Yeşim Kırzıoğlu 대한치주과학회 2019 Journal of Periodontal & Implant Science Vol.49 No.2

Purpose: An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS. Methods: Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses. Results: Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL). Conclusions: The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.

Solving design optimization problems via hunting search algorithm with Levy flights

Erkan Doğan 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.2

This study presents a hunting search based optimum design algorithm for engineering optimization problems. Hunting search algorithm is an optimum design method inspired by group hunting of animals such as wolves, lions, and dolphins. Each of these hunters employs hunting in a different way. However, they are common in that all of them search for a prey in a group. Hunters encircle the prey and the ring of siege is tightened gradually until it is caught. Hunting search algorithm is employed for the automation of optimum design process, during which the design variables are selected for the minimum objective function value controlled by the design restrictions. Three different examples, namely welded beam, cellular beam and moment resisting steel frame are selected as numerical design problems and solved for the optimum solution. Each example differs in the following ways: Unlike welded beam design problem having continuous design variables, steel frame and cellular beam design problems include discrete design variables. Moreover, while the cellular beam is designed under the provisions of BS 5960, LRFD-AISC (Load and Resistant Factor Design-American Institute of Steel Construction) is considered for the formulation of moment resisting steel frame. Levy Flights is adapted to the simple hunting search algorithm for better search. For comparison, same design examples are also solved by using some other well-known search methods in the literature. Results reveal that hunting search shows good performance in finding optimum solutions for each design problem.

Neuralgic amyotrophy associated with COVID-19 infection: the broken bough

( Yahya Doğan ),( Murat Kara ),( Kübra Çetin Doğan ),( Bayram Kaymak ),( Levent Özçakar ) 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.2

Effect of Treadmill Backward Walking Training on Motor Capacity in Cerebral Palsy: A Randomized Controlled Study

Halis Doğan,Fatma Mutluay 대한재활의학회 2023 Annals of Rehabilitation Medicine Vol.47 No.2

Objective To evaluate treadmill backward walking training (BWT) effects on walking speed, balance, mobility, and walking endurance in children with cerebral palsy (CP). Methods The study evaluated 41 children with CP (age, 6–18; Gross Motor Function Classification System levels I and II). They were randomly allocated into control and BWT groups. BWT was applied (two sessions/week, 15 min/session for 8-week) to BWT group after the neurodevelopmental-based physiotherapy program routinely followed by all participants while the control group did not receive BWT. 10-Meter Walk Test (10MWT), Pediatric Balance Scale (PBS), Timed Up and Go Test (TUG), and Two-Minute Walk Test (2MWT) were selected as outcome measures for assessing walking speed, balance, mobility and endurance respectively. Results In BWG, 2MWT distance (3.5%), PBS (3.5%) increased significantly, and TUG decreased by 5.1% (all p<0.001) after training, 10MWT was shorter by 6.1% for BWG, corresponding to 7.4% faster walking speed (p<0.01). Control group assessment variations were stationary and not statistically significant. Conclusion Backward treadmill walking training induces small but statistically significant motor capacity improvements in children with CP.

ON ADJOINT CURVES OF FRAMED CURVES AND SOME RULED SURFACES

( Bahar Doğan Yazıcı ),( Sıddıka Özkaldı Karakuş ),( Murat Tosun ) 호남수학회 2023 호남수학학술지 Vol.45 No.3

In this study, we introduce the adjoint curves of framed curves. We examine some characterizations of adjoint curve of a framed curve. In addition, we give the conditions for framed curves and adjoint curves to be Bertrand and Mannheim curves. Then, we introduce adjoint curves of Frenet-type framed curves and give ruled surfaces related to adjoint curves. Finally, we create normal and binormal surfaces of the framed adjoint curves and obtain some characterizations of these surfaces and we support by the results with figures.

Investigation of the effect of bolt diameter and end plate thickness change on bolt column-beam connection

Samet Oğuzhan Doğan,Şenol Gürsoy,Ramazan Özmen 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.2

Several types of column-beam connections are used in the design of steel structures. This situation causes different cross-section effects and, therefore, different displacements and deformations. In other words, connection elements such as welds, bolts, continuity plates, end plates, and stiffness plates used in steel column-beam connections directly affect the section effects. This matter reveals the necessity of knowing the steel column-beam connection behaviours. In this article, behaviours of bolted column-beam connection with end plate widely used in steel structures are investigated comparatively the effects of the stiffness plates added to the beam body, the change in the end plate thickness and bolt diameter. The results obtained reveal that the moment and force carrying capacity of the said connection increases with the increase in the end plate thickness and bolt diameter. In contrast, it causes the other elements to deform and lose their capacity. This matter shows that optimum dimensions are very important in steel column-beam connections. In addition, it has been seen that adding a stiffness plate to the beam body part positively contributes to the connection’s moment-carrying capacity.

A Diagnosis to Consider in an Adult Patient with Facial Features and Intellectual Disability: Williams Syndrome

Özlem Akgün Doğan,Pelin Özlem Şimşek Kiper,Gülen Eda Utine,Mehmet Alikaşifoğlu,Koray Boduroğlu 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.2

Williams syndrome (OMIM #194050) is a rare, well-recognized, multisystemic genetic condition affecting approxi-mately 1/7,500 individuals. There are no marked regional differences in the incidence of Williams syndrome. The syndrome is caused by a hemizygous deletion of approximately 28 genes, including ELN on chromosome 7q11.2. Prenatal-onset growth retardation, distinct facial appearance, cardiovascular abnormalities, and unique hyperso-cial behavior are among the most common clinical features. Here, we report the case of a patient referred to us with distinct facial features and intellectual disability, who was diagnosed with Williams syndrome at the age of 37 years. Our aim is to increase awareness regarding the diagnostic features and complications of this recognizable syn-drome among adult health care providers. Williams syndrome is usually diagnosed during infancy or childhood, but in the absence of classical findings, such as cardiovascular anomalies, hypercalcemia, and cognitive impair-ment, the diagnosis could be delayed. Due to the multisystemic and progressive nature of the syndrome, accurate diagnosis is critical for appropriate care and screening for the associated morbidities that may affect the patient’s health and well-being.

Decreased Chitotriosidase Activity and Levels in Familial Mediterranean Fever

Halef Okan Doğan,Ahmet Omma,Turan Turhan,Nihal Boğdaycıoğlu,Yaşar Karaaslan,Hayrettin Yavuz,Özlem Demirpençe,Hüseyin Aydın,Sevtap Bakır 대한의학회 2016 Journal of Korean medical science Vol.31 No.12

Different studies have demonstrated changes in chitotriosidase (ChT) activity and concentrations in multiple diseases. However, changes in ChT activity and concentrations have not been concurrently evaluated in patients with Familial Mediterranean Fever (FMF). In this study, we analyzed the changes in serum ChT activity and concentrations in patients with FMF. The study included a total of 80 patients with FMF and 80 healthy controls. ChT enzyme activity and concentrations were measured and then compared between the groups. ChT activity was measured by using fluorometric ELISA and ChT concentrations were measured by using colorimetric ELISA methods. The median ChT activity was 10.00 (6.00–15.00) nmol/mL/hr in the patients and 14.00 (6.25–20.75) nmol/mL/hr in the controls. There was a statistically significant difference in the ChT activity between the controls and patients (P = 0.027). The median ChT concentrations were 65.40 (46.20–84.92) pg/mL and 125.00 (75.72–143.95) pg/mL in the patients and controls, respectively (P < 0.001), which were expressed as median percentiles (25th–75th). Additionally, we found no correlation between C-reactive protein and ChT activity (P = 0.978, r = 0.003) and concentrations (P = 0.446, r = −0.87). Serum ChT enzyme activity and concentrations may not be considered as a biomarker in FMF patients taking colchicine. New studies are needed to evaluate the changes of enzyme activity and concentration in colchicine-negative patients.