http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The acute and sub-acute toxicity of C<sub>60</sub>/PVP complex in vivo
Dumpis, Marina A.,Iljin, Viktor V.,Litasova, Elena V.,Nikolaev, Dmitry N.,Bulion, Valentina V.,Krylova, Irina B.,Okunevich, Irina V.,Rodionova, Olga M.,Safonova, Albina F.,Selina, Elena N.,Piotrovsky, Techno-Press 2016 Advances in nano research Vol.4 No.3
The detailed study of acute and sub-acute toxicity of the complex polyvinylpyrrolidon (PVP 20 kDa)-wrapped fullerene $C_{60}$ after intraperitoneal (ip) administration was carried out on adult male Wistar rats. The $LD_{50}$ value of $C_{60}/PVP$ complex was found to be 7, 8 g/kg. In sub-acute study which lasted for 30 days the rats were exposed to daily administration of the complex in the doses of 350 or 700 mg/kg. All animals survived during the study and had no significant changes in clinical signs, organ weight, hematological and biochemical parameters of blood. The electrophysiological properties of myocardium and the excretory function of kidneys remained normal. Histological analysis of liver, kidney and spleen at the end of the study also did not demonstrate toxic alterations. It was thus established that intraperitoneal administration of complex $C_{60}/PVP$ has no toxic effect. These results suggest that $C_{60}/PVP$ has no acute and sub-acute toxicity and is a perspective substance for potential application in biology and medicine.
A Novel Mathematical Model to Optimize Sustainable Supply Chain in the Lighting Products Industry
Gulmira Baybalinova,Andrey Goncharov,Igor Zavalishin,Igor Sokolov,Inna Trofimova,Denis Yashin,Alla Aleinova,Dmitry Piotrovsky,Rustem Zalilov 대한산업공학회 2021 Industrial Engineeering & Management Systems Vol.20 No.2
Nowadays, due to changing conditions in global markets and competition, the issue of sustainability is a priority for the work of world leaders and business managers and is of great importance. Many supply chain issues are affecting greenhouse gas emissions and supply chain sustainability, such as facility location design, transportation routes, inventory policies, and so on. Lighting products due to the nature of consumption and its very high waste, is one of the most important products in terms of environment and society. In this research, an attempt has been made to design logistics optimization model at the strategic and tactical level in a sustainable supply chain for lighting products, taking into account the economic dimension. In this regard, a nonlinear mathematical model for a sustainable supply chain has been developed with the aim of reducing carbon emissions and reducing total costs. In order to optimize this mathematical model, genetic algorithm has been used. The results of this study show that the design of a sustainable supply chain network in the lighting products industry can significantly reduce the adverse environmental impact of this supply chain.