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- 저자 : Didier Martinez (검색결과 2 건)
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Meulendijks, Didier,Jacob, Wolfgang,Voest, Emile E.,Mau-Sorensen, Morten,Martinez-Garcia, Maria,Taus, Alvaro,Fleitas, Tania,Cervantes, Andres,Lolkema, Martijn P.,Langenberg, Marlies H.G.,De Jonge, Maj American Association for Cancer Research 2017 Clinical Cancer research Vol.23 No.18
<P><B>Purpose:</B> This study investigated the safety, clinical activity, and target-associated biomarkers of lumretuzumab, a humanized, glycoengineered, anti-HER3 monoclonal antibody (mAb), in combination with the EGFR-blocking agents erlotinib or cetuximab in patients with advanced HER3-positive carcinomas.</P><P><B>Experimental Design:</B> The study included two parts: dose escalation and dose extension phases with lumretuzumab in combination with either cetuximab or erlotinib, respectively. In both parts, patients received lumretuzumab doses from 400 to 2,000 mg plus cetuximab or erlotinib according to standard posology, respectively. The effect of <I>HRG</I> mRNA and <I>HER3</I> mRNA and protein expression were investigated in a dedicated extension cohort of squamous non–small cell lung cancer (sqNSCLC) patients treated with lumretuzumab and erlotinib.</P><P><B>Results:</B> Altogether, 120 patients were treated. One dose-limiting toxicity (DLT) in the cetuximab part and two DLTs in the erlotinib part were reported. The most frequent adverse events were gastrointestinal and skin toxicities, which were manageable. The objective response rate (ORR) was 6.1% in the cetuximab part and 4.2% in the erlotinib part. In the sqNSCLC extension cohort of the erlotinib part, higher tumor <I>HRG</I> and <I>HER3</I> mRNA levels were associated with a numerically higher disease control rate but not ORR.</P><P><B>Conclusions:</B> The toxicity profile of lumretuzumab in combination with cetuximab and erlotinib was manageable, but only modest clinical activity was observed across tumor types. In the sqNSCLC cohort, there was no evidence of meaningful clinical benefit despite enriching for tumors with higher <I>HRG</I> mRNA expression levels. <I>Clin Cancer Res; 23(18); 5406–15. ©2017 AACR</I>.</P>
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A Comprehensive Comparison of Chassis Systems Coordination Approaches
Moad Kissai,Bruno Monsuez,Didier Martinez,Xavier Mouton,Adriana Tapus 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
One of the main concerns of automotive industry is autonomous vehicles. Not only equipment suppliers but also new entering actors are racing to develop safer automotive systems. Consequently, the car manufacturer has to integrate different systems to control the same vehicle. This paper discusses the different architectures adopted to handle chassis systems interactions. Several car manufacturers study the influence of each system on the overall vehicle. They then add an additional coordination layer downstream the different systems to mitigate their possible conflicts. Here we propose a new approach that consists on managing systems interaction upstream the different systems. Coordination is based on control allocation techniques that take into account several vehicle states to find optimal commands distribution. Both approaches have been compared. Simulations showed the benefits that could offer the upstream approach in terms of safety and flexibility. The relevance of this approach is expected to grow with the increasing number of chassis systems.
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