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      • SCOPUSKCI등재

        Sequential adsorption - photocatalytic oxidation process for wastewater treatment using a composite material TiO₂/activated carbon

        Caroline Andriantsiferana,Elham Farouk Mohamed,Henri Delmas 대한환경공학회 2015 Environmental Engineering Research Vol.20 No.2

        A composite material was tested to eliminate phenol in aqueous solution combining adsorption on activated carbon and photocatalysis with TiO₂ in two different ways. A first implementation involved a sequential process with a loop reactor. The aim was to reuse this material as adsorbent several times with in situ photocatalytic regeneration. This process alternated a step of adsorption in the dark and a step of photocatalytic oxidation under UV irradiation with or without H₂O₂. Without H₂O₂, the composite material was poorly regenerated due to the accumulation of phenol and intermediates in the solution and on TiO₂ particles. In presence of H₂O₂, the regeneration of the composite material was clearly enhanced. After five consecutive adsorption runs, the amount of eliminated phenol was twice the maximum adsorption capacity. The phenol degradation could be described by a pseudo first-order kinetic model where constants were much higher with H₂O₂ (about tenfold) due to additional .H radicals. The second implementation was in a continuous process as with a fixed bed reactor where adsorption and photocatalysis occurred simultaneously. The results were promising as a steady state was reached indicating stabilized behavior for both adsorption and photocatalysis.

      • SCISCIESCOPUS

        Evaluation of transdermal delivery of nanoemulsions in<i>ex vivo</i>porcine skin using two-photon microscopy and confocal laser-scanning microscopy

        Choi, Sanghoon,Kim, Jin Woong,Lee, Yong Joong,Delmas, Thomas,Kim, Changhwan,Park, Soyeun,Lee, Ho SPIE - International Society for Optical Engineeri 2014 JOURNAL OF BIOMEDICAL OPTICS Vol.19 No.10

        <P>This study experimentally evaluates the self-targeting ability of asiaticoside-loaded nanoemulsions compared with nontargeted nanoemulsions in ex vivo experiments with porcine skin samples. Homebuilt two-photon and confocal laser-scanning microscopes were employed to noninvasively examine the transdermal delivery of two distinct nanoemulsions. Prior to the application of nanoemulsions, we noninvasively observed the morphology of porcine skin using two-photon microscopy. We have successfully visualized the distributions of the targeted and nontargeted nanoemulsions absorbed into the porcine skin samples. Asiaticoside-loaded nanoemulsions showed an improved ex vivo transdermal delivery through the stratum corneum compared with nonloaded nanoemulsions. As a secondary measure, nanoemulsions-applied samples were sliced in the depth direction with a surgical knife in order to obtain the complete depth-direction distribution profile of Nile red fluorescence. XZ images demonstrated that asiaticoside-loaded nanoemulsion penetrated deeper into the skin compared with nontargeted nanoemulsions. The basal layer boundary is clearly visible in the case of the asiaticoside-loaded skin sample. These results reaffirm the feasibility of using self-targeting ligands to improve permeation through the skin barrier for cosmetics and topical drug applications.</P>

      • Qualitative comparison of chemical and green synthesized Fe<sub>3</sub>O<sub>4</sub> nanoparticles

        Gokila, V.,Perarasu, V.T.,Rufina, R. Delma Jones Techno-Press 2021 Advances in nano research Vol.10 No.1

        Synthesis of nanoparticles using green technology using plants is gaining significant attention as it is an environmentally friendly substitute to conventional physical and chemical methods. The present study was focused on the chemical and green synthesis of Iron Oxide nanoparticles from ferric chloride. The green synthesis was achieved by utilizing the bio components of Hibiscus rosa-sinensis. The Fe3O4 nanoparticles with the size range of 87-400 nm were synthesized by wet chemical reduction technique which are unstable, prone to aggregation while in green synthesis the phytochemicals present in the leaf extract acts as the capping as well as the reducing agent thus the green synthesized iron (III) oxide nanoparticles were naturally stabilized, spherical shaped and are in the size range of 2-80 nm. The results of both the protocols are compared and presented briefly.

      • KCI등재

        Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis

        Achua Justin K.,Chu Kevin Y.,Ibrahim Emad,Khodamoradi Kajal,Delma Katiana S.,Iakymenko Oleksii A.,Kryvenko Oleksandr N.,Arora Himanshu,Ramasamy Ranjith 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.1

        Purpose: To evaluate the presence and analyze the pathological changes within the testes of patients who died or recovered from severe acute respiratory syndrome coronavirus 2 (COVID-19) complications. Materials and Methods: Testis tissue was collected from autopsies of COVID-19 positive (n=6) and negative men (n=3). Formalin-fixed paraffin-embedded tissues were stained with hematoxylin and eosin (H&E) and subjected to immunofluorescence for angiotensin-converting enzyme 2 (ACE-2) expression. Fluorescent-labeled tissue slides were imaged on a quantitative pathology scope with various zoom levels allowing for qualitative and quantitative interpretation. Tissue from four COVID- 19 positive autopsy cases and a live seroconverted patient was imaged with transmission electron microscopy (TEM). Results: H&E histomorphology showed three of the six COVID-19 biopsies had normal spermatogenesis while the remaining three had impaired spermatogenesis. TEM showed the COVID-19 virus in testis tissue of one COVID-19 positive autopsy case and the live biopsy, H&E stain on the same autopsy case demonstrated interstitial macrophage and leukocyte infiltration. Immunofluorescent stained slides from six COVID-19 positive men demonstrated a direct association between increased quantitative ACE-2 levels and impairment of spermatogenesis. Conclusions: The novel COVID-19 has an affinity for ACE-2 receptors. Since ACE-2 receptor expression is high in the testes, we hypothesized that COVID-19 is prevalent in testes tissue of infected patients. This study suggests the male reproductive tract, specifically the testes, may be targets of COVID-19 infection. We found an inverse association between ACE-2 receptor levels and spermatogenesis, suggesting a possible mechanism of how COVID-19 can cause infertility.

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