http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Solubility modulation of bicalutamide using porous silica
Tarique Meer,Ritesh Fule,Deepak Khanna,Purnima Amin 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.4
Objective of the present study was to explore the potential of porous silica (AEROPERL 300 Pharma)in modulating dissolution kinetics of poorly water soluble drug bicalutamide (BCL). The drug release from the developed formulation was found to be significantly higher as compared to neat BCL. This improved release kinetics of BCL may be attributed to high surface area, improved wettability and decreased crystallinity. Solid state characterization of the developed formulation was carried out with respect to IR, XRPD, SEM, DSC and dissolution. The proposed system showed a significant capability for the solubility enhancement of BCL. The dissolution profile from BCL-AEROPERL 300 Pharma (AP) system was fitted into various drug release kinetics models, in order to understand the BCL release mechanism.