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이권용(Kwon-Yong Lee),박상국(Sang-Guk Park),Deahwan Shin,박종철(Jong-Chul Park) 한국트라이볼로지학회 2005 한국윤활학회지(윤활학회지) Vol.21 No.5
In order to prepare for the suitable surfaces of implants or medical devices, quantitative evaluation of adhesion between cells and biomaterials is essential. To better understand adhesion formation between cells and biomaterials, we used the cytodetachment technique which measures the adhesive force of a single cell through changing the culture time and detachment speed. The results showed that the adhesive force could be affected by the culture time of cells on the surface of materials and the detachment speed. Moreover, there was a large discrepancy among the adhesion strength measured by similar techniques conducted on the different cells and substrates. It can be concluded that the variation of the force measurement technique can seriously alter the level of the force required to detach a cell on the surface of materials.
이권용(K. Y. Lee),박상국(S. K. Park),Deahwan Shin,박종철(J. C. Park) 한국트라이볼로지학회 2004 한국트라이볼로지학회 학술대회 Vol.39 No.-
Quantitative evaluation of substrates for cells is essential to understanding cell-material adhesive interaction and it is also necessary for the development of new biomaterials. Many cells on adhesive molecules will form an organization of actin into bundles and production of the large, highly organized structures termed focal adhesions. To better understand adhesion formations between cells and substrata, we have quantified the force required to displace attached cell. we allowed rabbit knee chondrocyte to attach on a substratum of microscope slide glass. Our results demonstrate that a force is required to detach cells is changed according to detachment time variation.