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RISS 인기검색어
- 검색키워드
- 저자 : Dawsey, Anna C (검색결과 3 건)
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Dawsey, Anna C University of Southern California 2013 해외박사(DDOD)
Research laid out in this work describes the development of chemical mechanistic insight and synthesis of molecular building blocks in medicinal and diagnostic fields. The aerobic oxidation of azolines to azoles is of utmost significance in medicinal chemistry. The azole core is a ubiquitous structural component in biologically active natural products. Therefore, the necessity to efficiently and inexpensively synthesize these azole targets is of interest to chemists and clinicians alike. This work describes a copper-catalyzed aerobic oxidation of azolines to azoles that is high yielding and cost efficient. Along with copper-catalyzed conditions, a second set of copper-free, stoichiometric base-mediated conditions were developed for the entire substrate scope of the azoline to azole transformation. Both catalytic and stoichiometric base-mediated conditions demonstrate good yields with a substrate scope of thiazolines with aryl substituents in the 2-position with a range of electron withdrawing and electron donating groups. Catalytic conditions proved necessary for the transformation in the presence of labile protons such as the N-H proton of indole. The oxidation of azolines to azoles with both conditions were scaled to 1 g without a significant change in yield. Additionally, this work describes the development and characterization of the first ultrasound activated MRI contrast agent. The premise of an activatable MRI contrast agent can be applied to many different therapeutic and diagnostics systems. A two-component system has been developed in which contrast from a MRI contrast agent, Gd--DOTA, is masked by a proprietary shell formulated to be water impenetrable yet water-soluble. The hydrogen bonding interaction holding the shell to the contrast agent prevents water exchange with the paramagnetic gadolinium core, thus attenuating contrast. At the desired time and location, the contrast agent-shell interaction can be selectively disrupted externally with sonication to reveal the contrast.
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Dawsey, Jason The University of Chicago 2013 해외박사(DDOD)
My dissertation considers the development of trans-Atlantic debates in the three decades after 1945 concerning the effects of technological advancement. I am particularly interested in a powerful current in postwar thought: the confrontation with "autonomous technology," to borrow Langdon Winner's term. A veritable technological "turn" occurred in European and North American social and political theory in the quarter century after the end of the Second World War. This dissertation focuses on who I regard as the most prescient exemplar of this "turn," the German-Jewish intellectual and anti-nuclear militant Günther Anders (1902-1992). Still relatively unknown in Anglophone culture, Anders' books and essays addressed some of the most vital issues that confront the modern world, especially the lasting effects of technology on the human condition. He presaged, to some extent, and participated, for several decades, in this broader current of technology critique. In this study, I accent three endeavors interrelated in Anders' writings after 1945: his later philosophical anthropology, his bold revision of the precepts of Marxian thought, and his goal of forging a "concrete philosophy" of technological domination. I argue that Anders understood his fundamental systemic critique of technology to be a necessary, urgent, and critical revision of Marx's critique of industrial production, one suited to a social formation defined by the Fordist-Taylorist labor regime, the Keynesian welfare state, and huge defense industries. Anders' reflections on technology as "destiny" and as the new "Subject of History" attempted to critically overcome the historical limitations of much orthodox Marxist thought, with its focus on ownership of the means of production and class struggle. This work on Anders should contribute to attempts to think historically about forms of social critique that take technology as their object.
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The uses of sidewalks: Women, art, and urban space, 1966--1980
Dawsey, Jill Christina Stanford University 2008 해외박사(DDOD)
This dissertation examines women artists' interventions into urban space during the international rise of feminist and new social movements in the 1960s and 70s. I focus on the artistic practices of Yayoi Kusama, Valie Export, and Martha Rosler as three representative case studies that I take to be crucial examples of a larger development within feminist art of that period. Specifically, this development concerns the emergence of an explicitly spatialized form of feminist art production: sculptural, photographic, conceptual and performance practices that pointedly engaged the spatial parameters of the city. In a field of artistic practice that was itself preoccupied with questions of the spatial (from minimalism and installation to earth art and so on) many women artists began to imagine their own feminist responses to space---to imagine the production of new kinds of spaces. These responses would stem from their own positioning as "different," to advocate for a broad embrace of difference as the necessary condition of a working public (or counterpublic) sphere. The work of artists such as Kusama, Export, and Rosier, I argue, insisted upon the importance of difference within an urban setting that in the late 1960s and early 70s was registered as increasingly homogenous, increasingly colonized and saturated by capital---what Guy Debord would call "the spectacle." For these artists two concerns seem to emerge simultaneously: on the one hand, the fact that the cities they lived in were under pressure, were becoming increasingly contested spaces; and second, that as women, they might for the first time seize that space as their own, as a site of artistic production. The spatializing impulse in the work of Japanese artist Yayoi Kusama is the focus of the first chapter, in which I examine her movement from paintings and sculptural environments to her widely publicized "naked happenings." Next I turn to the street actions and "body configurations" of Austrian artist Valie Export, in which the stubborn particularities of the body are positioned against the rationalizing logic of the civic architectural system. Finally, I address Martha Rosler's urban-based work of the 1970s, exploring the ways in which her photographic and video practices operate around the terms of visibility and invisibility within the imbricated spheres of private and public life.
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