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RISS 인기검색어
- 검색키워드
- 저자 : Daris Theerakulpisut (검색결과 3 건)
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Value of SPECT/CT in Diagnostic I-131 MIBG Scintigraphy in Patients with Neuroblastoma
Daris Theerakulpisut,Yutapong Raruenrom,Nantaporn Wongsurawat,Charoonsak Somboonporn 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.5
Purpose Diagnostic I-131 MIBG scintigraphy is an important imaging modality for evaluation of patients with neuroblastoma(NB) especially in centers where I-123 MIBG is not available. Single photon emission computed tomography/computed tomography(SPECT/CT) could potentially improve lesion detection over planar scintigraphy, but studies regarding its usefulness as anadd-on to diagnostic I-131 MIBG scintigraphy are limited. This study aimed to determine the usefulness and factors related tousefulness of SPECT/CT in diagnostic I-131 MIBG scintigraphy in NB patients. Methods Usefulness of SPECT/CT for lesion detection, lesion localization, resolving suspicious findings, and clarifying thenature of lesions on anatomical imaging were retrospectively reviewed in 86 diagnostic planar I-131 MIBG scintigrams with addonSPECT/CT. Results SPECT/CT detected additional lesions in 23.2%(20/86), helped localize lesions in 21.1%(8/38), resolved suspiciousfindings in 85.7%(6/7), determined functional status of lesions on anatomical imaging in 94.4%(17/18), and changed diagnosisfrom a negative to a positive study in 19.5%(8/41). Independent predictors of SPECT/CT being useful included presence ofsuspicious findings on planar imaging (OR 99.08; 95% C.I. 6.99–1404.41; p = 0.001), positive findings on planar imaging (OR4.61; 95% C.I. 1.05, 20.28; p < 0.001), and presence of structural lesions on anatomical imaging (OR 32.54; 95% C.I. 5.37–196.96; p < 0.001). Conclusion SPECT/CT is a useful add-on to diagnostic planar I-131 MIBG scintigraphy. Predictors of usefulness of SPECT/CTinclude suspicious or positive findings on planar scintigraphy and the presence of structural lesions on anatomical imaging.
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Daris Theerakulpisut,Bandit Thinkhamrop,Sirirat Anutrakulchai 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.6
Purpose Renal scintigraphy (RS) with either technetium-99 m diethylene-triamine-pentaacetate (Tc-99 m DTPA) or technetium-99 m mercaptoacetyltriglycine (Tc-99 m MAG3) has both been used to evaluate early allograft function after kidneytransplantation (KT). This study was done to compare the predictive performance of RS using these two radiopharmaceuticalsfor prediction of outcomes during first 3 months of KT. Methods This retrospective study included patients who received KT then underwent both Tc-99 m DTPA and Tc-99 mMAG3 RS, successively. Receiver operating characteristic (ROC) curve analysis was used to determine the predictivenessof RS parameters on early clinical adverse outcomes of either (1) graft-related death, (2) need for graft resection, (3) delayedgraft function requiring temporary dialysis, or (4) a serum creatinine level of≥2.0 mg/dL at three months post-KT, as wellas to predict biopsy-confirmed acute tubular necrosis and acute rejection. Results Of 187 patients included, 77 (41.2%) had at least one early adverse clinical outcome. Tc-99 m MAG3 RS was morepredictive than Tc-99 m DTPA RS, in terms of AUCROC, in three parameters including time to peak (0.754 vs. 0.516, p-value0.0001), 20-min to peak ratio (0.762 vs. 0.651, p-value 0.006), and 20-min to 3-min ratio (0.823 vs. 0.699, p-value 0.0005). Acute tubular necrosis was better predicted by Tc-99 m MAG3 RS while both were at best only modest in predicting acuterejection. Conclusion Three parameters which, when obtained from Tc-99 m MAG3 RS, had superior predictiveness compared withTc-99 m DTPA RS, including time to peak, 20-min to peak ratio, and 20-min to 3-min ratio.
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Theerakulpisut, Daris,Wongsurawat, Nantaporn,Supakalin, Narudom,Somboonporn, Charoonsak 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.1
Purpose The value of bone scintigraphy (BS) in patients with head and neck cancers (HNCs) has been questioned, with conflicting findings regarding positivity yield with some reports recommending BS be omitted from work-up of HNC patients since it rarely yields positive results. This study aims to determine the positivity yield of BS in HNCs and to determine predictors for BS positivity to help tailor appropriate BS utilization. Methods BS studies of HNC patients were reviewed, the positivity yield was determined. Clinical predictors for BS positivity including age, sex, site of cancer, staging, histological grading were analyzed using univariable and multivariable logistic regression. Results Among the 259 BS studies included, 35 (13.5%), 194 (74.9%), and 30 (11.6%) were positive, negative, and equivocal for bone metastasis, respectively. After exclusion of equivocal cases, 229 were analyzed in the regression models. Independent predictors of BS positivity include site of tumor at the nasopharynx (OR 4.37, 95% C.I. 1.04-18.41, p = 0.044), age less than 45 years (OR 3.01, 95% C.I. 1.24-7.33, p = 0.015), and presence of distant metastasis to other organs (OR 3.84, 95% C.I. 1.19-12.43, p = 0.025). Conclusions In contrast to several studies, bone metastasis as detected by BS was found in a relatively high proportion of patients with HNCs. Independent predictors of BS positivity include the age of less than 45 years, tumor site at the nasopharynx, and the presence of extraskeletal distant metastasis. BS could be useful in patients with these characteristics which enhance the pretest probability of bone metastasis.
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