http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults
Alvarez-Fischer, Daniel,Fuchs, Julia,Castagner, Fran챌ois,Stettler, Olivier,Massiani-Beaudoin, Olivia,Moya, Kenneth L,Bouillot, Colette,Oertel, Wolfgang H,Lomb챔s, Anne,Faigle, Wolfgang,Joshi, Rajiv L,H Nature Publishing Group, a division of Macmillan P 2011 NATURE NEUROSCIENCE Vol.14 No.10
Mice heterozygous for the homeobox gene Engrailed-1 (En1) display progressive loss of mesencephalic dopaminergic (mDA) neurons. We report that exogenous Engrailed-1 and Engrailed-2 (collectively Engrailed) protect mDA neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a mitochondrial complex I toxin used to model Parkinson's disease in animals. Engrailed enhances the translation of nuclearly encoded mRNAs for two key complex I subunits, Ndufs1 and Ndufs3, and increases complex I activity. Accordingly, in vivo protection against MPTP by Engrailed is antagonized by Ndufs1 small interfering RNA. An association between Engrailed and complex I is further confirmed by the reduced expression of Ndufs1 and Ndufs3 in the substantia nigra pars compacta of En1 heterozygous mice. Engrailed also confers in vivo protection against 6-hydroxydopamine and 慣-synuclein-A30P. Finally, the unilateral infusion of Engrailed into the midbrain increases striatal dopamine content, resulting in contralateral amphetamine-induced turning. Therefore, Engrailed is both a survival factor for adult mDA neurons and a regulator of their physiological activity.
Robust Synchronization of Arrays of Lagrangian Systems
David Rosas,Joaquin Alvarez,Daniel Hernandez,Ervin Alvarez 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.5
A new technique to synchronize arrays of uncertain, disturbed Lagrangian systems, where the synchro-nization signals use only the position measurement, is proposed. The technique, robust with respect to some kinds of connection losses and matched disturbances, can be applied to different topologies whose connection matrix is not necessarily symmetric. The design of the coupling signals is based on a discontinuous robust observer that identifies, at the same time, the velocity vector and any matched disturbance containing unknown terms, parameter uncertainty, or unknown external perturbations. This estimated disturbance is incorporated in the coupling signal to compensate the real perturbations, improving significantly the synchronization performance. The technique is illustrated with numerical simulations and some experiments carried on some real systems.
Extracorporeal Pedicles for Free Flap Reconstruction in Diabetic Lower Extremity Wounds
Alejandro R. Gimenez,Daniel Lazo,Salomao Chade,Alex Fioravanti,Olimpio Colicchio,Daniel Alvarez,Ernani Junior,Sarth Raj,Amjed Abu-Ghname,Marco Maricevich 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.6
Diabetic foot ulcers are a severe complication of diabetes, and their management requires a multidisciplinary approach for optimal management. When treating these ulcers, limb salvage remains the ultimate goal. In this article, we present the “hanging” free flap for the reconstruction of chronic lower extremity diabetic ulcers. This twostaged approach involves standard free flap harvest and inset; however, following inset the “hanging” pedicle is covered within a skin graft instead of making extraneous incisions within the undisturbed soft tissues or tunnels that can compress the vessels. After incorporation, a second-stage surgery is performed in 4 to 6 weeks which entails pedicle division, flap inset revision, and end-to-end reconstruction of the recipient vessel. Besides decreasing the number of incisions on diabetic patients, our novel technique utilizing the “hanging” pedicle simplifies flap monitoring and inset and allows reconstruction of recipient vessels to reestablish distal blood flow.
Syed Faraz Kazim,Alis J. Dicpinigaitis,Christian A. Bowers,Smit Shah,William T. Couldwell,Rachel Thommen,Daniel J. Alvarez-Crespo,Matthew Conlon,Omar H. Tarawneh,John Vellek,Kyril L. Cole,Jose F. Domi 대한척추신경외과학회 2022 Neurospine Vol.19 No.1
Objective: The present study aimed to evaluate the effect of baseline frailty status (as measured by modified frailty index-5 [mFI-5]) versus age on postoperative outcomes of patients undergoing surgery for spinal tumors using data from a large national registry. Methods: The National Surgical Quality Improvement Program database was used to collect spinal tumor resection patients’ data from 2015 to 2019 (n = 4,662). Univariate and multivariate analyses for age and mFI-5 were performed for the following outcomes: 30-day mortality, major complications, unplanned reoperation, unplanned readmission, hospital length of stay (LOS), and discharge to a nonhome destination. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminative performance of age versus mFI-5. Results: Both univariate and multivariate analyses demonstrated that mFI-5 was a more robust predictor of worse postoperative outcomes as compared to age. Furthermore, based on categorical analysis of frailty tiers, increasing frailty was significantly associated with increased risk of adverse outcomes. ‘Severely frail’ patients were found to have the highest risk, with odds ratio 16.4 (95% confidence interval [CI],11.21–35.44) for 30-day mortality, 3.02 (95% CI, 1.97–4.56) for major complications, and 2.94 (95% CI, 2.32–4.21) for LOS. In ROC curve analysis, mFI-5 score (area under the curve [AUC] = 0.743) achieved superior discrimination compared to age (AUC = 0.594) for mortality. Conclusion: Increasing frailty, as measured by mFI-5, is a more robust predictor as compared to age, for poor postoperative outcomes in spinal tumor surgery patients. The mFI-5 may be clinically used for preoperative risk stratification of spinal tumor patients.