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D. Lukic,A. Prokic,P. Anagnosti 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.35 No.4
The present paper will be concerned to the investigation of the stress-strain field around the cavity that is loaded or partially loaded at the inner surface by the rotationally symmetric loading. The cavity of the spherical, cylindrical or elliptical shape is situated in a stressed elastic continuum, subjected to the gravitation field. As the contribution to the similar investigations, the paper introduces the new function of loading in the form of the infinite sine series. Besides, in this paper the solution of stresses around an oblong ellipsoid cavity, has been obtained using appropriate curvilinear elliptical coordinates. This analytical approach avoids the solutions of the same problem that lead to expressions that contain rather complex integrations. Thus the presented solutions provide the applicable and explicit expressions for stresses and strains developed in infinite series with easily determinable coefficients by the use of contemporary mathematical packages. The numerical examples are also included to confirm the convergence of the obtained solutions.
Lukic, D.,Prokic, A.,Anagnosti, P. Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.35 No.4
The present paper will be concerned to the investigation of the stress-strain field around the cavity that is loaded or partially loaded at the inner surface by the rotationally symmetric loading. The cavity of the spherical, cylindrical or elliptical shape is situated in a stressed elastic continuum, subjected to the gravitation field. As the contribution to the similar investigations, the paper introduces the new function of loading in the form of the infinite sine series. Besides, in this paper the solution of stresses around an oblong ellipsoid cavity, has been obtained using appropriate curvilinear elliptical coordinates. This analytical approach avoids the solutions of the same problem that lead to expressions that contain rather complex integrations. Thus the presented solutions provide the applicable and explicit expressions for stresses and strains developed in infinite series with easily determinable coefficients by the use of contemporary mathematical packages. The numerical examples are also included to confirm the convergence of the obtained solutions.
Stress state around cylindrical cavities in transversally isotropic rock mass
Lukic, Dragan C.,Prokic, Aleksandar D.,Brcic, Stanko V. Techno-Press 2014 Geomechanics & engineering Vol.6 No.3
The present paper is dealing with the investigation of the stress field around the infinitely long cylindrical cavity, of a circular cross section, contained in the transversally isotropic elastic continuum. Investigation is based upon the determination of the stress function that satisfies the biharmonic equation, for the given boundary conditions and for rotationaly symmetric loading. The solution of the partial differential equation of the problem is given in the form of infinite series of Bessel's functions. Determination of the stress-strain field around cavities is a common requirement for estimation of safety of underground rock excavations.
Automatic analysis of thin-walled laminated composite sections
A. Prokic,D. Lukic,Dj. Ladjinovic 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.16 No.3
In this paper a computer program is developed for the determination of geometrical and material properties of composite thin-walled beams with arbitrary open cross-section and any arbitrary laminate stacking sequence. Theory of thin-walled composite beams is based on assumptions consistent with the Vlasov's beam theory and classical lamination theory. The program is written in Fortran 77. Some numerical examples are given, with complete information about input and output.
Winthrop, K L,Park, S-H,Gul, A,Cardiel, M H,Gomez-Reino, J J,Tanaka, Y,Kwok, K,Lukic, T,Mortensen, E,Ponce de Leon, D,Riese, R,Valdez, H BMJ Publishing Group 2016 Annals of the Rheumatic Diseases Vol.75 No.6
<P><B>Objectives</B></P><P>To evaluate the risk of opportunistic infections (OIs) in patients with rheumatoid arthritis (RA) treated with tofacitinib.</P><P><B>Methods</B></P><P>Phase II, III and long-term extension clinical trial data (April 2013 data-cut) from the tofacitinib RA programme were reviewed. OIs defined a priori included mycobacterial and fungal infections, multidermatomal herpes zoster and other viral infections associated with immunosuppression. For OIs, we calculated crude incidence rates (IRs; per 100 patient-years (95% CI)); for tuberculosis (TB) specifically, we calculated rates stratified by patient enrolment region according to background TB IR (per 100 patient-years): low (≤0.01), medium (>0.01 to ≤0.05) and high (>0.05).</P><P><B>Results</B></P><P>We identified 60 OIs among 5671 subjects; all occurred among tofacitinib-treated patients. TB (crude IR 0.21, 95% CI of (0.14 to 0.30)) was the most common OI (n=26); median time between drug start and diagnosis was 64 weeks (range 15–161 weeks). Twenty-one cases (81%) occurred in countries with high background TB IR, and the rate varied with regional background TB IR: low 0.02 (0.003 to 0.15), medium 0.08 (0.03 to 0.21) and high 0.75 (0.49 to 1.15). In Phase III studies, 263 patients diagnosed with latent TB infection were treated with isoniazid and tofacitinib concurrently; none developed TB. For OIs other than TB, 34 events were reported (crude IR 0.25 (95% CI 0.18 to 0.36)).</P><P><B>Conclusions</B></P><P>Within the global tofacitinib RA development programme, TB was the most common OI reported but was rare in regions of low and medium TB incidence. Patients who screen positive for latent TB can be treated with isoniazid during tofacitinib therapy.</P>